JPS5857308A - 発毛，養毛剤 - Google Patents
発毛，養毛剤Info
- Publication number
- JPS5857308A JPS5857308A JP56155492A JP15549281A JPS5857308A JP S5857308 A JPS5857308 A JP S5857308A JP 56155492 A JP56155492 A JP 56155492A JP 15549281 A JP15549281 A JP 15549281A JP S5857308 A JPS5857308 A JP S5857308A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- reductase
- agent
- testosterone
- theory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004209 hair Anatomy 0.000 title abstract description 121
- 210000001732 sebaceous gland Anatomy 0.000 claims abstract description 34
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 16
- 108090000854 Oxidoreductases Proteins 0.000 claims abstract description 6
- 230000003779 hair growth Effects 0.000 claims description 30
- 230000009471 action Effects 0.000 claims description 11
- 230000001256 tonic effect Effects 0.000 claims description 4
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract description 52
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 abstract description 32
- 229960003604 testosterone Drugs 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 17
- 229940088597 hormone Drugs 0.000 abstract description 17
- 239000005556 hormone Substances 0.000 abstract description 17
- 239000004155 Chlorine dioxide Substances 0.000 abstract description 16
- 239000003795 chemical substances by application Substances 0.000 abstract description 16
- 235000019398 chlorine dioxide Nutrition 0.000 abstract description 16
- 238000011069 regeneration method Methods 0.000 abstract description 9
- 230000008929 regeneration Effects 0.000 abstract description 7
- XWNSFEAWWGGSKJ-UHFFFAOYSA-N 4-acetyl-4-methylheptanedinitrile Chemical compound N#CCCC(C)(C(=O)C)CCC#N XWNSFEAWWGGSKJ-UHFFFAOYSA-N 0.000 abstract description 6
- 201000004384 Alopecia Diseases 0.000 abstract description 6
- 239000004153 Potassium bromate Substances 0.000 abstract description 6
- 230000032823 cell division Effects 0.000 abstract description 6
- 230000003676 hair loss Effects 0.000 abstract description 6
- 239000007800 oxidant agent Substances 0.000 abstract description 6
- 229940094037 potassium bromate Drugs 0.000 abstract description 6
- 235000019396 potassium bromate Nutrition 0.000 abstract description 6
- 230000002255 enzymatic effect Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- RSIHSRDYCUFFLA-DYKIIFRCSA-N boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 abstract 1
- RSIHSRDYCUFFLA-UHFFFAOYSA-N dehydrotestosterone Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 RSIHSRDYCUFFLA-UHFFFAOYSA-N 0.000 abstract 1
- -1 etc. Substances 0.000 abstract 1
- 210000001550 testis Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 32
- 239000011159 matrix material Substances 0.000 description 31
- 210000003780 hair follicle Anatomy 0.000 description 18
- 230000018109 developmental process Effects 0.000 description 13
- 210000004761 scalp Anatomy 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- 230000012010 growth Effects 0.000 description 8
- 230000031774 hair cycle Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000003163 gonadal steroid hormone Substances 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 210000002374 sebum Anatomy 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000002500 effect on skin Effects 0.000 description 5
- 230000001590 oxidative effect Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000003660 hair regeneration Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 150000003515 testosterones Chemical class 0.000 description 4
- 210000004602 germ cell Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- ODFCWXVQZAQDSO-CMKODMSKSA-N (2s,4as,10ar)-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-2,6-diol Chemical compound CC([C@@H]1CC2)(C)[C@@H](O)CC[C@]1(C)C1=C2C=C(C(C)C)C(O)=C1 ODFCWXVQZAQDSO-CMKODMSKSA-N 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- 235000002568 Capsicum frutescens Nutrition 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- 241001247145 Sebastes goodei Species 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 230000005200 bud stage Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000003797 telogen phase Effects 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- CYTCTRAEJYIZRX-UHFFFAOYSA-N (9a-hydroxy-3,5a-dimethyl-9-methylidene-2-oxo-3,3a,4,5,6,7,8,9b-octahydrobenzo[g][1]benzofuran-6-yl) acetate Chemical compound C1CC2(C)C(OC(C)=O)CCC(=C)C2(O)C2C1C(C)C(=O)O2 CYTCTRAEJYIZRX-UHFFFAOYSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 241000036318 Callitris preissii Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 241000277269 Oncorhynchus masou Species 0.000 description 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56155492A JPS5857308A (ja) | 1981-09-30 | 1981-09-30 | 発毛，養毛剤 |
| AU88805/82A AU566402B2 (en) | 1981-09-30 | 1982-09-28 | Sebaceous gland reductase inhibition |
| DE8282305156T DE3272907D1 (en) | 1981-09-30 | 1982-09-29 | Hair growing agent or hair tonic |
| CA000412513A CA1232545A (en) | 1981-09-30 | 1982-09-29 | Hair growing agent or hair tonic |
| EP19820305156 EP0076159B1 (en) | 1981-09-30 | 1982-09-29 | Hair growing agent or hair tonic |
| ZA827166A ZA827166B (en) | 1981-09-30 | 1982-09-30 | Hair growing agent or hair tonic |
| BR8205750A BR8205750A (pt) | 1981-09-30 | 1982-09-30 | Tonico capilar ou agente de crescimento de cabelo |
| SG78287A SG78287G (en) | 1981-09-30 | 1987-09-23 | Hair growing agent or hair tonic |
| MY8700897A MY8700897A (en) | 1981-09-30 | 1987-12-30 | Hair growing agent or hair tonic |
| HK32288A HK32288A (en) | 1981-09-30 | 1988-05-02 | Hair growing agent or hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56155492A JPS5857308A (ja) | 1981-09-30 | 1981-09-30 | 発毛，養毛剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5857308A true JPS5857308A (ja) | 1983-04-05 |
| JPH0140004B2 JPH0140004B2 (enrdf_load_stackoverflow) | 1989-08-24 |
Family
ID=15607224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56155492A Granted JPS5857308A (ja) | 1981-09-30 | 1981-09-30 | 発毛，養毛剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5857308A (enrdf_load_stackoverflow) |
| ZA (1) | ZA827166B (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58121206A (ja) * | 1982-01-12 | 1983-07-19 | Kenichi Arakawa | 発毛，養毛促進液剤 |
| JPS5921610A (ja) * | 1982-07-29 | 1984-02-03 | Inaba Heaa Res Kk | 発毛，養毛剤 |
| JPS6157944U (enrdf_load_stackoverflow) * | 1984-09-25 | 1986-04-18 | ||
| US4885289A (en) * | 1983-12-12 | 1989-12-05 | Breuer Miklos M | Alteration of character of male beard growth |
| US5411991A (en) * | 1992-12-22 | 1995-05-02 | Shander; Douglas | Method of reducing hair growth employing sulfhydryl active compounds |
| US6743419B1 (en) | 1992-12-22 | 2004-06-01 | The Gillette Company | Method of reducing hair growth employing sulfhydryl active compounds |
| JP2016500114A (ja) * | 2012-11-29 | 2016-01-07 | 劉学武 | 哺乳類の幹細胞に作用する方法と、哺乳類の幹細胞に作用する薬物の応用において調製、使用される二酸化塩素 |
-
1981
- 1981-09-30 JP JP56155492A patent/JPS5857308A/ja active Granted
-
1982
- 1982-09-30 ZA ZA827166A patent/ZA827166B/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58121206A (ja) * | 1982-01-12 | 1983-07-19 | Kenichi Arakawa | 発毛，養毛促進液剤 |
| JPS5921610A (ja) * | 1982-07-29 | 1984-02-03 | Inaba Heaa Res Kk | 発毛，養毛剤 |
| US4885289A (en) * | 1983-12-12 | 1989-12-05 | Breuer Miklos M | Alteration of character of male beard growth |
| JPS6157944U (enrdf_load_stackoverflow) * | 1984-09-25 | 1986-04-18 | ||
| US5411991A (en) * | 1992-12-22 | 1995-05-02 | Shander; Douglas | Method of reducing hair growth employing sulfhydryl active compounds |
| US6743419B1 (en) | 1992-12-22 | 2004-06-01 | The Gillette Company | Method of reducing hair growth employing sulfhydryl active compounds |
| JP2016500114A (ja) * | 2012-11-29 | 2016-01-07 | 劉学武 | 哺乳類の幹細胞に作用する方法と、哺乳類の幹細胞に作用する薬物の応用において調製、使用される二酸化塩素 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0140004B2 (enrdf_load_stackoverflow) | 1989-08-24 |
| ZA827166B (en) | 1984-04-25 |
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