JPS5566593A - Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same - Google Patents

Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same

Info

Publication number
JPS5566593A
JPS5566593A JP13879278A JP13879278A JPS5566593A JP S5566593 A JPS5566593 A JP S5566593A JP 13879278 A JP13879278 A JP 13879278A JP 13879278 A JP13879278 A JP 13879278A JP S5566593 A JPS5566593 A JP S5566593A
Authority
JP
Japan
Prior art keywords
pyrimidine
compound
thiazolo
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13879278A
Other languages
Japanese (ja)
Other versions
JPS6233238B2 (en
Inventor
Takeo Oba
Kiyoshi Sakauchi
Toshio Tanaka
Kenzo Watanabe
Tatsuyuki Naritomo
Keiji Komoriya
Seiji Kurozumi
Kenji Hoshina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP13879278A priority Critical patent/JPS5566593A/en
Publication of JPS5566593A publication Critical patent/JPS5566593A/en
Publication of JPS6233238B2 publication Critical patent/JPS6233238B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I (R1 is phenyl, aralkyl or cycloaliphatic group; R2 is lower alkyl).
EXAMPLE: 5H-2, 3-Dihydro-7-methoxy-5-oxo-6-pheynlthiazolo[ 3, 2-a ]pyrimidine-1- oxide.
USE: Blood platelet coagulation inhibiting agent effective to arteriothrombosis, and also having antiphlogistic, antipyretic and analgesic activities.
PROCESS: The compound I is prepared by oxidizing 1 equivalent of a 7-alkoxythiazolo[3,2-a]pyrimidine derivative II with 0.5W3 equivlents of an oxidizing agent (e.g. a compound which selectively oxidizes the sulfide bond, such as peracetic acid), in an inert solvent such as acetic acid, at -78W+50°C, pref. -20W+30°C.
COPYRIGHT: (C)1980,JPO&Japio
JP13879278A 1978-11-13 1978-11-13 Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same Granted JPS5566593A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13879278A JPS5566593A (en) 1978-11-13 1978-11-13 Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13879278A JPS5566593A (en) 1978-11-13 1978-11-13 Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same

Publications (2)

Publication Number Publication Date
JPS5566593A true JPS5566593A (en) 1980-05-20
JPS6233238B2 JPS6233238B2 (en) 1987-07-20

Family

ID=15230316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13879278A Granted JPS5566593A (en) 1978-11-13 1978-11-13 Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same

Country Status (1)

Country Link
JP (1) JPS5566593A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049902A2 (en) * 1980-10-15 1982-04-21 Teijin Limited Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049902A2 (en) * 1980-10-15 1982-04-21 Teijin Limited Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof
EP0049902A3 (en) * 1980-10-15 1982-09-01 Teijin Limited Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof
US4421914A (en) * 1980-10-15 1983-12-20 Teijin Limited Thiazolo[3,2-a]pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
JPS6233238B2 (en) 1987-07-20

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