JPS5795980A - 7-hydroxy pgi2 and its preparation - Google Patents
7-hydroxy pgi2 and its preparationInfo
- Publication number
- JPS5795980A JPS5795980A JP55172543A JP17254380A JPS5795980A JP S5795980 A JPS5795980 A JP S5795980A JP 55172543 A JP55172543 A JP 55172543A JP 17254380 A JP17254380 A JP 17254380A JP S5795980 A JPS5795980 A JP S5795980A
- Authority
- JP
- Japan
- Prior art keywords
- configuration
- compound
- pgi
- hydroxy
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101100391618 Arabidopsis thaliana PGI1 gene Proteins 0.000 title 1
- 101150095588 pgi2 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical class [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55172543A JPS5795980A (en) | 1980-12-09 | 1980-12-09 | 7-hydroxy pgi2 and its preparation |
DE8181110156T DE3176313D1 (en) | 1980-12-09 | 1981-12-04 | Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof |
US06/327,741 US4472428A (en) | 1980-12-09 | 1981-12-04 | Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore |
EP81110156A EP0054795B1 (en) | 1980-12-09 | 1981-12-04 | Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55172543A JPS5795980A (en) | 1980-12-09 | 1980-12-09 | 7-hydroxy pgi2 and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5795980A true JPS5795980A (en) | 1982-06-15 |
JPH026755B2 JPH026755B2 (enrdf_load_stackoverflow) | 1990-02-13 |
Family
ID=15943829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55172543A Granted JPS5795980A (en) | 1980-12-09 | 1980-12-09 | 7-hydroxy pgi2 and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5795980A (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112979600A (zh) * | 2021-03-01 | 2021-06-18 | 厦门大学 | 裂环酰基间苯三酚类化合物及其在制备抗癌药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55121210A (en) * | 1979-03-13 | 1980-09-18 | Matsushita Electric Ind Co Ltd | Nonncombustible inorganic coating material for electronic part |
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
-
1980
- 1980-12-09 JP JP55172543A patent/JPS5795980A/ja active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55121210A (en) * | 1979-03-13 | 1980-09-18 | Matsushita Electric Ind Co Ltd | Nonncombustible inorganic coating material for electronic part |
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112979600A (zh) * | 2021-03-01 | 2021-06-18 | 厦门大学 | 裂环酰基间苯三酚类化合物及其在制备抗癌药物中的应用 |
Also Published As
Publication number | Publication date |
---|---|
JPH026755B2 (enrdf_load_stackoverflow) | 1990-02-13 |
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