JPS59116290A - 新規セフェム化合物およびその製造法 - Google Patents

新規セフェム化合物およびその製造法

Info

Publication number
JPS59116290A
JPS59116290A JP58220216A JP22021683A JPS59116290A JP S59116290 A JPS59116290 A JP S59116290A JP 58220216 A JP58220216 A JP 58220216A JP 22021683 A JP22021683 A JP 22021683A JP S59116290 A JPS59116290 A JP S59116290A
Authority
JP
Japan
Prior art keywords
cephem
carboxylic acid
acetamide
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58220216A
Other languages
English (en)
Japanese (ja)
Other versions
JPH051270B2 (enExample
Inventor
Takao Takatani
高谷　隆男
Takashi Masugi
馬杉　峻
Koji Kawabata
浩二 川端
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS59116290A publication Critical patent/JPS59116290A/ja
Publication of JPH051270B2 publication Critical patent/JPH051270B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP58220216A 1982-11-22 1983-11-22 新規セフェム化合物およびその製造法 Granted JPS59116290A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8233215 1982-11-22
GB8233215 1982-11-22

Publications (2)

Publication Number Publication Date
JPS59116290A true JPS59116290A (ja) 1984-07-05
JPH051270B2 JPH051270B2 (enExample) 1993-01-07

Family

ID=10534410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58220216A Granted JPS59116290A (ja) 1982-11-22 1983-11-22 新規セフェム化合物およびその製造法

Country Status (9)

Country Link
US (1) US4609730A (enExample)
EP (1) EP0109683B1 (enExample)
JP (1) JPS59116290A (enExample)
BE (1) BE898272A (enExample)
CH (1) CH659074A5 (enExample)
DE (1) DE3380696D1 (enExample)
FR (1) FR2537975B1 (enExample)
GB (1) GB2130582B (enExample)
IT (1) IT1175924B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
GB8411954D0 (en) * 1984-05-10 1984-06-13 Glaxo Group Ltd Cephalosporin antibiotics
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
JPS57116086A (en) * 1980-11-20 1982-07-19 Rhone Poulenc Ind 3-vinylcephalosporins and manufacture

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464369A (en) * 1977-03-14 1984-08-07 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
US4264597A (en) * 1978-06-06 1981-04-28 Masashi Hashimoto Cephalosporin analogues and processes for the preparation thereof
FR2457297A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
DK162718C (da) * 1982-09-30 1992-05-11 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser
US4492694A (en) * 1983-04-12 1985-01-08 Eli Lilly And Company Indolylglycyl cephalosporin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
JPS57116086A (en) * 1980-11-20 1982-07-19 Rhone Poulenc Ind 3-vinylcephalosporins and manufacture

Also Published As

Publication number Publication date
BE898272A (fr) 1984-05-21
EP0109683A2 (en) 1984-05-30
EP0109683B1 (en) 1989-10-11
EP0109683A3 (en) 1985-05-15
GB8330745D0 (en) 1983-12-29
CH659074A5 (de) 1986-12-31
GB2130582A (en) 1984-06-06
US4609730A (en) 1986-09-02
FR2537975B1 (fr) 1986-05-02
JPH051270B2 (enExample) 1993-01-07
GB2130582B (en) 1986-03-19
FR2537975A1 (fr) 1984-06-22
IT1175924B (it) 1987-08-12
DE3380696D1 (en) 1989-11-16
IT8323800A0 (it) 1983-11-21

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