JPS5799519A - Stable suppository and its preparation - Google Patents
Stable suppository and its preparationInfo
- Publication number
- JPS5799519A JPS5799519A JP17640080A JP17640080A JPS5799519A JP S5799519 A JPS5799519 A JP S5799519A JP 17640080 A JP17640080 A JP 17640080A JP 17640080 A JP17640080 A JP 17640080A JP S5799519 A JPS5799519 A JP S5799519A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- suppository
- drug
- oil
- drug action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a suppository having excellent storage stability and stable drug action and containing two drug components which cause lowering of the drug action by compounding, by dispersing one of the components in oil or fat having specific water-content, and then mixing the dispersion with the other drug component and a substrate.
CONSTITUTION: In the preparation of a suppository containing the A agent such as cloxacillin, oxacillin, cephalexin, etc. and the B agent such as a β-lactam antibiotic substance having α-amino group (e.g. ampicillin, amoxicillin, etc.) which causes lowering of the drug action by compounding, the A agent is dispersed uniformly in an oil or fat having a water-content of ≤0.2wt% (e.g. olive oil, beef tallow, etc.), a substrate composed of a 12W18C saturated fatty acid triglyceride containing monoglyceride and diglyceride is molten by heating and added to the above dispersion, the B agent is uniformly dispersed in the mixture, and the composition is formed to a suppository having a proper shape. The ratio of the A agent to the B agent is pref. 1 to 0.5W2, and the both agents are pref. pulverized to about 30W50μ diameter before mixing.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17640080A JPS5799519A (en) | 1980-12-12 | 1980-12-12 | Stable suppository and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17640080A JPS5799519A (en) | 1980-12-12 | 1980-12-12 | Stable suppository and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5799519A true JPS5799519A (en) | 1982-06-21 |
Family
ID=16013002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17640080A Pending JPS5799519A (en) | 1980-12-12 | 1980-12-12 | Stable suppository and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5799519A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4525339A (en) * | 1982-10-15 | 1985-06-25 | Hoffmann-La Roche Inc. | Enteric coated oral dosage form |
-
1980
- 1980-12-12 JP JP17640080A patent/JPS5799519A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4525339A (en) * | 1982-10-15 | 1985-06-25 | Hoffmann-La Roche Inc. | Enteric coated oral dosage form |
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