JPS58146580A - ベンゾチエニルアリルアミン類、その製法およびその医薬としての用途 - Google Patents

ベンゾチエニルアリルアミン類、その製法およびその医薬としての用途

Info

Publication number
JPS58146580A
JPS58146580A JP58016866A JP1686683A JPS58146580A JP S58146580 A JPS58146580 A JP S58146580A JP 58016866 A JP58016866 A JP 58016866A JP 1686683 A JP1686683 A JP 1686683A JP S58146580 A JPS58146580 A JP S58146580A
Authority
JP
Japan
Prior art keywords
compound
formula
thiophene
acid addition
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58016866A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0446275B2 (enExample
Inventor
アントン・ステユ−ツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of JPS58146580A publication Critical patent/JPS58146580A/ja
Publication of JPH0446275B2 publication Critical patent/JPH0446275B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Refuge Islands, Traffic Blockers, Or Guard Fence (AREA)
JP58016866A 1982-02-03 1983-02-02 ベンゾチエニルアリルアミン類、その製法およびその医薬としての用途 Granted JPS58146580A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH656/82-4 1982-02-03
CH656/82A CH653028A5 (de) 1982-02-03 1982-02-03 Benzthiophenallylamin-verbindungen und verfahren zu ihrer herstellung.

Publications (2)

Publication Number Publication Date
JPS58146580A true JPS58146580A (ja) 1983-09-01
JPH0446275B2 JPH0446275B2 (enExample) 1992-07-29

Family

ID=4192086

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58016866A Granted JPS58146580A (ja) 1982-02-03 1983-02-02 ベンゾチエニルアリルアミン類、その製法およびその医薬としての用途

Country Status (28)

Country Link
US (2) US4474141A (enExample)
JP (1) JPS58146580A (enExample)
AT (1) AT391865B (enExample)
AU (1) AU569838B2 (enExample)
BE (1) BE895751A (enExample)
CA (1) CA1193271A (enExample)
CH (1) CH653028A5 (enExample)
CY (1) CY1485A (enExample)
DE (1) DE3302814A1 (enExample)
DK (1) DK160043C (enExample)
ES (1) ES519477A0 (enExample)
FI (1) FI80689C (enExample)
FR (1) FR2520741B1 (enExample)
GB (1) GB2116171B (enExample)
HK (1) HK47789A (enExample)
HU (1) HU190886B (enExample)
IE (1) IE55073B1 (enExample)
IL (1) IL67813A0 (enExample)
IT (1) IT1197565B (enExample)
KE (1) KE3877A (enExample)
MY (1) MY8700167A (enExample)
NL (1) NL8300350A (enExample)
NZ (1) NZ203144A (enExample)
PH (1) PH22625A (enExample)
PT (1) PT76175B (enExample)
SE (1) SE455095B (enExample)
SG (1) SG16289G (enExample)
ZA (1) ZA83733B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007049813A1 (ja) * 2005-10-27 2007-05-03 Teijin Pharma Limited ベンゾ［ｂ］チオフェン誘導体およびその製造方法
JP2007119483A (ja) * 2001-02-22 2007-05-17 Teijin Ltd ベンゾ［ｂ］チオフェン誘導体、およびその製造方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672311A5 (enExample) * 1985-09-14 1989-11-15 Sandoz Ag
EP0404721A3 (de) * 1989-06-20 1991-12-27 Ciba-Geigy Ag Mikrobizide Mittel
AU634871B2 (en) * 1990-03-20 1993-03-04 Banyu Pharmaceutical Co., Ltd. Substituted amine derivatives having anti-hyperlipemia activity
FR2695930B1 (fr) * 1992-09-22 1994-12-23 Sanofi Elf Dérivé du 2-éthyl benzo[b]thiophène, son procédé de préparation et son utilisation comme intermédiaire de synthèse.
CN102898314B (zh) * 2012-11-13 2014-09-03 山东铂源药业有限公司 一种盐酸特比萘芬的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632440A (en) * 1979-08-22 1981-04-01 Sandoz Ag Propenylamines* their manufacture* pharmaceutic composition containing them and their use as medicine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250019B (enExample) * 1963-07-19
CH442353A (de) * 1964-04-16 1967-08-31 Sandoz Ag Verfahren zur Herstellung von neuen Benzothiophen-Derivaten
US3930537A (en) * 1974-05-06 1976-01-06 The United States Of America As Represented By The United States Energy Research And Development Administration Heat exchanger
EP0000896B1 (en) * 1977-08-19 1982-10-13 Sandoz Ag Propenyl amines, processes for their production and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632440A (en) * 1979-08-22 1981-04-01 Sandoz Ag Propenylamines* their manufacture* pharmaceutic composition containing them and their use as medicine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007119483A (ja) * 2001-02-22 2007-05-17 Teijin Ltd ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
WO2007049813A1 (ja) * 2005-10-27 2007-05-03 Teijin Pharma Limited ベンゾ［ｂ］チオフェン誘導体およびその製造方法

Also Published As

Publication number Publication date
CH653028A5 (de) 1985-12-13
FI830297A0 (fi) 1983-01-27
NZ203144A (en) 1985-12-13
AU1089783A (en) 1983-08-11
ZA83733B (en) 1984-09-26
DK40883D0 (da) 1983-02-01
BE895751A (fr) 1983-08-01
PH22625A (en) 1988-10-28
IT8347666A0 (it) 1983-02-03
IT8347666A1 (it) 1984-08-03
PT76175A (en) 1983-03-01
FI80689B (fi) 1990-03-30
KE3877A (en) 1989-07-21
US4474141A (en) 1984-10-02
GB2116171A (en) 1983-09-21
FR2520741A1 (fr) 1983-08-05
MY8700167A (en) 1987-12-31
DK160043C (da) 1991-06-17
AT391865B (de) 1990-12-10
GB8302573D0 (en) 1983-03-02
PT76175B (en) 1986-01-15
IT1197565B (it) 1988-12-06
DE3302814A1 (de) 1983-08-11
SG16289G (en) 1989-07-07
SE8300535D0 (sv) 1983-02-01
IE830202L (en) 1983-08-03
US4737516A (en) 1988-04-12
AU569838B2 (en) 1988-02-25
DE3302814C2 (enExample) 1992-06-25
HK47789A (en) 1989-06-23
DK40883A (da) 1983-08-04
IE55073B1 (en) 1990-05-23
GB2116171B (en) 1986-04-03
DK160043B (da) 1991-01-21
CA1193271A (en) 1985-09-10
JPH0446275B2 (enExample) 1992-07-29
IL67813A0 (en) 1983-06-15
NL8300350A (nl) 1983-09-01
FI80689C (fi) 1990-07-10
CY1485A (en) 1989-12-08
FI830297L (fi) 1983-08-04
ES8403473A1 (es) 1984-03-16
SE8300535L (sv) 1983-08-04
SE455095B (sv) 1988-06-20
ATA34983A (de) 1990-06-15
FR2520741B1 (fr) 1986-03-21
HU190886B (en) 1986-12-28
ES519477A0 (es) 1984-03-16

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