JPS5730111B2 - - Google Patents

Info

Publication number
JPS5730111B2
JPS5730111B2 JP1567378A JP1567378A JPS5730111B2 JP S5730111 B2 JPS5730111 B2 JP S5730111B2 JP 1567378 A JP1567378 A JP 1567378A JP 1567378 A JP1567378 A JP 1567378A JP S5730111 B2 JPS5730111 B2 JP S5730111B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP1567378A
Other languages
Japanese (ja)
Other versions
JPS55301A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP1567378A priority Critical patent/JPS55301A/ja
Priority to GB7902546A priority patent/GB2014134B/en
Priority to US06/008,085 priority patent/US4220649A/en
Priority to DE2904552A priority patent/DE2904552C2/de
Priority to FR7903292A priority patent/FR2416889A1/fr
Publication of JPS55301A publication Critical patent/JPS55301A/ja
Publication of JPS5730111B2 publication Critical patent/JPS5730111B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP1567378A 1978-02-14 1978-02-14 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation Granted JPS55301A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP1567378A JPS55301A (en) 1978-02-14 1978-02-14 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
GB7902546A GB2014134B (en) 1978-02-14 1979-01-24 1,4-dihydropyridine 3,5-dicarboxylic acid ester derivatives and process of producing them
US06/008,085 US4220649A (en) 1978-02-14 1979-01-31 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives
DE2904552A DE2904552C2 (de) 1978-02-14 1979-02-07 2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsäure-3-(1-benzylpyrrolidin-3-yl)ester-5-niedrigalkylester
FR7903292A FR2416889A1 (fr) 1978-02-14 1979-02-09 Derives esters de l'acide dihydro-1,4-pyridine-dicarboxylique-3,5, medicaments a base de ces derives et leur procede de production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1567378A JPS55301A (en) 1978-02-14 1978-02-14 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55301A JPS55301A (en) 1980-01-05
JPS5730111B2 true JPS5730111B2 (enExample) 1982-06-26

Family

ID=11895256

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1567378A Granted JPS55301A (en) 1978-02-14 1978-02-14 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation

Country Status (5)

Country Link
US (1) US4220649A (enExample)
JP (1) JPS55301A (enExample)
DE (1) DE2904552C2 (enExample)
FR (1) FR2416889A1 (enExample)
GB (1) GB2014134B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3022002A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-4-carbonsaeureamide, verfahren zu deren herstellung, sowie diese enthaltende arzneimittel
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
ATE50987T1 (de) * 1982-05-10 1990-03-15 Takeda Chemical Industries Ltd Dihydropyridinderivate, deren herstellung und verwendung.
JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
JPS59225162A (ja) * 1983-06-03 1984-12-18 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
DE3382204D1 (de) * 1982-10-15 1991-04-18 Kyowa Hakko Kogyo Kk 1,4-dihydropyridin-derivate.
JPS5970667A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
GR850872B (enExample) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
IT1196272B (it) * 1984-09-28 1988-11-16 Poli Ind Chimica Spa Derivati di 1,4-diidropiridina e composizioni farmaceutiche che li contengono
JPS61158962A (ja) * 1985-01-07 1986-07-18 Teijin Ltd １，４−ジヒドロピリジン誘導体の製造法
AT395976B (de) * 1985-10-19 1993-04-26 Yamanouchi Pharma Co Ltd Verfahren zur herstellung von dihydropyridinverbindungen oder ihren salzen
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
JPS62174017A (ja) * 1986-08-29 1987-07-30 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
US4772596A (en) * 1986-10-09 1988-09-20 Sankyo Company Limited Dihydropyridine derivatives, their preparation and their use
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
EP0306192B1 (en) * 1987-08-28 1992-05-27 Eli Lilly And Company Permeation enhancement compositions
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
EP1285655B1 (en) * 2000-04-11 2007-05-30 Sankyo Company, Limited Stabilized pharmaceutical compositions containing the calcium channel blocker azelnidipine
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
RU2007106714A (ru) * 2004-07-26 2008-09-10 Байер Шеринг Фарма Аг (De) Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
ATE551059T1 (de) * 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
WO2013030725A1 (en) 2011-08-26 2013-03-07 Wockhardt Limited Methods for treating cardiovascular disorders
ITMI20120513A1 (it) 2012-03-29 2013-09-30 Lusochimica Spa Nuove forme polimorfe della barnidipina cloridrato e processi per la loro preparazione
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN119060040A (zh) 2019-01-18 2024-12-03 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3996234A (en) * 1972-04-18 1976-12-07 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
GB1455502A (en) * 1973-02-20 1976-11-10 Yamanouchi Pharma Co Ltd 1,4-dihydropyridine derivatives
DE2549568C3 (de) * 1975-11-05 1981-10-29 Bayer Ag, 5090 Leverkusen 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel

Also Published As

Publication number Publication date
FR2416889B1 (enExample) 1982-09-24
DE2904552A1 (de) 1979-08-16
FR2416889A1 (fr) 1979-09-07
GB2014134B (en) 1982-07-07
JPS55301A (en) 1980-01-05
GB2014134A (en) 1979-08-22
US4220649A (en) 1980-09-02
DE2904552C2 (de) 1986-06-12

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