JPS5767578A - N-phthtalidy-5-fluorouracil derivative - Google Patents

N-phthtalidy-5-fluorouracil derivative

Info

Publication number
JPS5767578A
JPS5767578A JP55140509A JP14050980A JPS5767578A JP S5767578 A JPS5767578 A JP S5767578A JP 55140509 A JP55140509 A JP 55140509A JP 14050980 A JP14050980 A JP 14050980A JP S5767578 A JPS5767578 A JP S5767578A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
phthtalidy
phthalidyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55140509A
Other languages
English (en)
Other versions
JPS6348273B2 (ja
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Kikuo Wakizaka
Keiko Ichikawa
Kikuo Nakazato
Taiji Okada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP55140509A priority Critical patent/JPS5767578A/ja
Priority to US06/385,379 priority patent/US4528372A/en
Priority to AT81902732T priority patent/ATE13764T1/de
Priority to AU76411/81A priority patent/AU543835B2/en
Priority to PCT/JP1981/000260 priority patent/WO1982001370A1/ja
Priority to EP81902732A priority patent/EP0062068B1/en
Priority to DE8181902732T priority patent/DE3170942D1/de
Priority to BR8108842A priority patent/BR8108842A/pt
Publication of JPS5767578A publication Critical patent/JPS5767578A/ja
Priority to DK256982A priority patent/DK151630B/da
Priority to SU3451505A priority patent/SU1258325A3/ru
Publication of JPS6348273B2 publication Critical patent/JPS6348273B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thin Film Transistor (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP55140509A 1980-10-09 1980-10-09 N-phthtalidy-5-fluorouracil derivative Granted JPS5767578A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP55140509A JPS5767578A (en) 1980-10-09 1980-10-09 N-phthtalidy-5-fluorouracil derivative
EP81902732A EP0062068B1 (en) 1980-10-09 1981-09-30 N-phthalidyl-5-fluorouracil derivatives
AT81902732T ATE13764T1 (de) 1980-10-09 1981-09-30 N-phthalidyl-5-fluor-uracil-abkoemmlinge.
AU76411/81A AU543835B2 (en) 1980-10-09 1981-09-30 N-phthalidyl-5-fluorouracil derivatives
PCT/JP1981/000260 WO1982001370A1 (en) 1980-10-09 1981-09-30 N-phthalidyl-5-fluorouracil derivatives
US06/385,379 US4528372A (en) 1980-10-09 1981-09-30 N-Phthalidyl-5-fluorouracils
DE8181902732T DE3170942D1 (en) 1980-10-09 1981-09-30 N-phthalidyl-5-fluorouracil derivatives
BR8108842A BR8108842A (pt) 1980-10-09 1981-09-30 Derivados da n-ftalidil-5-fluoruracila
DK256982A DK151630B (da) 1980-10-09 1982-06-08 Analogifremgangsmaade til fremstilling af n-phthalidyl-5-fluoruracilderivater
SU3451505A SU1258325A3 (ru) 1980-10-09 1982-06-08 Способ получени производных @ -фталидил-5-фторурацила

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55140509A JPS5767578A (en) 1980-10-09 1980-10-09 N-phthtalidy-5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
JPS5767578A true JPS5767578A (en) 1982-04-24
JPS6348273B2 JPS6348273B2 (ja) 1988-09-28

Family

ID=15270296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55140509A Granted JPS5767578A (en) 1980-10-09 1980-10-09 N-phthtalidy-5-fluorouracil derivative

Country Status (10)

Country Link
US (1) US4528372A (ja)
EP (1) EP0062068B1 (ja)
JP (1) JPS5767578A (ja)
AT (1) ATE13764T1 (ja)
AU (1) AU543835B2 (ja)
BR (1) BR8108842A (ja)
DE (1) DE3170942D1 (ja)
DK (1) DK151630B (ja)
SU (1) SU1258325A3 (ja)
WO (1) WO1982001370A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993075A (ja) * 1982-11-18 1984-05-29 Shionogi & Co Ltd １−フタリジル−５−フルオロウラシル誘導体の製造法
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
WO2018080161A1 (ko) * 2016-10-25 2018-05-03 경북대학교 산학협력단 항병원성 활성 및 바이오필름 형성 억제 효과를 나타내는 화합물의 신규한 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5716881A (en) * 1980-07-04 1982-01-28 Shionogi & Co Ltd 5-fluorouracil derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997481A (en) * 1958-09-02 1961-08-22 Dow Chemical Co Phthalides
JPS5324952B2 (ja) * 1973-11-28 1978-07-24
GB1518391A (en) * 1976-01-07 1978-07-19 Taiho Pharmaceutical Co Ltd Anti-tumour composition
US4196202A (en) * 1977-12-20 1980-04-01 Taiji Okada Carcinostatic composition containing 3-N-o-toluyl-5-fluorouracil producing the same
JPS5732270A (en) * 1980-08-05 1982-02-20 Shionogi & Co Ltd Preparation of 3-substituted-5-halogenated uracil
JPS5732271A (en) * 1980-08-05 1982-02-20 Shionogi & Co Ltd Preparation of 1-substituted-5-halogenated uracil

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5716881A (en) * 1980-07-04 1982-01-28 Shionogi & Co Ltd 5-fluorouracil derivative

Also Published As

Publication number Publication date
DE3170942D1 (en) 1985-07-18
BR8108842A (pt) 1982-09-21
EP0062068A4 (en) 1983-02-09
US4528372A (en) 1985-07-09
AU543835B2 (en) 1985-05-02
DK256982A (da) 1982-06-08
DK151630B (da) 1987-12-21
EP0062068B1 (en) 1985-06-12
AU7641181A (en) 1982-05-11
ATE13764T1 (de) 1985-06-15
JPS6348273B2 (ja) 1988-09-28
SU1258325A3 (ru) 1986-09-15
WO1982001370A1 (en) 1982-04-29
EP0062068A1 (en) 1982-10-13

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