JPS58146508A - （１−シンナモイル又は１−フエネチルカルボニル）ピペラジン誘導体を含有する神経系用薬剤 - Google Patents

（１−シンナモイル又は１−フエネチルカルボニル）ピペラジン誘導体を含有する神経系用薬剤

Info

Publication number
JPS58146508A
JPS58146508A JP58016860A JP1686083A JPS58146508A JP S58146508 A JPS58146508 A JP S58146508A JP 58016860 A JP58016860 A JP 58016860A JP 1686083 A JP1686083 A JP 1686083A JP S58146508 A JPS58146508 A JP S58146508A
Authority
JP
Japan
Prior art keywords
group
drug
nervous system
cinnamoyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58016860A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0344051B2 (enExample
Inventor
アライン・プラテル
アライン・ラコ−
ギイ−・ブリユゲリ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Publication of JPS58146508A publication Critical patent/JPS58146508A/ja
Publication of JPH0344051B2 publication Critical patent/JPH0344051B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP58016860A 1982-02-04 1983-02-03 （１−シンナモイル又は１−フエネチルカルボニル）ピペラジン誘導体を含有する神経系用薬剤 Granted JPS58146508A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19457/82A IT1151104B (it) 1982-02-04 1982-02-04 Impiego terapeutico di derivati (1-cinnamoil oppure 1-fenetil-carbonil)piperazinici
IT19457A/82 1982-02-04

Publications (2)

Publication Number Publication Date
JPS58146508A true JPS58146508A (ja) 1983-09-01
JPH0344051B2 JPH0344051B2 (enExample) 1991-07-04

Family

ID=11158179

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58016860A Granted JPS58146508A (ja) 1982-02-04 1983-02-03 （１−シンナモイル又は１−フエネチルカルボニル）ピペラジン誘導体を含有する神経系用薬剤

Country Status (4)

Country Link
US (1) US4500531A (enExample)
JP (1) JPS58146508A (enExample)
FR (1) FR2520618A1 (enExample)
IT (1) IT1151104B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique
JPS6172773A (ja) * 1984-09-17 1986-04-14 Terumo Corp ピペラジン誘導体およびこれを含有する血管拡張剤
JP2787628B2 (ja) * 1992-01-21 1998-08-20 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
CA2514574A1 (en) * 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Use of sodium channel modulators for treating gastrointestinal tract disorders
CN101591310B (zh) * 2008-12-19 2012-03-21 王绍杰 一种马来酸桂哌齐特的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
FR2325372A2 (fr) * 1975-09-29 1977-04-22 Delalande Sa Nouveaux derives de la n-(trimethoxy-3,4,5 cinaamoyl) piperazine, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2520618A1 (fr) 1983-08-05
IT8219457A0 (it) 1982-02-04
IT1151104B (it) 1986-12-17
US4500531A (en) 1985-02-19
FR2520618B1 (enExample) 1984-10-26
JPH0344051B2 (enExample) 1991-07-04

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