JPS5566593A - Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same - Google Patents
Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the sameInfo
- Publication number
- JPS5566593A JPS5566593A JP13879278A JP13879278A JPS5566593A JP S5566593 A JPS5566593 A JP S5566593A JP 13879278 A JP13879278 A JP 13879278A JP 13879278 A JP13879278 A JP 13879278A JP S5566593 A JPS5566593 A JP S5566593A
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidine
- compound
- thiazolo
- preparation
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound of formula I (R1 is phenyl, aralkyl or cycloaliphatic group; R2 is lower alkyl).
EXAMPLE: 5H-2, 3-Dihydro-7-methoxy-5-oxo-6-pheynlthiazolo[ 3, 2-a ]pyrimidine-1- oxide.
USE: Blood platelet coagulation inhibiting agent effective to arteriothrombosis, and also having antiphlogistic, antipyretic and analgesic activities.
PROCESS: The compound I is prepared by oxidizing 1 equivalent of a 7-alkoxythiazolo[3,2-a]pyrimidine derivative II with 0.5W3 equivlents of an oxidizing agent (e.g. a compound which selectively oxidizes the sulfide bond, such as peracetic acid), in an inert solvent such as acetic acid, at -78W+50°C, pref. -20W+30°C.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13879278A JPS5566593A (en) | 1978-11-13 | 1978-11-13 | Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13879278A JPS5566593A (en) | 1978-11-13 | 1978-11-13 | Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5566593A true JPS5566593A (en) | 1980-05-20 |
JPS6233238B2 JPS6233238B2 (en) | 1987-07-20 |
Family
ID=15230316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13879278A Granted JPS5566593A (en) | 1978-11-13 | 1978-11-13 | Thiazolo 3,2-a pyrimidine-1-oxide derivative, its preparation, and drug containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5566593A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0049902A2 (en) * | 1980-10-15 | 1982-04-21 | Teijin Limited | Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof |
-
1978
- 1978-11-13 JP JP13879278A patent/JPS5566593A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0049902A2 (en) * | 1980-10-15 | 1982-04-21 | Teijin Limited | Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof |
EP0049902A3 (en) * | 1980-10-15 | 1982-09-01 | Teijin Limited | Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof |
US4421914A (en) * | 1980-10-15 | 1983-12-20 | Teijin Limited | Thiazolo[3,2-a]pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6233238B2 (en) | 1987-07-20 |
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