JPS5732284A - Preparation of adenine - Google Patents
Preparation of adenineInfo
- Publication number
- JPS5732284A JPS5732284A JP10804680A JP10804680A JPS5732284A JP S5732284 A JPS5732284 A JP S5732284A JP 10804680 A JP10804680 A JP 10804680A JP 10804680 A JP10804680 A JP 10804680A JP S5732284 A JPS5732284 A JP S5732284A
- Authority
- JP
- Japan
- Prior art keywords
- ammonia
- formic acid
- derivative
- adenine
- existence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930024421 Adenine Natural products 0.000 title abstract 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000643 adenine Drugs 0.000 title abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 14
- 229910021529 ammonia Inorganic materials 0.000 abstract 7
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 6
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 3
- 235000019253 formic acid Nutrition 0.000 abstract 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical class N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 abstract 2
- KLMBASWITNCMTF-UHFFFAOYSA-N 2-phenyldiazenylpropanedinitrile Chemical compound N#CC(C#N)N=NC1=CC=CC=C1 KLMBASWITNCMTF-UHFFFAOYSA-N 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000005587 bubbling Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910001873 dinitrogen Inorganic materials 0.000 abstract 1
- 150000004675 formic acid derivatives Chemical class 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Abstract
PURPOSE: To prepare high-purity adenine in high yield, without isolating the intermediate, by reacting a malononitrile derivative with formic acid (derivative) in the presence of ammonia under heating, and catalytically reducing the product in the absence of ammonia.
CONSTITUTION: A malononitrile derivative of formula (Ar is aryl) (e.g. phenylazomalononitrile) is reacted with formic acid or formic acid or formic acid derivative (e.g. formamide) in the presence of 1.5W10 times mole of ammonia based on the arylazomalononitrile under heating, and the product is reacted under catalytic reduction conditions to obtain adenine. The catalytic reduction is carried out preventing the existence of ammonia, i.e. keeping the amount of ammonia in the reaction system to 0W5wt% based on the liquid component of the system. To prevent the existence of ammonia, it is preferable to use the release of ammonia under hot conditions and the bubbling of gas such as nitrogen gas in combination.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10804680A JPS5732284A (en) | 1980-08-05 | 1980-08-05 | Preparation of adenine |
EP83111170A EP0118597B1 (en) | 1980-08-05 | 1981-08-01 | Process for preparing adenine |
DE8181106043T DE3167196D1 (en) | 1980-08-05 | 1981-08-01 | Process for preparing adenine |
EP81106043A EP0045503B1 (en) | 1980-08-05 | 1981-08-01 | Process for preparing adenine |
DE8383111170T DE3176085D1 (en) | 1980-08-05 | 1981-08-01 | Process for preparing adenine |
US06/571,150 US4861883A (en) | 1980-08-05 | 1984-01-17 | Process for preparing adenine |
US07/323,709 US4997939A (en) | 1980-03-21 | 1989-03-15 | Process for preparing adenine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10804680A JPS5732284A (en) | 1980-08-05 | 1980-08-05 | Preparation of adenine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5732284A true JPS5732284A (en) | 1982-02-20 |
JPS624392B2 JPS624392B2 (en) | 1987-01-30 |
Family
ID=14474552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10804680A Granted JPS5732284A (en) | 1980-03-21 | 1980-08-05 | Preparation of adenine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732284A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62200384U (en) * | 1986-06-10 | 1987-12-21 |
-
1980
- 1980-08-05 JP JP10804680A patent/JPS5732284A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS624392B2 (en) | 1987-01-30 |
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