JPS59101480A - 蛍光偏光免疫試験用試薬及び配位子測定法 - Google Patents

蛍光偏光免疫試験用試薬及び配位子測定法

Info

Publication number
JPS59101480A
JPS59101480A JP58208439A JP20843983A JPS59101480A JP S59101480 A JPS59101480 A JP S59101480A JP 58208439 A JP58208439 A JP 58208439A JP 20843983 A JP20843983 A JP 20843983A JP S59101480 A JPS59101480 A JP S59101480A
Authority
JP
Japan
Prior art keywords
ligand
tracer
antibody
mol
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58208439A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0475465B2 (enExample
Inventor
ジエ−ムズ・ロバ−ト・フイノ
カ−チス・リ−・キルケモ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JPS59101480A publication Critical patent/JPS59101480A/ja
Publication of JPH0475465B2 publication Critical patent/JPH0475465B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP58208439A 1982-11-08 1983-11-08 蛍光偏光免疫試験用試薬及び配位子測定法 Granted JPS59101480A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US440067 1982-11-08
US06/440,067 US4476229A (en) 1982-11-08 1982-11-08 Substituted carboxyfluoresceins

Publications (2)

Publication Number Publication Date
JPS59101480A true JPS59101480A (ja) 1984-06-12
JPH0475465B2 JPH0475465B2 (enExample) 1992-11-30

Family

ID=23747282

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58208439A Granted JPS59101480A (ja) 1982-11-08 1983-11-08 蛍光偏光免疫試験用試薬及び配位子測定法

Country Status (6)

Country Link
US (1) US4476229A (enExample)
EP (1) EP0108399B1 (enExample)
JP (1) JPS59101480A (enExample)
CA (1) CA1195996A (enExample)
DE (1) DE3373842D1 (enExample)
ES (1) ES8502548A1 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588697A (en) * 1979-09-07 1986-05-13 Syntex (U.S.A.) Inc. Method for performing fluorescent protein binding assay employing novel alkyl substituted fluorescent compounds and conjugates
US4652531A (en) * 1981-03-03 1987-03-24 Syntex (U.S.A.) Inc. Fluorescent protein binding assays with unsymmetrical fluorescein derivatives
US4585862A (en) * 1981-12-11 1986-04-29 Abbott Laboratories Fluorescence polarization immunoassay
US4614823A (en) * 1982-11-08 1986-09-30 Abbott Laboratories Aminomethylfluorescein derivatives
US5089388A (en) * 1983-04-19 1992-02-18 Syntex (U.S.A.) Inc. Antibodies for salicylate and their preparation
US4595656A (en) * 1984-01-06 1986-06-17 Becton Dickinson & Company Coupling agents and products produced therefrom
US4591569A (en) * 1984-04-11 1986-05-27 Becton Dickinson & Company Homogeneous fluorescent triiodothyronine uptake test
US4665020A (en) * 1984-05-30 1987-05-12 United States Department Of Energy Flow cytometer measurement of binding assays
EP0218010A3 (en) * 1985-07-10 1988-01-07 Abbott Laboratories Ligand detection method and substituted carboxyfluorescein tracers therefor
DE3689688T2 (de) * 1985-10-15 1994-08-25 Abbott Lab Verbindungen und Immunoassay für tricyclische Antidepressiva.
US4803157A (en) * 1986-01-31 1989-02-07 Eastman Kodak Company Hydrolyzable fluorescent substrates for phosphatases and analytical use thereof
US5336622A (en) * 1986-04-25 1994-08-09 Abbott Laboratories Tracers for use in flecainide fluorescence polarization immunoassay
US5221629A (en) * 1986-05-21 1993-06-22 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US5155212A (en) * 1986-05-21 1992-10-13 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
US5124457A (en) * 1986-05-21 1992-06-23 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US5102808A (en) * 1986-06-05 1992-04-07 Board Of Governors Of Wayne State University Method and test kit for analysis of histamine receptor sites of mammalian cells
US5145791A (en) * 1986-07-09 1992-09-08 Abbott Laboratories 3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay
US4939264A (en) * 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US4784961A (en) * 1987-03-23 1988-11-15 Abbott Laboratories Fluorescence polarization method for monitoring fetal lung maturity
US5223627A (en) * 1986-07-15 1993-06-29 Abbott Laboratories Fluorescence polarization method for monitoring fetal lung maturity
US4868132A (en) * 1987-02-03 1989-09-19 Abbott Laboratories Fluorescence polarization immunoassay for amphetamine/methamphetamine
US5264373A (en) * 1987-02-17 1993-11-23 Abbott Laboratories Fluorescence polarization immunoassay for tetrahydrocannabinoids
US5144030A (en) * 1987-02-17 1992-09-01 Abbott Laboratories Fluorescene polarization immunoassay for tetrahydrocannabinoids
US5427960A (en) * 1987-03-27 1995-06-27 Abbott Laboratories Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US4970074A (en) * 1987-06-29 1990-11-13 Abbott Laboratories Fluorophores for encapsulation into liposomes
US4912208A (en) * 1987-06-29 1990-03-27 Abbott Laboratories Fluorophores for encapsulation into liposomes
US4894348A (en) * 1987-07-01 1990-01-16 Ronald Robert C Fluorescein-conjugated proteins with enhanced fluorescence
US5100807A (en) * 1987-10-19 1992-03-31 Abbott Laboratories Phenylacetylglutamine (pag) analytical test
US5262333A (en) * 1988-10-28 1993-11-16 Abbott Laboratories Method and reagents for detecting amphetamine and/or D-methamphetamine in biological samples
US5073629A (en) * 1989-01-23 1991-12-17 Abbott Laboratories Methadone fluorescence polarization immunoassay
US5248791A (en) * 1989-04-10 1993-09-28 Abbott Laboratories Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay
US5101015A (en) * 1989-04-10 1992-03-31 Abbott Laboratories Reagents for an amphetamine-class fluorescence polarization immunoassay
US5512659A (en) * 1989-08-04 1996-04-30 Syntex (U.S.A.) Inc. Compositions useful in heterogeneous immunoassays
US5096838A (en) * 1989-11-27 1992-03-17 Abbott Laboratories Barbiturate assay compositions and methods
US5099020A (en) * 1989-11-27 1992-03-24 Abbott Laboratories Barbiturate assay compositions and methods
US5055594A (en) * 1990-07-19 1991-10-08 Becton, Dickinson And Company Fluorogenic trypotophanase substrates
US5352803A (en) * 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
EP0649533B1 (en) * 1992-03-30 2000-05-10 Abbott Laboratories Reagents and methods for the detection and quantification of thyroxine in fluid samples
US5543311A (en) * 1992-08-07 1996-08-06 Johnson & Johnson Clinical Diagnostics, Inc. Labeled carbamazepine hapten analogues for competitive enzyme immunoassays
US5578457A (en) * 1992-08-07 1996-11-26 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassays with novel labeled carbamazepine hapten analogues
US5315015A (en) * 1992-11-10 1994-05-24 Hoffmann-La Roche Inc. Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US7083984B2 (en) * 1993-09-24 2006-08-01 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US5476939A (en) * 1993-12-30 1995-12-19 Abbott Laboratories Certain pyridyl and isoquinolyl carbinolamine derivatives
US6110750A (en) * 1996-06-28 2000-08-29 Sugden; Edward A. Rapid detection method of Mycobacterium bovis by fluorescence polarization
DE10032633A1 (de) * 2000-07-05 2002-01-17 Bayer Ag Verfahren zum Auffinden von Hemmstoffen der Protoporphyrinogen-Oxidase
US7163918B2 (en) * 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
US6482601B1 (en) * 2000-09-11 2002-11-19 Diachemix Llc Fluorescence polarization-based homogeneous assay for fumonisin determination in grains
US7399639B2 (en) * 2003-05-04 2008-07-15 Massachusetts Institute Of Technology Sensors, and methods of making and using the same
US9006283B2 (en) * 2007-07-12 2015-04-14 Acumen Pharmaceuticals, Inc. Methods of modifying amyloid β oligomers using non-peptidic compounds
US20110098309A1 (en) * 2007-07-12 2011-04-28 Acumen Pharmaceuticals, Inc. Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds
US8962677B2 (en) * 2007-07-12 2015-02-24 Acumen Pharmaceuticals, Inc. Methods of restoring cognitive ability using non-peptidic compounds
CA2707309A1 (en) 2007-12-18 2009-06-25 Acumen Pharmaceuticals, Inc. Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production
KR101847748B1 (ko) 2013-08-22 2018-04-10 소니 주식회사 수용성 형광 또는 유색 염료 및 그의 사용 방법
US11084932B2 (en) 2015-02-26 2021-08-10 Sony Group Corporation Phenylethynylnaphthalene dyes and methods for their use
CN107454903B (zh) * 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
JP6849599B2 (ja) 2015-05-11 2021-03-24 ソニー株式会社 超明色ダイマーまたはポリマー染料
WO2017173348A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
CA3018564C (en) 2016-04-01 2024-04-23 Sony Corporation Ultra bright dimeric or polymeric fluorescent and colored dyes
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
EP3455299B1 (en) 2016-05-10 2024-01-17 Sony Group Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
CN109071961B (zh) 2016-05-11 2021-04-27 索尼公司 超亮二聚或聚合染料
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
JP7312929B2 (ja) 2016-07-29 2023-07-24 ソニーグループ株式会社 超明色二量体またはポリマー色素およびその調製のための方法
EP3691690B1 (en) 2017-10-05 2024-08-14 Sony Group Corporation Programmable polymeric drugs
CN111093711A (zh) 2017-10-05 2020-05-01 索尼公司 可编程的树枝状药物
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
JP2021510696A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
JP2021520423A (ja) 2018-03-19 2021-08-19 ソニーグループ株式会社 蛍光シグナルを増強するための二価金属の使用
JP7515786B2 (ja) 2018-03-21 2024-07-16 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
WO2020006285A1 (en) 2018-06-27 2020-01-02 Sony Corporation Polymeric dyes with linker groups comprising deoxyribose
KR102718543B1 (ko) 2019-09-26 2024-10-18 소니그룹주식회사 링커 그룹을 갖는 중합체성 탠덤 염료
CN111606919B (zh) * 2020-05-22 2021-10-15 北京诺康达医药科技股份有限公司 一种羧基荧光素琥珀酰亚胺酯的溶剂化物及其制备方法
WO2022125564A1 (en) 2020-12-07 2022-06-16 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55119061A (en) * 1979-03-05 1980-09-12 Syva Co Method of analyzing competitive protein linkage while preventing nonnspecific interference
JPS57150680A (en) * 1981-02-17 1982-09-17 Abbott Lab Fluorescent polarization immunodetermination employing substituted carboxyfluorescein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161515A (en) * 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
US4171311A (en) * 1978-01-16 1979-10-16 International Diagnostics Tech. Inc. Imides of thyroxin and triiodothyronine
CA1160626A (en) * 1980-07-30 1984-01-17 Stephen D. Stroupe Biologically interesting compounds labeled with dichlorotriazinyl-aminofluorescein
US4347059A (en) * 1980-09-15 1982-08-31 Beckman Instruments, Inc. T3 Uptake polarization fluoroimmunoassay
US4347058A (en) * 1980-09-15 1982-08-31 Beckman Instruments, Inc. Thyroid polarization fluoroimmunoassay
NZ199629A (en) * 1981-02-17 1984-11-09 Abbott Lab Fluorescent polarisation immunoassay and certain substituted carboxy fluoresceins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55119061A (en) * 1979-03-05 1980-09-12 Syva Co Method of analyzing competitive protein linkage while preventing nonnspecific interference
JPS57150680A (en) * 1981-02-17 1982-09-17 Abbott Lab Fluorescent polarization immunodetermination employing substituted carboxyfluorescein

Also Published As

Publication number Publication date
US4476229A (en) 1984-10-09
EP0108399A3 (en) 1984-06-13
JPH0475465B2 (enExample) 1992-11-30
DE3373842D1 (en) 1987-10-29
ES527083A0 (es) 1985-01-01
ES8502548A1 (es) 1985-01-01
EP0108399A2 (en) 1984-05-16
EP0108399B1 (en) 1987-09-23
CA1195996A (en) 1985-10-29

Similar Documents

Publication Publication Date Title
JPS59101480A (ja) 蛍光偏光免疫試験用試薬及び配位子測定法
US4510251A (en) Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers
US4668640A (en) Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
US5391740A (en) Fluoresence polarization immunoassay
US4902630A (en) Fluorescence polarization immunoassy and reagents for measurement of c-reactive protein
JP4163869B2 (ja) 検出方法
GB2111476A (en) Substituted carboxy- fluoresceins and their use in fluorescence polarization immunoassay
RU2559581C2 (ru) Иммунологические исследования с использованием недисперсного хемилюминесцентного реактива
US4614823A (en) Aminomethylfluorescein derivatives
JPS63258491A (ja) サイクロスポリンa誘導体およびそれを用いたサイクロスポリンaまたはその代謝産物の蛍光偏光イムノアッセイ法
JPS6214064A (ja) 置換カルボキシフルオレセイン
EP0201751A2 (en) 4'-aminomethyfluorescein derivatives for use in fluorescence polarization immunoassys
JP4213029B2 (ja) 特異的標識化方法
CA1178269A (en) Fluorescent polarization immunoassay utilizing substituted carboxyfluoresceins
US5066426A (en) Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
CA2167321C (en) Reagents and methods for the detection and quantification of testosterone in fluid samples
US4952691A (en) Fluorescence polarization immunoassay
CA1248086A (en) Fluorescence polarization immunoassay
EP0380019B1 (en) Methadone fluorescence polarization immunoassay
JPS59101481A (ja) 置換カルボキシフルオレセイン
Hong et al. Development of one-step fluorescence polarization immunoassay for progesterone
JP2009522581A (ja) 競合免疫アッセイによるfk778の濃度の決定
BR112015013652B1 (pt) Derivados de testosterona com uma substituição carboxialquila na posição 3, seus usos, conjugado, kit e métodos para preparar um derivado de testosterona e para determinar a concentração de testosterona em uma amostra biológica
US5580741A (en) Chemiluminescence immunoassay for chlorinated aromatic compound detection
JPS63500399A (ja) アナライトが存在可能な媒体中のアナライトをルミネセンスによって検出および/または測定するための均質方法およびその方法に使用するキット