JPS5756464A - Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 - Google Patents
Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2Info
- Publication number
- JPS5756464A JPS5756464A JP55130643A JP13064380A JPS5756464A JP S5756464 A JPS5756464 A JP S5756464A JP 55130643 A JP55130643 A JP 55130643A JP 13064380 A JP13064380 A JP 13064380A JP S5756464 A JPS5756464 A JP S5756464A
- Authority
- JP
- Japan
- Prior art keywords
- thromboxane
- inhibitor
- halogen
- compound shown
- biosyntesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DLICNNKFLLTGEG-UHFFFAOYSA-N 8-imidazol-1-yl-2-phenyloctanoic acid;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C(=O)O)CCCCCCN1C=CN=C1 DLICNNKFLLTGEG-UHFFFAOYSA-N 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55130643A JPS5756464A (en) | 1980-09-22 | 1980-09-22 | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
| GB8128515A GB2084150B (en) | 1980-09-22 | 1981-09-21 | Imidazole derivatives |
| DE19813137674 DE3137674A1 (de) | 1980-09-22 | 1981-09-22 | Imidazolderivate und pharmazeutische mittel, welche diese derivate enthalten |
| US06/304,531 US4346099A (en) | 1980-09-22 | 1981-09-22 | Carboxy-imidazole derivatives, compositions and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55130643A JPS5756464A (en) | 1980-09-22 | 1980-09-22 | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5756464A true JPS5756464A (en) | 1982-04-05 |
| JPS622586B2 JPS622586B2 (cs) | 1987-01-20 |
Family
ID=15039148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55130643A Granted JPS5756464A (en) | 1980-09-22 | 1980-09-22 | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5756464A (cs) |
| DE (1) | DE3137674A1 (cs) |
| GB (1) | GB2084150B (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6034160A (ja) * | 1983-08-05 | 1985-02-21 | Nippon Saitetsuku Kk | 保存食品の製法 |
| WO1995015951A1 (fr) * | 1993-12-10 | 1995-06-15 | Kyorin Pharmaceutical Co. Ltd. | Nouveau derive de l'imidazole et sa methode d'obtention |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54109974A (en) * | 1978-02-18 | 1979-08-29 | Kissei Pharmaceut Co Ltd | Novel imidazolecarboxylic ester derivative |
| JPS54109973A (en) * | 1978-02-17 | 1979-08-29 | Kissei Pharmaceut Co Ltd | Novel imidazole derivative |
| JPS54112863A (en) * | 1978-02-20 | 1979-09-04 | Kissei Pharmaceut Co Ltd | N-(omega-carboxyalkyl)imidazole |
| JPS54163573A (en) * | 1978-06-09 | 1979-12-26 | Ono Pharmaceutical Co | Imidazole derivative and method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2016452B (en) * | 1978-02-18 | 1982-07-21 | Kissei Pharmaceutical | Imidazole compounds |
| IT1162310B (it) * | 1978-05-02 | 1987-03-25 | Ono Pharmaceutical Co | Derivati di imidazolo e procedimento per produrli |
| JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
-
1980
- 1980-09-22 JP JP55130643A patent/JPS5756464A/ja active Granted
-
1981
- 1981-09-21 GB GB8128515A patent/GB2084150B/en not_active Expired
- 1981-09-22 DE DE19813137674 patent/DE3137674A1/de active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54109973A (en) * | 1978-02-17 | 1979-08-29 | Kissei Pharmaceut Co Ltd | Novel imidazole derivative |
| JPS54109974A (en) * | 1978-02-18 | 1979-08-29 | Kissei Pharmaceut Co Ltd | Novel imidazolecarboxylic ester derivative |
| JPS54112863A (en) * | 1978-02-20 | 1979-09-04 | Kissei Pharmaceut Co Ltd | N-(omega-carboxyalkyl)imidazole |
| JPS54163573A (en) * | 1978-06-09 | 1979-12-26 | Ono Pharmaceutical Co | Imidazole derivative and method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6034160A (ja) * | 1983-08-05 | 1985-02-21 | Nippon Saitetsuku Kk | 保存食品の製法 |
| WO1995015951A1 (fr) * | 1993-12-10 | 1995-06-15 | Kyorin Pharmaceutical Co. Ltd. | Nouveau derive de l'imidazole et sa methode d'obtention |
| US6103747A (en) * | 1993-12-10 | 2000-08-15 | Kyorin Pharmaceutical Co., Ltd. | Imidazole derivatives and process for preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3137674A1 (de) | 1982-05-19 |
| GB2084150B (en) | 1984-07-04 |
| GB2084150A (en) | 1982-04-07 |
| DE3137674C2 (cs) | 1989-12-28 |
| JPS622586B2 (cs) | 1987-01-20 |
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