JPS5799519A - Stable suppository and its preparation - Google Patents

Stable suppository and its preparation

Info

Publication number
JPS5799519A
JPS5799519A JP17640080A JP17640080A JPS5799519A JP S5799519 A JPS5799519 A JP S5799519A JP 17640080 A JP17640080 A JP 17640080A JP 17640080 A JP17640080 A JP 17640080A JP S5799519 A JPS5799519 A JP S5799519A
Authority
JP
Japan
Prior art keywords
agent
suppository
drug
oil
drug action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17640080A
Other languages
Japanese (ja)
Inventor
Yukio Sumita
Masaki Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP17640080A priority Critical patent/JPS5799519A/en
Publication of JPS5799519A publication Critical patent/JPS5799519A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a suppository having excellent storage stability and stable drug action and containing two drug components which cause lowering of the drug action by compounding, by dispersing one of the components in oil or fat having specific water-content, and then mixing the dispersion with the other drug component and a substrate.
CONSTITUTION: In the preparation of a suppository containing the A agent such as cloxacillin, oxacillin, cephalexin, etc. and the B agent such as a β-lactam antibiotic substance having α-amino group (e.g. ampicillin, amoxicillin, etc.) which causes lowering of the drug action by compounding, the A agent is dispersed uniformly in an oil or fat having a water-content of ≤0.2wt% (e.g. olive oil, beef tallow, etc.), a substrate composed of a 12W18C saturated fatty acid triglyceride containing monoglyceride and diglyceride is molten by heating and added to the above dispersion, the B agent is uniformly dispersed in the mixture, and the composition is formed to a suppository having a proper shape. The ratio of the A agent to the B agent is pref. 1 to 0.5W2, and the both agents are pref. pulverized to about 30W50μ diameter before mixing.
COPYRIGHT: (C)1982,JPO&Japio
JP17640080A 1980-12-12 1980-12-12 Stable suppository and its preparation Pending JPS5799519A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17640080A JPS5799519A (en) 1980-12-12 1980-12-12 Stable suppository and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17640080A JPS5799519A (en) 1980-12-12 1980-12-12 Stable suppository and its preparation

Publications (1)

Publication Number Publication Date
JPS5799519A true JPS5799519A (en) 1982-06-21

Family

ID=16013002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17640080A Pending JPS5799519A (en) 1980-12-12 1980-12-12 Stable suppository and its preparation

Country Status (1)

Country Link
JP (1) JPS5799519A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form

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