JPS5857308A - Agent for growing and nourishing hair - Google Patents

Abstract

PURPOSE:An agent for growing and nourishing hair containing an oxidizing agent as an active ingredient such as stabilized chlorine dioxide, potassium bromate, etc., substances to suppress or to prevent an enzymatic action of 5alpha reductase, a reductase, occurring in the sebaceous gland. CONSTITUTION:An agent for growing and nourishing hair containing an oxidizing agent such as stabilized chlorine dioxide, potassium bromate, etc. as an active ingredient. Testosterone, male hormone, is formed by the testicles, sent directly to the sebaceous gland by the circulation, and converted by 5alpha reductase, a reductase occurring in the sebaceous gland, into 5alpha dehydrotestosterone, strong male hormone, which suppresses the cell division of hair metrocyte to form baldness. The agent for growing and nourishing hair suppresses the activity of 5alpha reductase, a reductase, contained in it, and promotes the nourishment and regeneration of hair. The amount of the stabilized chlorine dioxide used is preferably 250ppm.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair growth and hair growth agent that causes love hair in bald areas to grow into normal terminal hair.

Baldness is a state in which terminal hair grows, becomes thinner and smaller each time it changes, and is not caused by a complete loss of the function of a single hair follicle, but various explanations have been given for the cause.

A typical example of this is that sebum from the sebaceous glands is shunted to an increased level, mixes with scalp grime, becomes hot on the skin, and clogs the pores, causing nutritional and circulatory problems for the hair roots.
(Sebum theory), or because male hormones (testosterone) are overproduced, creating an imbalance in the top of the head, which was previously controlled by the balance of male and female hormones (hormone theory), or Although a relationship between genetics and nutrition has been suggested, none of these can be considered a definitive cause.

This is because the above-mentioned theories are based on the conventional dermatological dogma regarding the development of hair, that is, when a bulb is formed on the skin, hair matrix cells are formed inside it.

This is due to the established theory that differentiation begins from this a follicle and gradually keratinizes to become hair.

Under these circumstances, conventionally used hair growth or hair growth agents have been aimed only at improving blood circulation (3JI) in the hair bulb. For example, hinokiol.

The main ingredient is an aqueous solution such as menthol or chili pepper tincture, which is applied to the scalp to maintain good blood circulation in the scalp.
As a secondary measure, it aims to improve blood circulation in the bulb area and is expected to encourage hair growth or regeneration, but it is difficult to create sufficient sound effects for masculinity.

The present invention was completed based on a new theory of hair development that was researched by the inventor for many years and has been recognized worldwide, unlike the conventional established theory regarding hair development as described above. is essential for understanding the present invention, so the major g! Explain.

FIG. 1 is an explanatory diagram of the hair cycle according to this theory.

In other words, two hair follicles and the sebaceous glands attached to them constitute one cella, and during the growth period nine hairs are formed from the hair matrix cells of the bulb. However, instead of continuing to grow forever, the hair passes through a transition period t-, enters a resting period, and then the hair is pulled out and secondary regeneration begins. This is the hair cycle.

The conventional theory is that regeneration begins at the lower end of this resting phase, but according to the inventor's theory of new hair generation, hair buds originate from the isthmic hair sheath, which is the outlet of the sebaceous gland excretion tube. formed (hair bud M).

Hair is formed from the epithelial germ cells at the bottom of the hair follicle and descends while producing two hairs (hair pile stage), after which a bulb is formed. However, until the hair matrix cells are formed in this bulb, it is still declining (the bulb hair pile stage).

When the hair matrix cells reach their full potential, they stop descending and hair emerges only on the surface of the skin (on completion). In this way, 9 hair is not only formed from hair matrix cells in the bulb area, but also from epithelial cells of the hair follicle, similar to the 2 epidermis, and the sebaceous glands are an important base for hair formation. This fact has been accepted both domestically and internationally as a new theory (sebaceous gland theory or Fi, SS theory) regarding the development of double hair.

On the other hand, testosterone, a male hormone involved in the growth of hair, is formed in the red pill, and conventionally the chain in Figure 2! (a)
As shown in , it was thought to act directly on the hair matrix cells from the dermal papilla in the bulb.

In contrast, the present inventor argues that this testosterone is transported directly to the sebaceous glands by blood circulation, not to the bulb area (b)
is reduced by the reductase 5α reductase present in the sebaceous gland and converted into 5α dihydrotestosterone (hereinafter referred to as 5αDHTJ), a powerful sex hormone. It has a completely new theory that it is transported to (C)1 and suppresses the cell division of hair matrix cells.

Therefore, when the sebaceous glands enlarge due to the influence of nutrients and hormones, the amount of 5α-reductase increases, and testosterone is converted to the powerful sex hormone 5αDHT, which gradually shrinks the hair follicles and causes the hair to grow thicker and cause baldness. It becomes a state. Thus, while testosterone itself promotes hair production, the converted 5αD
Because HT's action is so strong, it acts in a suppressive manner on bihair matrix cells, in the same way that giving too much fertilizer to a plant inhibits its growth.

The present invention is based on the above-mentioned baldness formation process, and if the enzymatic action of 5α reductase present in the sebaceous glands is inhibited, testosterone will not be converted to the powerful sex hormone 5αDHT, and therefore, it will not affect the hair matrix cells. Focusing on the fact that the inhibitory effect weakens or disappears, the main idea is to include a substance that suppresses or eliminates the action of 5α reductase present in the sebaceous glands in a hair growth and hair growth agent.

Since it uses a reducing enzyme from 5α Reductase Co., Ltd., in order to attenuate or eliminate this activity, it must have a strong oxidizing effect, be harmless to the human body, and not cause any side effects.

Examples of such substances include stabilized chlorine dioxide, nitrosine, potassium bromate, which is used as the second liquid in chlorine, and ozone; however, as long as the above two conditions are met, other oxidizing agents may not be used. Substances can be used, and the examples in #J are not intended to be limiting.

Next, a practical example using stabilized chlorine dioxide will be shown.

Stabilized chlorine dioxide 250 pp, m.

Ethyl alcohol 20 CC Fragrance 0.03 G' Above hair growth,
Apply hair tonic 'k on your bald scalp 2-3 times a day, massage lightly and use continuously.

Through this artc, various oxidizing substances penetrate into the sebaceous glands through the pores of the scalp and attenuate or eliminate the activity of 5α-reductase present in the sebaceous glands. Therefore, the action of only testosterone acts on the hair follicle without being converted to testosterone Fi and 5αDHT carried from the knitting pill. Even if some testosterone is converted to 5αDHT.

The effects of the present invention are not impaired because the amount of testosterone that acts on hair matrix cells is significantly higher than that of the testosterone.

This testosterone Fi has good results for scalp hair as well as hair growth after puberty in men, such as beards and chest hair, and as shown in the hair regeneration process diagram mentioned above, hair follicles are grown and formed. Active cell division of the hair follicle VC occurs and the terminal hair develops into an adult.

As mentioned above, the present invention is based on new research results on the process of hair development, and conventional hair growth and hair growth agents are used to treat malnutrition in the bulb area.

J) / In contrast to trying to remove and improve factors such as circulatory disorders
The present invention suppresses and eliminates the action of the reductase 5α reductase present in the sebaceous glands, prevents the conversion to 1-potent 5αDHT, and secondarily removes the factor that completely inhibits cell division of hair matrix cells, allowing normal testosterone levels to be restored. It acts on hair matrix cells to fully promote their division, and has an unprecedented effect on turning curly hair in bald areas into terminal hair.

[Brief explanation of the drawing]

FIG. 1 is an explanatory diagram of the hair cycle on which the present invention is based. FIG. 2 is an explanatory diagram of the action pathway of the male hormone testosterone. Patent Applicant: Masumi Inaba, Patent Attorney, Katsuyama Michi Procedural Amendment (Method) March 1980-24, Commissioner of the Japan Patent Office Shima 1) Haruki Tono1, Indication of Case 1982τ1. Patent Application No. 155492 3, Relationship with the case of the person making the amendment Patent applicant: Masu Inaba (self 4, attorney 6) Number of inventions increased by amendment No 1),
(TI) (II) (N) (V) (■)
(■) Procedural amendment (voluntary) March 24, 1980 Commissioner of the Japan Patent Office Shima 1) Haru Judono 1゜ case representation 1981 Patent Application No. 155492 3 Relationship with party P1 making the amendment Patent Applicant 4 Agent 6, Number of inventions increased by amendment None 1) Page 3, line 5 of the specification in the “Detailed Description of the Invention” column “Figure 1 is...
"..." to "..." on page 4, line 3, "..." is amended as follows to match the explanatory symbols in the attached drawings. "Figure 1 is an explanatory diagram of the hair cycle according to this theory. In other words, one hair follicle (1) and the sebaceous gland (2
) and become one set, and during the growth stage ill, one hair is formed from the hair matrix cell (4) of the bulb part (3). However, it does not continue to grow permanently, but in the transition stage tut After passing through the telogen phase tll11, the hair is pulled out and the first regeneration begins.This is the hair cycle.The conventional theory is that regeneration starts from the lower end of the telogen phase fil, but the inventors' new hair According to the developmental theory, hair buds are formed from the isthmic hair sheath (5), which is the outlet of the excretory tube of the sebaceous gland (2) (hair bud stage + IVl).
, Hair is formed from the L-adult germ cells at the bottom of the hair follicle, and the hair descends while producing 9 hairs (fV]). After that a light bulb is formed. However, until the hair matrix cells are formed in this bulb, the descent continues until the hair matrix cells are formed, and once the hair matrix cells are fully functional, the descent stops and the hair matrix begins to move toward the skin surface. Only Iζ hair comes out (completed hair (■)). ”(2)
Page 4, line 10 of the specification in the same column “Other 5...”
5. The statement from line 13 of the same page, ``It was seen...'' is amended as follows. On the other hand, testosterone, which is a male hormone involved in hair growth, is formed in the Akamaru TM+, and conventionally, as shown by the chain line tal in Figure 2, it is directly transmitted to the dermal papilla (3) of the bulb (3).
All three were thought to act on hair matrix cells. ”(3
) In the same column, page 4, line 15 of the specification, the phrase "in the sebaceous glands" is amended to "in the sebaceous glands (2)." Patent Officer Kazuo Wakasugi 1, Indication of the case, Patent Application No. 155492/1982, Title of the invention: Hair growth, hair tonic 3, Relation to the Supplement + E case Patent applicant Masumi Inaba 4, Attorney Person 5, the entire text of the voluntarily amended specification and Figure 1.2 are corrected as attached 2- Description 1, Title of the invention, hair growth, hair tonic 2, Claims (1) Reductase 5α present in sebaceous glands vinegar! 1. A hair growth agent characterized by containing a substance that suppresses or eliminates the enzymatic activity of lactase as an active ingredient. (2) The hair growth and hair growth agent according to claim 1, wherein the substance is an oxidizing agent. (3) Claim 2, wherein the oxidizing agent is at least one selected from stabilized chlorine dioxide and potassium bromate.
Hair growth and hair growth agent as described in section. (4) The hair growth and hair growth agent according to claim 3, wherein the content of stabilized chlorine dioxide is 250 ppm. 3. Detailed Description of the Invention The present invention relates to a hair growth and hair growth agent that causes the love hair in the prominent areas to grow into normal terminal hair. When the terminal hair grows back, it gets smaller and smaller, and it is in a love-electrified state where the function of one hair follicle is fulfilled. +1 Although it has not completely disappeared, various explanations have been given for its causes. A typical example of this is that sebum secretion from the sebaceous glands increases and mixes with scalp grime, resulting in seborrhea, which clogs the pores and causes nutritional and circulatory problems for the hair roots.
seborrhea theory). This may be due to excessive production of male hormones (testosterone), leading to an imbalance in the male and female sex hormones (hormone theory), which was previously dominated by the male and female sex hormones (hormone theory), or a relationship with genetics and nutrition. However, none of these could be considered to be the definitive cause. This is because the above theories are based on the conventional erroneous dermatological dogma regarding the development of hair, that is, there are bulbs on the skin. This is due to the established theory that when hair is formed, hair matrix cells are formed inside it, and these cells begin to differentiate and undergo #i-order keratinization to become hair. The main purpose of hair growth or hair toning agents is to improve blood circulation in the bulb area.1 For example, they are mainly aqueous solutions such as hinokiol, menthol, and chili pepper tincture, which can be applied to the scalp to improve blood circulation in the scalp. The present invention is aimed at improving the blood circulation in the light bulb area and secondarily improving the blood circulation in the light bulb area, which is expected to result in hair growth or regeneration. Unlike the conventional theory regarding the development of hair, the present inventor has conducted research for many years.As a result,
It was completed based on the discovered new theory of hair development, and since this development theory is essential for understanding the present invention, its outline will be explained below. FIG. 1 is an explanatory diagram of the hair cycle according to this theory. That is, the hair follicle 3 and the sebaceous gland 1 attached to it are 1
During the growth period (A), one hair is formed from the hair matrix cells 5 of the bulb portion 4. However, it does not continue to grow permanently (; it does not continue to grow), but it is in a transitional period (B
)'e, the body stops (q1=), the hair is pulled out, and the next regeneration begins. This is the hair cycle. According to the conventional theory, regeneration begins from the lower end of the hair follicle 3 during this resting period ( However, according to the new theory of hair development proposed by the present inventor, hair buds are formed from the isthmus 2, which is the outlet of the excretory tube of sebum I!!1 (hair bud stage (11)).
Hair is formed from the epithelial germ cell layer at the bottom of the hair bun 3, and as the hair is being formed, it descends until the hair pile is formed, and then the bulb is formed. However, until the hair matrix cells 5 are formed in this bulb part 4, the S declines and the bulb hair pile stage (1') occurs.
), that hair mother! When the fI follicle 5 becomes fully functional, it stops descending and hair comes out only on the surface of the skin (the completed system ((1)). Like this. The fact that hair 1 is formed not only from cells 5 but also from the epithelial cells of hair follicles like the epidermis 1, and that the sebum 811 is an important base for hair formation. This is a new theory regarding development (sebaceous gland theory or Inaba theory) that has been accepted both domestically and internationally.On the other hand, testosterone, the male hormone related to hair growth, is formed in one circle and eight, and conventionally the chain line in Figure 2 ( IL
), it was thought to act directly on the hair matrix cells 5 from the dermal papilla 7 of the bulb portion 4. On the other hand, the present inventor has found that this testosterone is
In addition, it is directly transported to sebum I11 by blood circulation (solid line b), and is reduced by the reductase 5α reductase present in the sebaceous gland 1, producing 5α deinohydrothystosterone (hereinafter referred to as “5αDHT”), a powerful hormone.
Next, this 5aDHT is transferred to the dermal papilla 7. by the blood vessels around the hair follicle. transported to hair matrix cells 5 (0
), we discovered a completely new theory that it suppresses the cell division of hair matrix cells 5. Therefore, when the sebaceous glands become enlarged due to the influence of nutrients and hormones, the amount of 5α reductase increases. Testosterone is converted to the powerful sex hormone 5αDHT, and the color of the hair gradually shrinks, turning the hair into rough hair and causing baldness.This is how: Testosterone itself or a small amount of 5αDHT promotes hair production. However, this was transferred to various companies5 (! DHT has such a strong effect that it has a negative impact on one hair matrix cell, just as excessive fertilizers inhibit the growth of plants. The present invention is based on the above-mentioned process of baldness formation.If the enzymatic action of the 5α reductase present in the sebaceous glands is suppressed, testosterone becomes a powerful sex hormone 5.
It is rarely converted to αDHT. Therefore, focusing on the fact that the inhibitory effect on hair matrix cells weakens or disappears, we have included a substance that suppresses or eliminates the action of 5α reductase present in the sebaceous glands in hair growth and hair growth agents. The gist is that. Up to now, attempts have been made to use competitive antagonists such as progestin and other male hormones for the purpose of suppressing the activity of 5α-reductase, but these have many side effects and are not suitable as 5-hair growth agents. Since 5α-reductase is a reducing enzyme, the first method for attenuating or eliminating this activity is to use a substance that has a strong oxidizing effect, is harmless to the human body, and does not cause side effects. I found out. Such substances include, for example, stabilized chlorine dioxide, potassium bromate used as the second liquid of coal tonoma, and ozone; however, as long as the above two conditions are met, other oxidizing substances may be used. substances can be used,
The above examples are not intended to be limiting, and any substance that suppresses or eliminates the enzymatic activity of the reductase 5α-reductase may be used. The above-mentioned stabilized chlorine dioxide is an aqueous solution of chlorine dioxide that has been chemically stabilized, and is disclosed in, for example, US Patent No. 4.296.10.
3: No3.147.124: No, 3J23.521
No. 2.701.781. This stabilized chlorine dioxide contains a stabilizer such as caustic soda for the purpose of chemically stabilizing explosive chlorine dioxide. It is also known that this stabilized chlorine dioxide can be made non-toxic to the human body by changing its concentration or the combination of additives. These oxidizing agents have a composition and concentration that is sufficient to suppress or eliminate the action of 5α-reductase and do not affect the human body, and are applied to the bald scalp several times a day, along with other ingredients as necessary. Apply to the skin, apply a light pine surge, and use this continuously for a long period of time. As a result, various oxidizing substances penetrate into the sebaceous glands through the pores of the scalp, and the reduced coenzyme (NA) present in the sebaceous glands.
D kl , NAI) Attenuates or eliminates the activity of Pn(TPNH) and 5α-reductase enzymes. For this reason, the testosterone brought from Suimaru is rarely converted to IT, and testosterone or Shonan's 5α
The action of DHT alone acts on hair matrix cells. This 5
It has been reported that α-reductase is present only in the sebaceous glands, and only in the first and second stages. Therefore, testosterone is directly transported from Bimaru to the hair matrix through route a, forming 5αIJHT of small wrinkles and promoting the growth of hair.
The effects of the present invention are not impaired. This testosterone or small mouse 5αD1iT is. Similar to the development of beards and chest hair after puberty in men, it also has a positive effect on scalp hair, and as shown in the hair regeneration process diagram above, hair follicles are developed and formed, with active cells in the hair follicle. Fission occurs and the cow matures into hard hair. (Example) A clinical test was conducted on two types of stabilized chlorine dioxide (aqueous solution) and potassium bromate in the following manner. This clinical trial was conducted in the United States with 3 participants per test.
The test was conducted for 5 men aged 0-50,
I used it 3 times a day, about 5 hours apart. The feminized chlorine dioxide aqueous solution used in this test was a solution containing about 25% of sodium chlorite as a stabilizer and 4 to 5% of caustic soda. It was used at the specified concentration. The results are shown in the table below, and although the effects in Table 5 varied from user to user, overall. The judgment is made by integrating the above. NO9 drug Product name Chemical concentration Q after start of use
1 month later 3, same as above 250ppm Same as above 4, same as above 500ppm
Same as above 6 Same as above 89
6 Same as above 7, Same as above
12% Same as above) Effect after 3 months Terminal hair after 6 months and slight growth Terminal hair and progress of elongation
The above results of hair hardening and slight elongation confirmed the validity of the theory of the present invention. As mentioned above, the present invention is based on new research results on the process of hair development, and the conventional lateral hair growth and 11 hair preparations are simply based on factors such as the elegance of the bulb area and circulatory disorders. In contrast, the present invention inhibits and eliminates the action of the reductase 5α Ritotase present in the sebaceous glands, prevents the conversion to the powerful 5αDHT, and secondarily improves hair matrix cells. It removes the factors that suppress cell division in hair cells and promotes their division by allowing normal testosterone to act on hair matrix cells.It has an unprecedented effect on turning love hair in bald areas into terminal hair. We have it. 4. Brief explanation of the drawings Figure 1 is an explanatory diagram of the hair cycle on which the present invention is based. FIG. 2 is an explanatory diagram of the action pathway of the male hormone testosterone. In the figure, 1... sebaceous gland, 2... name, 3... hair follicle. 4... bulb part, 5... hair matrix cell, 7... dermal papilla,
8...Suimaru Figure 1

Claims (1)

[Claims] A hair growth and tonic agent characterized by containing a substance that suppresses or eliminates the action of 5α reductase, a reductase enzyme present in sebaceous glands.