JPS5817366A - 血液試料分離剤 - Google Patents
血液試料分離剤Info
- Publication number
- JPS5817366A JPS5817366A JP56115718A JP11571881A JPS5817366A JP S5817366 A JPS5817366 A JP S5817366A JP 56115718 A JP56115718 A JP 56115718A JP 11571881 A JP11571881 A JP 11571881A JP S5817366 A JPS5817366 A JP S5817366A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- serum
- viscosity
- polyether polyurethane
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 25
- 239000008280 blood Substances 0.000 title claims abstract description 25
- 238000000926 separation method Methods 0.000 title claims abstract description 15
- 229920002635 polyurethane Polymers 0.000 claims abstract description 30
- 239000004814 polyurethane Substances 0.000 claims abstract description 30
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 28
- 229920000570 polyether Polymers 0.000 claims description 28
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 26
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000945 filler Substances 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 abstract description 20
- 239000000203 mixture Substances 0.000 abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 16
- 230000004888 barrier function Effects 0.000 abstract description 13
- 210000000601 blood cell Anatomy 0.000 abstract description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 10
- 230000005484 gravity Effects 0.000 abstract description 9
- 230000002209 hydrophobic effect Effects 0.000 abstract description 8
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 5
- 229910002012 Aerosil® Inorganic materials 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 abstract description 3
- 238000005070 sampling Methods 0.000 abstract 2
- 239000004743 Polypropylene Substances 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 238000010241 blood sampling Methods 0.000 abstract 1
- 229920000728 polyester Polymers 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 16
- 238000005119 centrifugation Methods 0.000 description 9
- -1 polytetramethylene Polymers 0.000 description 8
- 239000000377 silicon dioxide Substances 0.000 description 7
- 125000005442 diisocyanate group Chemical group 0.000 description 6
- 239000005062 Polybutadiene Substances 0.000 description 5
- 230000002411 adverse Effects 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 229920002857 polybutadiene Polymers 0.000 description 5
- 229920001451 polypropylene glycol Polymers 0.000 description 5
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000004159 blood analysis Methods 0.000 description 3
- 239000012503 blood component Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009974 thixotropic effect Effects 0.000 description 2
- VNMOIBZLSJDQEO-UHFFFAOYSA-N 1,10-diisocyanatodecane Chemical compound O=C=NCCCCCCCCCCN=C=O VNMOIBZLSJDQEO-UHFFFAOYSA-N 0.000 description 1
- ZTNJGMFHJYGMDR-UHFFFAOYSA-N 1,2-diisocyanatoethane Chemical compound O=C=NCCN=C=O ZTNJGMFHJYGMDR-UHFFFAOYSA-N 0.000 description 1
- ZXHZWRZAWJVPIC-UHFFFAOYSA-N 1,2-diisocyanatonaphthalene Chemical compound C1=CC=CC2=C(N=C=O)C(N=C=O)=CC=C21 ZXHZWRZAWJVPIC-UHFFFAOYSA-N 0.000 description 1
- OVBFMUAFNIIQAL-UHFFFAOYSA-N 1,4-diisocyanatobutane Chemical compound O=C=NCCCCN=C=O OVBFMUAFNIIQAL-UHFFFAOYSA-N 0.000 description 1
- DFPJRUKWEPYFJT-UHFFFAOYSA-N 1,5-diisocyanatopentane Chemical compound O=C=NCCCCCN=C=O DFPJRUKWEPYFJT-UHFFFAOYSA-N 0.000 description 1
- QUPKOUOXSNGVLB-UHFFFAOYSA-N 1,8-diisocyanatooctane Chemical compound O=C=NCCCCCCCCN=C=O QUPKOUOXSNGVLB-UHFFFAOYSA-N 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000004847 absorption spectroscopy Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 229940107161 cholesterol Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- FSEUPUDHEBLWJY-HWKANZROSA-N diacetylmonoxime Chemical compound CC(=O)C(\C)=N\O FSEUPUDHEBLWJY-HWKANZROSA-N 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polyurethanes Or Polyureas (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56115718A JPS5817366A (ja) | 1981-07-22 | 1981-07-22 | 血液試料分離剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56115718A JPS5817366A (ja) | 1981-07-22 | 1981-07-22 | 血液試料分離剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5817366A true JPS5817366A (ja) | 1983-02-01 |
| JPH0131588B2 JPH0131588B2 (enExample) | 1989-06-27 |
Family
ID=14669430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56115718A Granted JPS5817366A (ja) | 1981-07-22 | 1981-07-22 | 血液試料分離剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5817366A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS602819A (ja) * | 1983-06-18 | 1985-01-09 | Babcock Hitachi Kk | フライアッシュ処理方法 |
| WO1997008548A1 (en) * | 1995-08-28 | 1997-03-06 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Composition for separating serum or plasma |
| WO2010053180A1 (ja) * | 2008-11-07 | 2010-05-14 | 日立化成工業株式会社 | 血清又は血漿分離材及びそれを用いた採血管 |
-
1981
- 1981-07-22 JP JP56115718A patent/JPS5817366A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS602819A (ja) * | 1983-06-18 | 1985-01-09 | Babcock Hitachi Kk | フライアッシュ処理方法 |
| WO1997008548A1 (en) * | 1995-08-28 | 1997-03-06 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Composition for separating serum or plasma |
| WO2010053180A1 (ja) * | 2008-11-07 | 2010-05-14 | 日立化成工業株式会社 | 血清又は血漿分離材及びそれを用いた採血管 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0131588B2 (enExample) | 1989-06-27 |
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