JPS5759812A - Synergistic blend of (r,s)alpha- fluoromethylhistidine and cimetidine as antiulcer - Google Patents

Synergistic blend of (r,s)alpha- fluoromethylhistidine and cimetidine as antiulcer

Info

Publication number
JPS5759812A
JPS5759812A JP56128291A JP12829181A JPS5759812A JP S5759812 A JPS5759812 A JP S5759812A JP 56128291 A JP56128291 A JP 56128291A JP 12829181 A JP12829181 A JP 12829181A JP S5759812 A JPS5759812 A JP S5759812A
Authority
JP
Japan
Prior art keywords
fluoromethylhistidine
antiulcer
cimetidine
alpha
synergistic blend
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56128291A
Other languages
English (en)
Other versions
JPH0154326B2 (ja
Inventor
Koronitsushiyu Jiyanosu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5759812A publication Critical patent/JPS5759812A/ja
Publication of JPH0154326B2 publication Critical patent/JPH0154326B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP56128291A 1980-08-18 1981-08-18 Synergistic blend of (r,s)alpha- fluoromethylhistidine and cimetidine as antiulcer Granted JPS5759812A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17935880A 1980-08-18 1980-08-18

Publications (2)

Publication Number Publication Date
JPS5759812A true JPS5759812A (en) 1982-04-10
JPH0154326B2 JPH0154326B2 (ja) 1989-11-17

Family

ID=22656255

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56128291A Granted JPS5759812A (en) 1980-08-18 1981-08-18 Synergistic blend of (r,s)alpha- fluoromethylhistidine and cimetidine as antiulcer

Country Status (8)

Country Link
EP (1) EP0046290B1 (ja)
JP (1) JPS5759812A (ja)
AU (1) AU7398381A (ja)
DD (1) DD200404A5 (ja)
DE (1) DE3168036D1 (ja)
FI (1) FI812469L (ja)
GR (1) GR74627B (ja)
PT (1) PT73517B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06100446A (ja) * 1990-10-15 1994-04-12 Merck & Co Inc （Ｓ）−α−フルオロメチル−ヒスチジン及びそのエステルを使用するぜん息の治療方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447443A (en) * 1982-11-15 1984-05-08 Merck & Co., Inc. Anti-inflammatory/analgesic combination of α-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
FR2822709B1 (fr) * 2001-03-30 2007-01-19 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
FR2896156A1 (fr) * 2006-01-17 2007-07-20 Gaetan Terrasse Nouvelle utilisation de la tritoqualine en association avec des substances medicamenteuses antagonistes du recepteur h2 a l'histamine,pour le traitement des maladies inflammatoires digestives
EP2170317A4 (en) * 2007-02-12 2011-03-23 Mike Nicolaou TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD), GASTRO-OESOPHAGEAL REFLUX DISEASE (GERD), FOOD ALLERGIES, AND OTHER DISEASES AND GASTROINTESTIN DISORDERS AFFECTED BY APPROPRIATE MANAGEMENT OF HISTAMINE USING A COMBINATION OF INHIBITORS HISTIDINE DECARBOXYLASE, MEDICAMEN

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000302A (en) * 1972-04-20 1976-12-28 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
US4215221A (en) * 1977-06-01 1980-07-29 Merck & Co., Inc. Fluorination process

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06100446A (ja) * 1990-10-15 1994-04-12 Merck & Co Inc （Ｓ）−α−フルオロメチル−ヒスチジン及びそのエステルを使用するぜん息の治療方法

Also Published As

Publication number Publication date
JPH0154326B2 (ja) 1989-11-17
PT73517B (en) 1983-07-06
AU7398381A (en) 1982-02-25
EP0046290A1 (en) 1982-02-24
PT73517A (en) 1981-09-01
EP0046290B1 (en) 1985-01-02
GR74627B (ja) 1984-06-29
FI812469L (fi) 1982-02-19
DE3168036D1 (en) 1985-02-14
DD200404A5 (de) 1983-05-04

Similar Documents

Publication Publication Date Title
DE3369517D1 (en) Didehydromilbemycin derivatives, their preparation and compositions containing them
GB2074436B (en) Cereal snackfoods and compositions and methods for making the same
DE3176517D1 (en) Beta-lactam compounds, their preparation and use
PH17881A (en) Benzamides,compositions and agricultural method
DE3174472D1 (en) Cephalosporin derivatives, their preparation and compositions containing them
PH17937A (en) Imidazole derivatives,their compositions and use thereof
DE3166569D1 (en) Imidazole derivatives, their preparation and compositions containing them
IL69749A0 (en) Termiticidal hydroxyalkene derivatives,compositions containing them and methods of use therefor
IL62602A0 (en) Pyridoxine derivatives,their preparation and pharmaceutcal compositions containing them
IL68910A0 (en) Bis-triazole derivatives,their preparation and their use as fungicides
ZA832927B (en) Benzoazacycloalkyl-spiro-imidazolidines,their preparation and compositions containing them
JPS5759812A (en) Synergistic blend of (r,s)alpha- fluoromethylhistidine and cimetidine as antiulcer
IL68118A0 (en) Phenoxypropyltriazolyl-ketones and-carbinols,their preparation and their use as fungicides
AU1982983A (en) Pyridyl-pyrimidone derivatives and their use as histamine h1-antagonists
JPS56145224A (en) Pharmaceutical blend
IL62416A (en) 2-butoxy-6-ethyl-2-chloroacetanilides,and herbicidal methods and compositions comprising them
IL63061A (en) 6-arylhydrazono-pyrido(2,1-b)quinazoline-11-ones and their preparation
JPS5777650A (en) N-oxyamides, manufacture and use as fungicide
IL64212A0 (en) Pyrazole-substituted oximino-cyano-acetamide derivatives,their preparation and their use as fungicides
NZ209075A (en) 4-piperidinomethyl-1,3-dioxolane derivatives and pesticidal compositions
JPS5788054A (en) Humidity-proofing, ant-proofing and fungus- proofing mixture
ZA826024B (en) Carbapenem derivatives,their preparation and compositions containing them
IL62412A (en) 2-chloroacetanilides,herbicidal methods and compositions comprising them
IL72323A0 (en) 1h-azole-1-ethanol derivatives,their preparation and fungicidal compositions containing them
IL69008A0 (en) Azole-substituted oximino-cyanoacetamide derivatives,their preparation and their use as fungicides