JPS572256A - Benzylideneaminocarboxylic acid derivative and its preparation - Google Patents

Benzylideneaminocarboxylic acid derivative and its preparation

Info

Publication number
JPS572256A
JPS572256A JP7505580A JP7505580A JPS572256A JP S572256 A JPS572256 A JP S572256A JP 7505580 A JP7505580 A JP 7505580A JP 7505580 A JP7505580 A JP 7505580A JP S572256 A JPS572256 A JP S572256A
Authority
JP
Japan
Prior art keywords
formula
compound shown
trans
methoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7505580A
Other languages
Japanese (ja)
Other versions
JPS6312055B2 (en
Inventor
Hitoshi Takita
Yutaka Mukoda
Mikuo Noda
Hidetoshi Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP7505580A priority Critical patent/JPS572256A/en
Priority to US06/267,250 priority patent/US4382955A/en
Priority to US06/267,249 priority patent/US4377594A/en
Priority to ZA00813532A priority patent/ZA813532B/en
Priority to ZA00813594A priority patent/ZA813594B/en
Priority to AU71168/81A priority patent/AU542972B2/en
Priority to AU71169/81A priority patent/AU538938B2/en
Priority to NO811888A priority patent/NO152253C/en
Priority to EP81302467A priority patent/EP0041827B1/en
Priority to DE8181302467T priority patent/DE3162772D1/en
Priority to CA000378938A priority patent/CA1183150A/en
Priority to DE8181302466T priority patent/DE3161771D1/en
Priority to CA000378962A priority patent/CA1183151A/en
Priority to NO811887A priority patent/NO152252C/en
Priority to EP81302466A priority patent/EP0041826B1/en
Priority to DK248081A priority patent/DK152649C/en
Priority to DK248181A priority patent/DK149769C/en
Publication of JPS572256A publication Critical patent/JPS572256A/en
Publication of JPS6312055B2 publication Critical patent/JPS6312055B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I (X1 is OH, or methoxy; X2 is H, OH or methoxy; m and n are natural number, with the proviso that m+n-5; R is H, or 1W10C alkyl; X3 is H, NA, or 1W4C alkyl).
EXAMPLE: N-( 2-Hydroxybenzylidene )aminomethyl- trans- cyclohexane- carboxylic acid.
USE: Having inhibiting actions on blood platelet aggregation and/or inhibiting action on multinuclear leukocyte migration. A remedy for diseases, e.g., inflammation, thrombus, cerebral apoplexy, hypertension, asthma, etc. an intermediate for drugs.
PROCESS: A compound shown by the formula II is condensed with a trans- or cis- form aminomethylcyclohexane-1-carboxylic acid shown by the formula III or its ester in an organic solvent, e.g., methanol, at ≤150°C, preferably at 0W120°C in an inert gas atmosphere, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP7505580A 1980-06-04 1980-06-04 Benzylideneaminocarboxylic acid derivative and its preparation Granted JPS572256A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP7505580A JPS572256A (en) 1980-06-04 1980-06-04 Benzylideneaminocarboxylic acid derivative and its preparation
US06/267,250 US4382955A (en) 1980-06-04 1981-05-26 Derivative of 4-(N-(3,4-dihydroxybenzylidene) aminomethyl cyclohexane-1-carboxylic acid
US06/267,249 US4377594A (en) 1980-06-04 1981-05-26 Derivative of 4-(N-(substituted-benzylidene)amino-methyl cyclohexane-1-carboxylic acid
ZA00813532A ZA813532B (en) 1980-06-04 1981-05-26 Derivative of 4-(n-(substituted-benzylidene)amino-methyl)cyclohexane-1-carboxylic acid
ZA00813594A ZA813594B (en) 1980-06-04 1981-05-27 Derivative of 4-(n-(3,4-dihydroxybenzylidene)aminomethyl)cyclohexane-1-carboxylic acid
AU71168/81A AU542972B2 (en) 1980-06-04 1981-05-29 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1- carboxylic acids
AU71169/81A AU538938B2 (en) 1980-06-04 1981-05-29 4-(n-(3:,4:-dihydroxybenzylidene)aminoethyl)cyclohexane- 1-carboxylic acid
NO811888A NO152253C (en) 1980-06-04 1981-06-03 ANALOGY PROCEDURE FOR PREPARATION OF 4- (N- (3`, 4'-DIHYDROXYBENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID WITH THERAPEUTIC ACTIVITY
EP81302467A EP0041827B1 (en) 1980-06-04 1981-06-03 A n-(benzylidene) aminomethyl-cyclohexane-carboxylic acid
DE8181302467T DE3162772D1 (en) 1980-06-04 1981-06-03 A N- (BENZYLIDENE) AMINOMETHYL-CYCLOHEXANE-CARBOXYLIC ACID
CA000378938A CA1183150A (en) 1980-06-04 1981-06-03 Derivative of 4-[n-(substituted- benzylidene)aminomethyl]cyclohexane-1-carboxylic acid
DE8181302466T DE3161771D1 (en) 1980-06-04 1981-06-03 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids
CA000378962A CA1183151A (en) 1980-06-04 1981-06-03 Derivative of 4-[n-(3',4'- dihydroxybenzylidene)aminomethyl]cyclohexane-1- carboxylic acid
NO811887A NO152252C (en) 1980-06-04 1981-06-03 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DERIVATIVES OF 4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID
EP81302466A EP0041826B1 (en) 1980-06-04 1981-06-03 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids
DK248081A DK152649C (en) 1980-06-04 1981-06-04 ANALOGY PROCEDURE FOR PREPARING A 4-OEN- (3 ', 4'-DIHYDROXYBENZYLIDE) AMINOMETHYLAACYCLOHEXAN-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF
DK248181A DK149769C (en) 1980-06-04 1981-06-04 METHOD OF ANALOGY FOR THE PREPARATION OF TRANS-4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7505580A JPS572256A (en) 1980-06-04 1980-06-04 Benzylideneaminocarboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS572256A true JPS572256A (en) 1982-01-07
JPS6312055B2 JPS6312055B2 (en) 1988-03-17

Family

ID=13565128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7505580A Granted JPS572256A (en) 1980-06-04 1980-06-04 Benzylideneaminocarboxylic acid derivative and its preparation

Country Status (2)

Country Link
JP (1) JPS572256A (en)
ZA (2) ZA813532B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922881A (en) * 1987-12-29 1990-05-08 Kawasaki Jukogyo Kabushiki Kaisha Breather device for an internal combustion engine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922881A (en) * 1987-12-29 1990-05-08 Kawasaki Jukogyo Kabushiki Kaisha Breather device for an internal combustion engine

Also Published As

Publication number Publication date
ZA813594B (en) 1982-06-30
JPS6312055B2 (en) 1988-03-17
ZA813532B (en) 1982-06-30

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