JPS5759893A - 4,1-benzoxazepin derivative - Google Patents

4,1-benzoxazepin derivative

Info

Publication number
JPS5759893A
JPS5759893A JP55136646A JP13664680A JPS5759893A JP S5759893 A JPS5759893 A JP S5759893A JP 55136646 A JP55136646 A JP 55136646A JP 13664680 A JP13664680 A JP 13664680A JP S5759893 A JPS5759893 A JP S5759893A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
benzoxazepin
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55136646A
Other languages
Japanese (ja)
Other versions
JPH029593B2 (en
Inventor
Kentaro Hirai
Shigeru Matsutani
Teruyuki Ishiha
Itsuo Makino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP55136646A priority Critical patent/JPS5759893A/en
Priority to US06/250,299 priority patent/US4374842A/en
Priority to CH253081A priority patent/CH645637A5/en
Priority to AU69623/81A priority patent/AU544637B2/en
Priority to DE19813115552 priority patent/DE3115552A1/en
Priority to FR8107700A priority patent/FR2480751A1/en
Priority to IT67533/81A priority patent/IT1146746B/en
Priority to GB8112387A priority patent/GB2075012B/en
Publication of JPS5759893A publication Critical patent/JPS5759893A/en
Priority to US06/397,855 priority patent/US4476133A/en
Publication of JPH029593B2 publication Critical patent/JPH029593B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI[R' is H, halogen, nitro; R2 is H, halogen, trifluoromethyl; -A-B- is formula IV W formula VI (R3 is alkyl, dialkylaminoalkyl; R4 is alkyl, alkylthio)]and its pharmaceutically permissible acid adduct.
EXAMPLE: 8-Chloro-6-(2-chlorophenyl)-1-oxo-1H,4H,6H-[1,2,4]oxadiazolo[4,3-a] [4,1]benzoxazepin.
USE: Psycotropic such as antianxiety agent, tranquilizer, anticonvulsant, hypnotic.
PREPARATION: A compound of formula II reacts with hydroxylamine in an inert solvent to form an oxime of formula III, which is made to react with an alkyl halocarbonate such as methyl chlorocarbonate in the presence of a hase such as triethylamine to give the compound of formula Ia where -A-B- is formula IV in formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP55136646A 1980-04-18 1980-09-29 4,1-benzoxazepin derivative Granted JPS5759893A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP55136646A JPS5759893A (en) 1980-09-29 1980-09-29 4,1-benzoxazepin derivative
US06/250,299 US4374842A (en) 1980-04-18 1981-04-02 4,1-Benzoxazepines and compositions
CH253081A CH645637A5 (en) 1980-04-18 1981-04-15 4,1-BENZOXAZEPINE.
FR8107700A FR2480751A1 (en) 1980-04-18 1981-04-16 4,1-BENZOXAZEPINES AND THEIR USE AS PHARMACEUTICAL PRODUCTS FOR THE CENTRAL NERVOUS SYSTEM
DE19813115552 DE3115552A1 (en) 1980-04-18 1981-04-16 4.1-BENZOXAZEPINE AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
AU69623/81A AU544637B2 (en) 1980-04-18 1981-04-16 4,1-benzoxazepines
IT67533/81A IT1146746B (en) 1980-04-18 1981-04-17 COMPOUND OF THE CATEGORY OF BENZOSSAZEPIN USABLE AS AN ACTIVE DRUG ON THE CENTRAL NERVOUS SYSTEM
GB8112387A GB2075012B (en) 1980-04-18 1981-04-21 4,1-benzoxazepines
US06/397,855 US4476133A (en) 1980-04-18 1982-07-13 Triazolo-4,1-benzoxazepines having CNS activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55136646A JPS5759893A (en) 1980-09-29 1980-09-29 4,1-benzoxazepin derivative

Publications (2)

Publication Number Publication Date
JPS5759893A true JPS5759893A (en) 1982-04-10
JPH029593B2 JPH029593B2 (en) 1990-03-02

Family

ID=15180178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55136646A Granted JPS5759893A (en) 1980-04-18 1980-09-29 4,1-benzoxazepin derivative

Country Status (1)

Country Link
JP (1) JPS5759893A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine

Also Published As

Publication number Publication date
JPH029593B2 (en) 1990-03-02

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