JPS59144765A - ２−（１−ピペラジニル）ピリミジン、その製造方法およびそれを含む医薬組成物 - Google Patents

２−（１−ピペラジニル）ピリミジン、その製造方法およびそれを含む医薬組成物

Info

Publication number
JPS59144765A
JPS59144765A JP58209262A JP20926283A JPS59144765A JP S59144765 A JPS59144765 A JP S59144765A JP 58209262 A JP58209262 A JP 58209262A JP 20926283 A JP20926283 A JP 20926283A JP S59144765 A JPS59144765 A JP S59144765A
Authority
JP
Japan
Prior art keywords
group
lower alkyl
hydrogen
atk
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58209262A
Other languages
English (en)
Japanese (ja)
Inventor
パオロ・カルミナチ
カトリ−ン・ビジエ−ル
アンドレ・ハロ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JPS59144765A publication Critical patent/JPS59144765A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58209262A 1982-11-09 1983-11-09 ２−（１−ピペラジニル）ピリミジン、その製造方法およびそれを含む医薬組成物 Pending JPS59144765A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8218819A FR2535718A1 (fr) 1982-11-09 1982-11-09 (piperazinyl-1)-2 pyrimidines, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant
FR8218819 1982-11-09

Publications (1)

Publication Number Publication Date
JPS59144765A true JPS59144765A (ja) 1984-08-18

Family

ID=9279047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58209262A Pending JPS59144765A (ja) 1982-11-09 1983-11-09 ２−（１−ピペラジニル）ピリミジン、その製造方法およびそれを含む医薬組成物

Country Status (7)

Country Link
US (1) US4542136A (OSRAM)
EP (1) EP0115713B1 (OSRAM)
JP (1) JPS59144765A (OSRAM)
AT (1) ATE28726T1 (OSRAM)
CA (1) CA1256248A (OSRAM)
DE (1) DE3372844D1 (OSRAM)
FR (1) FR2535718A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004928A1 (fr) * 1986-02-24 1987-08-27 Mitsui Petrochemical Industries, Ltd. Agents therapeutiques de la neuropathie
JP2561689B2 (ja) * 1986-02-24 1996-12-11 三井石油化学工業株式会社 神経疾患用治療薬

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
ES2125206B1 (es) 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748129A (en) * 1954-04-26 1956-05-29 American Cyanamid Co Sulfamylpiperazines and method of preparing the same
NL237878A (OSRAM) * 1958-04-07
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
FR2445M (fr) * 1962-02-26 1964-04-06 Soc Ind Fab Antibiotiques Sifa Nouveaux dérivés de la pipérazine, utilisables en thérapeutique.
GB1279843A (en) * 1969-05-23 1972-06-28 Science Union & Cie Benzamidoethyl-piperazines and process for their preparation
AT302332B (de) * 1970-11-03 1972-10-10 Sumitomo Chemical Co Verfahren zur Herstellung von Arylketonderivaten sowie von Säureadditionssalzen hievon
US4247549A (en) * 1978-12-27 1981-01-27 Ici Americas Inc. Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004928A1 (fr) * 1986-02-24 1987-08-27 Mitsui Petrochemical Industries, Ltd. Agents therapeutiques de la neuropathie
JP2561689B2 (ja) * 1986-02-24 1996-12-11 三井石油化学工業株式会社 神経疾患用治療薬

Also Published As

Publication number Publication date
CA1256248A (en) 1989-06-20
FR2535718B1 (OSRAM) 1985-05-17
EP0115713B1 (fr) 1987-08-05
DE3372844D1 (en) 1987-09-10
FR2535718A1 (fr) 1984-05-11
EP0115713A1 (fr) 1984-08-15
ATE28726T1 (de) 1987-08-15
US4542136A (en) 1985-09-17

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