JPS5732284A - Preparation of adenine - Google Patents

Preparation of adenine

Info

Publication number
JPS5732284A
JPS5732284A JP10804680A JP10804680A JPS5732284A JP S5732284 A JPS5732284 A JP S5732284A JP 10804680 A JP10804680 A JP 10804680A JP 10804680 A JP10804680 A JP 10804680A JP S5732284 A JPS5732284 A JP S5732284A
Authority
JP
Japan
Prior art keywords
ammonia
formic acid
derivative
adenine
existence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10804680A
Other languages
Japanese (ja)
Other versions
JPS624392B2 (en
Inventor
Jiro Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohjin Holdings Co Ltd
Original Assignee
Kohjin Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kohjin Holdings Co Ltd filed Critical Kohjin Holdings Co Ltd
Priority to JP10804680A priority Critical patent/JPS5732284A/en
Priority to EP83111170A priority patent/EP0118597B1/en
Priority to DE8181106043T priority patent/DE3167196D1/en
Priority to DE8383111170T priority patent/DE3176085D1/en
Priority to EP81106043A priority patent/EP0045503B1/en
Publication of JPS5732284A publication Critical patent/JPS5732284A/en
Priority to US06/571,150 priority patent/US4861883A/en
Publication of JPS624392B2 publication Critical patent/JPS624392B2/ja
Priority to US07/323,709 priority patent/US4997939A/en
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare high-purity adenine in high yield, without isolating the intermediate, by reacting a malononitrile derivative with formic acid (derivative) in the presence of ammonia under heating, and catalytically reducing the product in the absence of ammonia.
CONSTITUTION: A malononitrile derivative of formula (Ar is aryl) (e.g. phenylazomalononitrile) is reacted with formic acid or formic acid or formic acid derivative (e.g. formamide) in the presence of 1.5W10 times mole of ammonia based on the arylazomalononitrile under heating, and the product is reacted under catalytic reduction conditions to obtain adenine. The catalytic reduction is carried out preventing the existence of ammonia, i.e. keeping the amount of ammonia in the reaction system to 0W5wt% based on the liquid component of the system. To prevent the existence of ammonia, it is preferable to use the release of ammonia under hot conditions and the bubbling of gas such as nitrogen gas in combination.
COPYRIGHT: (C)1982,JPO&Japio
JP10804680A 1980-03-21 1980-08-05 Preparation of adenine Granted JPS5732284A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP10804680A JPS5732284A (en) 1980-08-05 1980-08-05 Preparation of adenine
EP83111170A EP0118597B1 (en) 1980-08-05 1981-08-01 Process for preparing adenine
DE8181106043T DE3167196D1 (en) 1980-08-05 1981-08-01 Process for preparing adenine
DE8383111170T DE3176085D1 (en) 1980-08-05 1981-08-01 Process for preparing adenine
EP81106043A EP0045503B1 (en) 1980-08-05 1981-08-01 Process for preparing adenine
US06/571,150 US4861883A (en) 1980-08-05 1984-01-17 Process for preparing adenine
US07/323,709 US4997939A (en) 1980-03-21 1989-03-15 Process for preparing adenine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10804680A JPS5732284A (en) 1980-08-05 1980-08-05 Preparation of adenine

Publications (2)

Publication Number Publication Date
JPS5732284A true JPS5732284A (en) 1982-02-20
JPS624392B2 JPS624392B2 (en) 1987-01-30

Family

ID=14474552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10804680A Granted JPS5732284A (en) 1980-03-21 1980-08-05 Preparation of adenine

Country Status (1)

Country Link
JP (1) JPS5732284A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62200384U (en) * 1986-06-10 1987-12-21

Also Published As

Publication number Publication date
JPS624392B2 (en) 1987-01-30

Similar Documents

Publication Publication Date Title
JPS557239A (en) Preparation of dicarboxylic diester
JPS5732284A (en) Preparation of adenine
JPS5617918A (en) Manufacture of dichlorosilane
JPS5798247A (en) Preparation of monomethylhydrazine
JPS5663944A (en) Reduction of aromatic nitrile
JPS57108072A (en) Preparation of n-acylcarnosine
ES8105304A1 (en) Process for preparing pure cyanuric acid.
ES8502104A1 (en) Process for the preparation of the anhydride of N-formyl-L-aspartic acid
JPS5459228A (en) Preparation of ethylenediamine diacetonitrile
JPS5742660A (en) Preparation of formamide
JPS54157519A (en) Preparation of dimethylformamide
JPS51128998A (en) Process for preparing 4-hydroxy-1h- pyrazolo (3,4-d) pyrimidine
JPS5457488A (en) Acetic acid production catalyst
MY118098A (en) Use of shaped bodies as a catalyst for the production of caprolactam.
JPS5673081A (en) Preparation of tocopherol acetate
JPS55130939A (en) Preparation of carbonic acid ester
MY120160A (en) Preparation of caprolactam
Lissel Phase Transfer Catalysis for Preparation and Alkylation of Ethyl 1, 3-Dithiane-2-carboxylate
JPS56158754A (en) Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate
JPS5373529A (en) Preparation of hydroquinone
JPS565499A (en) Preparation of thymine derivative
JPS5731668A (en) Preparation of 4,5-dicarbamoylimidazole
JPS55136279A (en) Preparation of tryptophan hydantoin
JPS5490184A (en) Preparation of 5-fluoro-orotic acid
JPS56128781A (en) 2-oxo-imidazo(1,2-a)pyridine-3-spiro-4'-piperidine