DE3168036D1 - Synergistic combination of (r,s)alpha-fluoromethylhistidine and cimetidine as an anti-ulcer agent - Google Patents

Synergistic combination of (r,s)alpha-fluoromethylhistidine and cimetidine as an anti-ulcer agent

Info

Publication number
DE3168036D1
DE3168036D1 DE8181106371T DE3168036T DE3168036D1 DE 3168036 D1 DE3168036 D1 DE 3168036D1 DE 8181106371 T DE8181106371 T DE 8181106371T DE 3168036 T DE3168036 T DE 3168036T DE 3168036 D1 DE3168036 D1 DE 3168036D1
Authority
DE
Germany
Prior art keywords
fluoromethylhistidine
cimetidine
alpha
synergistic combination
ulcer agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181106371T
Other languages
English (en)
Inventor
Janos Kollonitsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3168036D1 publication Critical patent/DE3168036D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8181106371T 1980-08-18 1981-08-17 Synergistic combination of (r,s)alpha-fluoromethylhistidine and cimetidine as an anti-ulcer agent Expired DE3168036D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17935880A 1980-08-18 1980-08-18

Publications (1)

Publication Number Publication Date
DE3168036D1 true DE3168036D1 (en) 1985-02-14

Family

ID=22656255

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181106371T Expired DE3168036D1 (en) 1980-08-18 1981-08-17 Synergistic combination of (r,s)alpha-fluoromethylhistidine and cimetidine as an anti-ulcer agent

Country Status (8)

Country Link
EP (1) EP0046290B1 (de)
JP (1) JPS5759812A (de)
AU (1) AU7398381A (de)
DD (1) DD200404A5 (de)
DE (1) DE3168036D1 (de)
FI (1) FI812469L (de)
GR (1) GR74627B (de)
PT (1) PT73517B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447443A (en) * 1982-11-15 1984-05-08 Merck & Co., Inc. Anti-inflammatory/analgesic combination of α-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
US5030645A (en) * 1990-10-15 1991-07-09 Merck & Co., Inc. Method of treating asthma using (S)-α-fluoromethyl-histidine and esters thereof
FR2822709B1 (fr) * 2001-03-30 2007-01-19 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
FR2896156A1 (fr) * 2006-01-17 2007-07-20 Gaetan Terrasse Nouvelle utilisation de la tritoqualine en association avec des substances medicamenteuses antagonistes du recepteur h2 a l'histamine,pour le traitement des maladies inflammatoires digestives
EP2170317A4 (de) * 2007-02-12 2011-03-23 Mike Nicolaou Behandlung von copd, gastroösophagealer reflux-krankheit (gerd), lebensmittelallergien und anderen gastrointestinalen erkrankungen und störungen, die durch richtiges histamin-management gelindert werden, mit einer kombination von histidindecarboxylase-hemmern, lra-arzneimitteln und/oder anti-h2-arzneimitteln

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000302A (en) * 1972-04-20 1976-12-28 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
US4215221A (en) * 1977-06-01 1980-07-29 Merck & Co., Inc. Fluorination process

Also Published As

Publication number Publication date
PT73517A (en) 1981-09-01
JPS5759812A (en) 1982-04-10
DD200404A5 (de) 1983-05-04
GR74627B (de) 1984-06-29
FI812469L (fi) 1982-02-19
AU7398381A (en) 1982-02-25
JPH0154326B2 (de) 1989-11-17
EP0046290B1 (de) 1985-01-02
PT73517B (en) 1983-07-06
EP0046290A1 (de) 1982-02-24

Similar Documents

Publication Publication Date Title
NZ206562A (en) 1-azolyl-2-aryl-3-fluoroalkan-2-ol derivatives and fungicidal compositions
IL63839A0 (en) N-arylbenzamides,herbicidal compositions containing them and method of using them
PH17937A (en) Imidazole derivatives,their compositions and use thereof
DE3176517D1 (en) Beta-lactam compounds, their preparation and use
IL69749A0 (en) Termiticidal hydroxyalkene derivatives,compositions containing them and methods of use therefor
DE3166569D1 (en) Imidazole derivatives, their preparation and compositions containing them
JPS56109557A (en) Antiibacterial agent
PH16354A (en) Two-functional-group-containing terpenoids,processes for the preparation of the same,and anti-ulcer agents containing the same
DE3275729D1 (en) The preservation of wood
JPS5795971A (en) Compound, manufacture and use
NZ195925A (en) Triazolylphenacyl pyridyl ether derivatives and fungicidal compositions
AU543270B2 (en) Synergistic combination of fungicides
DE3168036D1 (en) Synergistic combination of (r,s)alpha-fluoromethylhistidine and cimetidine as an anti-ulcer agent
AU544262B2 (en) Fluorinated pentene diamine derivatives
JPS5795973A (en) Compound, manufacture and use
JPS5729676A (en) Fixation agent
GB2079285B (en) Dipthosphonate derivatives and pahrmaceutical compositions containing them
PH19132A (en) Cycloalkane derivatives and compositions containing the same
IL62416A (en) 2-butoxy-6-ethyl-2-chloroacetanilides,and herbicidal methods and compositions comprising them
NZ196548A (en) 2-haloacetanilide derivatives and herbicidal compositions
JPS5785362A (en) Cyclic acylaminoperfluoroalkane sulfonanilide and derivatives
JPS5774362A (en) Anthraquinone-azo compound, manufacture and use
JPS5777650A (en) N-oxyamides, manufacture and use as fungicide
NZ195927A (en) Azolyl-silyl-glycol ethers and fungicidal compositions
NZ195983A (en) Benzeneamine derivatives and veterinary and fungicidal compositions

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee