JPS591428A - ヒト成長ホルモン変異体 - Google Patents

ヒト成長ホルモン変異体

Info

Publication number
JPS591428A
JPS591428A JP58047803A JP4780383A JPS591428A JP S591428 A JPS591428 A JP S591428A JP 58047803 A JP58047803 A JP 58047803A JP 4780383 A JP4780383 A JP 4780383A JP S591428 A JPS591428 A JP S591428A
Authority
JP
Japan
Prior art keywords
gene
dna
sequence
growth hormone
human growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58047803A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0434559B2 (enExample
Inventor
ペ−タ−・ハ−・ジ−ブルク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JPS591428A publication Critical patent/JPS591428A/ja
Publication of JPH0434559B2 publication Critical patent/JPH0434559B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP58047803A 1982-03-22 1983-03-22 ヒト成長ホルモン変異体 Granted JPS591428A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US360517 1982-03-22
US06/360,517 US4446235A (en) 1982-03-22 1982-03-22 Method for cloning human growth hormone varient genes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP3324324A Division JPH0775548B2 (ja) 1982-03-22 1991-12-09 ヒト成長ホルモン変異蛋白質をコードしているｄｎａ

Publications (2)

Publication Number Publication Date
JPS591428A true JPS591428A (ja) 1984-01-06
JPH0434559B2 JPH0434559B2 (enExample) 1992-06-08

Family

ID=23418312

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58047803A Granted JPS591428A (ja) 1982-03-22 1983-03-22 ヒト成長ホルモン変異体
JP3324324A Expired - Lifetime JPH0775548B2 (ja) 1982-03-22 1991-12-09 ヒト成長ホルモン変異蛋白質をコードしているｄｎａ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP3324324A Expired - Lifetime JPH0775548B2 (ja) 1982-03-22 1991-12-09 ヒト成長ホルモン変異蛋白質をコードしているｄｎａ

Country Status (4)

Country Link
US (1) US4446235A (enExample)
EP (1) EP0089666A3 (enExample)
JP (2) JPS591428A (enExample)
GB (1) GB2116980B (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW18282A1 (en) * 1981-08-31 1983-03-23 Genentech Inc Preparation of polypeptides in vertebrate cell culture
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
JPS5931799A (ja) * 1982-08-16 1984-02-20 Science & Tech Agency Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド
US4977092A (en) * 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
JPH0716432B2 (ja) * 1982-10-20 1995-03-01 サントリー株式会社 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
CA1341302C (en) * 1983-02-22 2001-10-09 Rae Lyn Burke Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein
DE3480006D1 (en) * 1983-05-19 1989-11-09 Unilever Nv Improvements in the expression of newly introduced genes in yeast cells
FR2552776B1 (fr) * 1983-10-03 1986-05-09 Transgene Sa Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin
WO1985001516A1 (fr) * 1983-10-03 1985-04-11 Transgene S.A. Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US5118627A (en) * 1984-02-27 1992-06-02 Amgen Papova virus construction
DE3588219T2 (de) 1984-03-01 2000-05-18 The Board Of Trustees Of The Leland S. Stanford Junior University, Stanford T-Zellenrezeptor, spezifisch für Antigenpolypeptide und verwandte Polynukleotide
US4767709A (en) * 1984-06-28 1988-08-30 The Johns Hopkins University Growth-related hormones
US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins
DE3688418T2 (de) * 1985-02-13 1993-08-26 Scios Nova Inc Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen.
US5631227A (en) * 1985-09-18 1997-05-20 The Upjohn Company Somatotropin analogs
FR2596414B1 (fr) * 1986-03-28 1989-10-06 Pasteur Institut Hybridomes obtenus a partir de lymphocytes d'animaux transgeniques portant un gene exprimant une proteine donnee et procede de preparation d'une telle proteine a partir de tels hybridomes
JPH01502640A (ja) * 1987-03-12 1989-09-14 アムジエン・インコーポレーテツド ウシ成長ホルモン類似体
US4784649A (en) * 1987-03-20 1988-11-15 The Cooper Companies, Inc. Surgical aspirator cannula
EP0342926B1 (en) * 1988-05-17 1994-09-28 Mycogen Plant Science, Inc. Plant ubiquitin promoter system
US5177011A (en) * 1988-08-18 1993-01-05 Calgene, Inc. Plant elongation factor promoters, coding sequences and uses
US5079345A (en) * 1988-08-19 1992-01-07 Eli Lilly And Company Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
JPH04500970A (ja) 1988-09-02 1992-02-20 ザ ロックフェラー ユニヴァーシティ マクロファージ由来炎症メディエーター　（ｍｉｐ―２）
US5534617A (en) * 1988-10-28 1996-07-09 Genentech, Inc. Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
US5688666A (en) * 1988-10-28 1997-11-18 Genentech, Inc. Growth hormone variants with altered binding properties
ATE189526T1 (de) * 1988-10-28 2000-02-15 Genentech Inc Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
JPH04502762A (ja) * 1989-01-19 1992-05-21 ジ・アップジョン・カンパニー ソマトトロピン・アナログ
US6965059B1 (en) * 1989-02-21 2005-11-15 Boyce Thompson Institute For Plant Research, Inc. Method of protecting plants by introducing a gene coded for a protein which enhances virus infection of host insects
KR927003633A (ko) * 1989-07-10 1992-12-18 로버트 에이. 아미테이지 소마토트로핀 유사체
US5663305A (en) * 1989-07-10 1997-09-02 The Upjohn Company Somatotropin analogs
US7037692B1 (en) * 1990-03-16 2006-05-02 Calgene, Inc. Plant desaturases compositions and uses
WO1991013972A1 (en) * 1990-03-16 1991-09-19 Calgene, Inc. Plant desaturases - compositions and uses
US6117677A (en) * 1990-03-16 2000-09-12 Thompson; Gregory A. Plant stearoyl-ACP desaturases genes
JPH06500559A (ja) * 1990-08-17 1994-01-20 ジェネンテク，インコーポレイテッド 金属イオン媒介のポリペプチドホルモンのレセプター結合
CA2095633C (en) * 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
IL100908A0 (en) * 1991-02-22 1992-11-15 Salk Inst Biotech Ind Invertase genes and their use
US5744139A (en) * 1991-06-28 1998-04-28 University Of Tennessee Research Corporation Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios
US5202119A (en) * 1991-06-28 1993-04-13 Genentech, Inc. Method of stimulating immune response
US5317012A (en) * 1991-10-04 1994-05-31 The University Of Tennessee Research Corporation Human growth hormone induced improvement in depressed T4/T8 ratio
DE69435280D1 (de) 1993-03-10 2010-04-15 Glaxosmithkline Llc Phosphodiesterase des menschlichen Gehirns und Screening-Verfahren
US5597709A (en) 1994-01-27 1997-01-28 Human Genome Sciences, Inc. Human growth hormone splice variants hGHV-2(88) and hGHV-3(53)
EP0851925B1 (en) * 1995-09-21 2005-08-03 Genentech, Inc. Human growth hormone variants
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
EP1740608B1 (en) 2004-02-02 2012-02-22 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
DE602004031982D1 (de) * 2004-06-23 2011-05-05 Usv Ltd Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
US7998930B2 (en) * 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
JP2008525032A (ja) 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド 組換えヒト成長ホルモンを発現及び精製するための方法
NZ584597A (en) * 2004-12-22 2011-09-30 Ambrx Inc Modified human growth hormone
CA2594561C (en) * 2004-12-22 2014-12-23 Ambrx, Inc. Formulations of human growth hormone comprising a non-naturally encoded amino acid
WO2009157926A1 (en) * 2008-06-25 2009-12-30 Braasch Biotech Llc Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof
CN102119033B (zh) * 2008-06-25 2015-04-08 布拉施生物技术有限责任公司 用于增强促生长素抑制素免疫原性的组合物和方法
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients
WO2013059507A1 (en) 2011-10-20 2013-04-25 University Of Iowa Research Foundation N-demethyase genes and uses thereof
EP2861740A1 (en) 2012-06-15 2015-04-22 University of Iowa Research Foundation Caffeine responsive promoters and regulatory genes
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
JP6664011B2 (ja) 2016-10-24 2020-03-13 オンテラ インコーポレイテッド サンプル中のポリヌクレオチド配列のための存在量パラメータの決定
JP2025524901A (ja) 2022-07-29 2025-08-01 ユニバーシティ オブ ロチェスター テストステロン及び成長ホルモンの組み合わせによる筋量、筋強度、又は筋機能を改善するための方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
GR68404B (enExample) * 1979-06-01 1981-12-29 Univ California
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
ZA811895B (en) * 1980-04-07 1982-04-28 Univ California Expression of hormone genomic clones
US4343764A (en) * 1980-04-28 1982-08-10 The United States Of America As Represented By The United States Department Of Energy Nuclear reactor control column

Also Published As

Publication number Publication date
JPH05199880A (ja) 1993-08-10
EP0089666A3 (en) 1986-03-19
US4446235A (en) 1984-05-01
GB8307707D0 (en) 1983-04-27
JPH0775548B2 (ja) 1995-08-16
EP0089666A2 (en) 1983-09-28
JPH0434559B2 (enExample) 1992-06-08
GB2116980B (en) 1985-07-10
GB2116980A (en) 1983-10-05

Similar Documents

Publication Publication Date Title
JPS591428A (ja) ヒト成長ホルモン変異体
US4670393A (en) DNA vectors encoding a novel human growth hormone-variant protein
Thiele et al. Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene
Hickey et al. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein
Moye-Rowley et al. Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
US4833080A (en) Regulation of eucaryotic gene expression
Lehrach et al. Construction and characterization of a 2.5-kilobase procollagen clone.
Miyamoto et al. Stimulation of in vitro transcription by the upstream element of the adenovirus-2 major late promoter involves a specific factor
JPH022339A (ja) 先端を切断したα―因子リーダー配列を用いた酵母における異種タンパクの改良された発現および分泌
GB2137208A (en) The use of the gal1 promoter
Molenaar et al. Structure and organization of two linked ribosomal protein genes in yeast
Morishima et al. A subunit of yeast site-specific endonuclease SceI is a mitochondrial version of the 70-kDa heat shock protein.
JPH02104291A (ja) 酵母におけるタンパクの高レベル発現
EP0037723A2 (en) Expression of hormone genomic clones
Filho et al. Stable Yeast Transformants that Secrete Functional α–Amylase Encoded by Cloned Mouse Pancreatic cDNA
EP0111389A2 (en) Substantially pure porcine growth hormone, DNA sequences therefor, and expression vehicles and transfected microorganisms for the production of porcine growth hormone
JPH0759193B2 (ja) 外来性蛋白質発現用クロ−ニングベクタ−
EP0724639B1 (en) Methods for selection of recombinant host cells expressing high levels of a desired protein
US4665160A (en) Novel human growth hormone like protein HGH-V encoded in the human genome
EP0118393A2 (en) Methods and compositions for expression of competent eukaryotic gene products
AU665034B2 (en) Production of human parathyroid hormone from microorganisms
Lagosky et al. Molecular characterization of the Saccharomyces cerevisiae dihydrofolate reductase gene (DFRl)
US20040005668A1 (en) Production of human parathyroid hormone from microorganisms
JPS63289A (ja) バクテリアにおける新規リボゾ−ム結合部位を用いたタンパク生産の増強
Yu et al. Some of the signals for 3′-end formation in transcription of the Saccharomyces cerevisiae Ty-D15 element are immediately downstream of the initiation site