JPS59128329A - 抗ウィルス剤 - Google Patents
抗ウィルス剤Info
- Publication number
- JPS59128329A JPS59128329A JP58001594A JP159483A JPS59128329A JP S59128329 A JPS59128329 A JP S59128329A JP 58001594 A JP58001594 A JP 58001594A JP 159483 A JP159483 A JP 159483A JP S59128329 A JPS59128329 A JP S59128329A
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- pentagalloylglucose
- drug
- antiviral agent
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003443 antiviral agent Substances 0.000 title claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 15
- QJYNZEYHSMRWBK-NIKIMHBISA-N 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose Chemical compound OC1=C(O)C(O)=CC(C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 QJYNZEYHSMRWBK-NIKIMHBISA-N 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 6
- 229920002793 1,2,3,4,6-Pentagalloyl glucose Polymers 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000003612 virological effect Effects 0.000 abstract description 3
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract description 2
- 244000236658 Paeonia lactiflora Species 0.000 abstract description 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract description 2
- 239000003463 adsorbent Substances 0.000 abstract description 2
- 238000002347 injection Methods 0.000 abstract description 2
- 239000007924 injection Substances 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract 2
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 240000005001 Paeonia suffruticosa Species 0.000 abstract 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- -1 j'9/-JL/ Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000000840 anti-viral effect Effects 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000002674 ointment Substances 0.000 description 5
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 241000736199 Paeonia Species 0.000 description 4
- 235000006484 Paeonia officinalis Nutrition 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 239000008311 hydrophilic ointment Substances 0.000 description 3
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- QXYJCZRRLLQGCR-UHFFFAOYSA-N dioxomolybdenum Chemical compound O=[Mo]=O QXYJCZRRLLQGCR-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000004200 microcrystalline wax Substances 0.000 description 2
- 235000019808 microcrystalline wax Nutrition 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 239000003871 white petrolatum Substances 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 235000014220 Rhus chinensis Nutrition 0.000 description 1
- 240000003152 Rhus chinensis Species 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960001067 hydrocortisone acetate Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58001594A JPS59128329A (ja) | 1983-01-07 | 1983-01-07 | 抗ウィルス剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58001594A JPS59128329A (ja) | 1983-01-07 | 1983-01-07 | 抗ウィルス剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59128329A true JPS59128329A (ja) | 1984-07-24 |
| JPH031289B2 JPH031289B2 (enrdf_load_stackoverflow) | 1991-01-10 |
Family
ID=11505829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58001594A Granted JPS59128329A (ja) | 1983-01-07 | 1983-01-07 | 抗ウィルス剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59128329A (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0959151A (ja) * | 1995-08-24 | 1997-03-04 | Kao Corp | ＮＦ−κＢ活性化抑制剤 |
| WO1998042350A1 (en) * | 1997-03-21 | 1998-10-01 | Cheil Jedang Corporation | Cholesterol lowering pharmaceutical composition |
| WO2003061554A3 (en) * | 2002-01-26 | 2003-11-13 | Micro Science Tech Co Ltd | Composition containing moutan root bark extract as active ingredient |
| KR100839099B1 (ko) | 2007-03-08 | 2008-06-19 | 원광대학교산학협력단 | 오배자 및 목단피 추출물을 함유하는 돼지 유행성 설사바이러스의 치료 및 예방용 조성물 |
| WO2009123183A1 (ja) * | 2008-03-31 | 2009-10-08 | 国立大学法人広島大学 | 抗ウイルス剤および抗ウイルス用組成物 |
| WO2010067869A1 (ja) * | 2008-12-12 | 2010-06-17 | 国立大学法人広島大学 | 抗ウイルス剤および抗ウイルス用組成物 |
| CN103012510A (zh) * | 2012-12-03 | 2013-04-03 | 北京工业大学 | 一种1,2,3,4,6-五没食子酰葡萄糖对照品的制备方法 |
| CN103800468A (zh) * | 2012-11-12 | 2014-05-21 | 天津瑞贝特科技发展有限公司 | 一种高蛋白营养免疫组合物及其制备方法 |
| CN103800524A (zh) * | 2014-01-19 | 2014-05-21 | 逯玲 | 一种治疗热毒炽盛型水痘的中药合剂 |
| KR101398426B1 (ko) * | 2007-03-16 | 2014-06-18 | 원광대학교산학협력단 | 항균 및 항바이러스 활성을 갖는 오배자 및 목단피추출물을 함유하는 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5791922A (en) * | 1980-11-27 | 1982-06-08 | Yasuo Tanaka | Antiviral agent of external use |
-
1983
- 1983-01-07 JP JP58001594A patent/JPS59128329A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5791922A (en) * | 1980-11-27 | 1982-06-08 | Yasuo Tanaka | Antiviral agent of external use |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0959151A (ja) * | 1995-08-24 | 1997-03-04 | Kao Corp | ＮＦ−κＢ活性化抑制剤 |
| WO1998042350A1 (en) * | 1997-03-21 | 1998-10-01 | Cheil Jedang Corporation | Cholesterol lowering pharmaceutical composition |
| WO2003061554A3 (en) * | 2002-01-26 | 2003-11-13 | Micro Science Tech Co Ltd | Composition containing moutan root bark extract as active ingredient |
| KR100839099B1 (ko) | 2007-03-08 | 2008-06-19 | 원광대학교산학협력단 | 오배자 및 목단피 추출물을 함유하는 돼지 유행성 설사바이러스의 치료 및 예방용 조성물 |
| KR101398426B1 (ko) * | 2007-03-16 | 2014-06-18 | 원광대학교산학협력단 | 항균 및 항바이러스 활성을 갖는 오배자 및 목단피추출물을 함유하는 조성물 |
| WO2009123183A1 (ja) * | 2008-03-31 | 2009-10-08 | 国立大学法人広島大学 | 抗ウイルス剤および抗ウイルス用組成物 |
| US9445605B2 (en) | 2008-03-31 | 2016-09-20 | Hiroshima University | Method for disinfection or infection control against a non-enveloped virus |
| JP2014012715A (ja) * | 2008-03-31 | 2014-01-23 | Hiroshima Univ | ロタウイルス属の非エンベロープウイルスに対する抗ウイルス剤および抗ウイルス用組成物 |
| JP5421901B2 (ja) * | 2008-03-31 | 2014-02-19 | 国立大学法人広島大学 | エンテロウイルス属の非エンベロープウイルスに対する抗ウイルス剤および抗ウイルス用組成物 |
| WO2010067869A1 (ja) * | 2008-12-12 | 2010-06-17 | 国立大学法人広島大学 | 抗ウイルス剤および抗ウイルス用組成物 |
| CN103800468A (zh) * | 2012-11-12 | 2014-05-21 | 天津瑞贝特科技发展有限公司 | 一种高蛋白营养免疫组合物及其制备方法 |
| CN103012510A (zh) * | 2012-12-03 | 2013-04-03 | 北京工业大学 | 一种1,2,3,4,6-五没食子酰葡萄糖对照品的制备方法 |
| CN103800524A (zh) * | 2014-01-19 | 2014-05-21 | 逯玲 | 一种治疗热毒炽盛型水痘的中药合剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH031289B2 (enrdf_load_stackoverflow) | 1991-01-10 |
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