JPS59137500A - メチルプレドニソロンのスルホン酸エステルプロドラツグ - Google Patents

メチルプレドニソロンのスルホン酸エステルプロドラツグ

Info

Publication number
JPS59137500A
JPS59137500A JP59009363A JP936384A JPS59137500A JP S59137500 A JPS59137500 A JP S59137500A JP 59009363 A JP59009363 A JP 59009363A JP 936384 A JP936384 A JP 936384A JP S59137500 A JPS59137500 A JP S59137500A
Authority
JP
Japan
Prior art keywords
formula
acid
ester
compound
corticosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59009363A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0226639B2 (https=
Inventor
ブラドレイ・デイル・アンダーソン
ロバート・アレン・コンラジ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of JPS59137500A publication Critical patent/JPS59137500A/ja
Publication of JPH0226639B2 publication Critical patent/JPH0226639B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59009363A 1983-01-21 1984-01-21 メチルプレドニソロンのスルホン酸エステルプロドラツグ Granted JPS59137500A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/459,742 US4472392A (en) 1983-01-21 1983-01-21 Sulfonate containing ester prodrugs of corticosteroids
US459742 1983-01-21

Publications (2)

Publication Number Publication Date
JPS59137500A true JPS59137500A (ja) 1984-08-07
JPH0226639B2 JPH0226639B2 (https=) 1990-06-12

Family

ID=23825979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59009363A Granted JPS59137500A (ja) 1983-01-21 1984-01-21 メチルプレドニソロンのスルホン酸エステルプロドラツグ

Country Status (8)

Country Link
US (1) US4472392A (https=)
EP (1) EP0120557B1 (https=)
JP (1) JPS59137500A (https=)
CA (1) CA1199908A (https=)
DE (1) DE3478605D1 (https=)
HK (1) HK43993A (https=)
MX (1) MX9203197A (https=)
ZA (1) ZA838826B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010514674A (ja) * 2006-10-12 2010-05-06 ベラス ヘルス （インターナショナル） リミテッド ３−アミノ−１−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US5446177A (en) * 1984-12-28 1995-08-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
JP2549724B2 (ja) * 1987-07-16 1996-10-30 ジ・アップジョン・カンパニー アルカンー１，ｎージカルボン酸モノー（２ースルファトエチル）アミド類のアミン塩類
CA2152374A1 (en) * 1993-01-08 1994-07-21 Ralph Lennart Brattsand Novel colon- or ileum-specific steroid derivatives
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
US20040157810A1 (en) * 2002-08-23 2004-08-12 Teicher Martin H. Corticosteroid conjugates and uses thereof
JP2007504123A (ja) * 2003-08-29 2007-03-01 ランバクシー ラボラトリーズ リミテッド Ｉｖ型ホスホジエステラーゼの阻害剤
EP1694655A2 (en) * 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
WO2007045980A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
EA200900472A1 (ru) * 2006-09-22 2009-10-30 Ранбакси Лабораторис Лимитед Ингибиторы фосфодиэстеразы iv типа
US20100029728A1 (en) * 2006-09-22 2010-02-04 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
DK2124944T3 (da) 2007-03-14 2012-04-23 Ranbaxy Lab Ltd Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer
EP2249921B1 (en) 2008-02-25 2020-06-17 Eyegate Pharmaceuticals, Inc. Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
CN116514829A (zh) * 2020-08-21 2023-08-01 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3171846A (en) * 1962-07-10 1965-03-02 Erba Carlo Spa Prednisolone-21-double esters
NL124139C (https=) * 1964-11-04
FR6590M (https=) * 1967-10-31 1968-12-30
US3609712A (en) * 1969-01-15 1971-09-28 Ibm Insulated gate field effect transistor memory array
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
DK404879A (da) * 1978-10-04 1980-04-05 Schering Ag Kortikoid-21-sulfopropionater og deres salte fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse forbindelser
DE2848423A1 (de) * 1978-11-08 1980-05-29 Merck Patent Gmbh Hydrocortisonester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010514674A (ja) * 2006-10-12 2010-05-06 ベラス ヘルス （インターナショナル） リミテッド ３−アミノ−１−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体
US8748656B2 (en) 2006-10-12 2014-06-10 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
JP2015007047A (ja) * 2006-10-12 2015-01-15 ビーエイチアイ リミテッド パートナーシップ ３−アミノ−１−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体
US10238611B2 (en) 2006-10-12 2019-03-26 Bellus Health Inc. Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US10857109B2 (en) 2006-10-12 2020-12-08 Bellus Health, Inc. Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US11020360B2 (en) 2006-10-12 2021-06-01 Bellus Health Inc. Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

Also Published As

Publication number Publication date
MX9203197A (es) 1992-09-01
EP0120557A2 (en) 1984-10-03
JPH0226639B2 (https=) 1990-06-12
US4472392A (en) 1984-09-18
CA1199908A (en) 1986-01-28
HK43993A (en) 1993-05-14
DE3478605D1 (en) 1989-07-13
EP0120557B1 (en) 1989-06-07
ZA838826B (en) 1984-07-25
EP0120557A3 (en) 1985-02-06

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