JPS572256A - Benzylideneaminocarboxylic acid derivative and its preparation - Google Patents
Benzylideneaminocarboxylic acid derivative and its preparationInfo
- Publication number
- JPS572256A JPS572256A JP7505580A JP7505580A JPS572256A JP S572256 A JPS572256 A JP S572256A JP 7505580 A JP7505580 A JP 7505580A JP 7505580 A JP7505580 A JP 7505580A JP S572256 A JPS572256 A JP S572256A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- trans
- methoxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound shown by the formula I (X1 is OH, or methoxy; X2 is H, OH or methoxy; m and n are natural number, with the proviso that m+n-5; R is H, or 1W10C alkyl; X3 is H, NA, or 1W4C alkyl).
EXAMPLE: N-( 2-Hydroxybenzylidene )aminomethyl- trans- cyclohexane- carboxylic acid.
USE: Having inhibiting actions on blood platelet aggregation and/or inhibiting action on multinuclear leukocyte migration. A remedy for diseases, e.g., inflammation, thrombus, cerebral apoplexy, hypertension, asthma, etc. an intermediate for drugs.
PROCESS: A compound shown by the formula II is condensed with a trans- or cis- form aminomethylcyclohexane-1-carboxylic acid shown by the formula III or its ester in an organic solvent, e.g., methanol, at ≤150°C, preferably at 0W120°C in an inert gas atmosphere, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7505580A JPS572256A (en) | 1980-06-04 | 1980-06-04 | Benzylideneaminocarboxylic acid derivative and its preparation |
US06/267,250 US4382955A (en) | 1980-06-04 | 1981-05-26 | Derivative of 4-(N-(3,4-dihydroxybenzylidene) aminomethyl cyclohexane-1-carboxylic acid |
US06/267,249 US4377594A (en) | 1980-06-04 | 1981-05-26 | Derivative of 4-(N-(substituted-benzylidene)amino-methyl cyclohexane-1-carboxylic acid |
ZA00813532A ZA813532B (en) | 1980-06-04 | 1981-05-26 | Derivative of 4-(n-(substituted-benzylidene)amino-methyl)cyclohexane-1-carboxylic acid |
ZA00813594A ZA813594B (en) | 1980-06-04 | 1981-05-27 | Derivative of 4-(n-(3,4-dihydroxybenzylidene)aminomethyl)cyclohexane-1-carboxylic acid |
AU71168/81A AU542972B2 (en) | 1980-06-04 | 1981-05-29 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1- carboxylic acids |
AU71169/81A AU538938B2 (en) | 1980-06-04 | 1981-05-29 | 4-(n-(3:,4:-dihydroxybenzylidene)aminoethyl)cyclohexane- 1-carboxylic acid |
NO811888A NO152253C (en) | 1980-06-04 | 1981-06-03 | ANALOGY PROCEDURE FOR PREPARATION OF 4- (N- (3`, 4'-DIHYDROXYBENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID WITH THERAPEUTIC ACTIVITY |
EP81302467A EP0041827B1 (en) | 1980-06-04 | 1981-06-03 | A n-(benzylidene) aminomethyl-cyclohexane-carboxylic acid |
DE8181302467T DE3162772D1 (en) | 1980-06-04 | 1981-06-03 | A N- (BENZYLIDENE) AMINOMETHYL-CYCLOHEXANE-CARBOXYLIC ACID |
CA000378938A CA1183150A (en) | 1980-06-04 | 1981-06-03 | Derivative of 4-[n-(substituted- benzylidene)aminomethyl]cyclohexane-1-carboxylic acid |
DE8181302466T DE3161771D1 (en) | 1980-06-04 | 1981-06-03 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids |
CA000378962A CA1183151A (en) | 1980-06-04 | 1981-06-03 | Derivative of 4-[n-(3',4'- dihydroxybenzylidene)aminomethyl]cyclohexane-1- carboxylic acid |
NO811887A NO152252C (en) | 1980-06-04 | 1981-06-03 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DERIVATIVES OF 4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID |
EP81302466A EP0041826B1 (en) | 1980-06-04 | 1981-06-03 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids |
DK248081A DK152649C (en) | 1980-06-04 | 1981-06-04 | ANALOGY PROCEDURE FOR PREPARING A 4-OEN- (3 ', 4'-DIHYDROXYBENZYLIDE) AMINOMETHYLAACYCLOHEXAN-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF |
DK248181A DK149769C (en) | 1980-06-04 | 1981-06-04 | METHOD OF ANALOGY FOR THE PREPARATION OF TRANS-4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7505580A JPS572256A (en) | 1980-06-04 | 1980-06-04 | Benzylideneaminocarboxylic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS572256A true JPS572256A (en) | 1982-01-07 |
JPS6312055B2 JPS6312055B2 (en) | 1988-03-17 |
Family
ID=13565128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7505580A Granted JPS572256A (en) | 1980-06-04 | 1980-06-04 | Benzylideneaminocarboxylic acid derivative and its preparation |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS572256A (en) |
ZA (2) | ZA813532B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4922881A (en) * | 1987-12-29 | 1990-05-08 | Kawasaki Jukogyo Kabushiki Kaisha | Breather device for an internal combustion engine |
-
1980
- 1980-06-04 JP JP7505580A patent/JPS572256A/en active Granted
-
1981
- 1981-05-26 ZA ZA00813532A patent/ZA813532B/en unknown
- 1981-05-27 ZA ZA00813594A patent/ZA813594B/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4922881A (en) * | 1987-12-29 | 1990-05-08 | Kawasaki Jukogyo Kabushiki Kaisha | Breather device for an internal combustion engine |
Also Published As
Publication number | Publication date |
---|---|
ZA813594B (en) | 1982-06-30 |
JPS6312055B2 (en) | 1988-03-17 |
ZA813532B (en) | 1982-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU92016313A (en) | NEW ANALOGUES OF VITAMIN D, METHOD OF THEIR PRODUCTION, INTERMEDIATE CONNECTION, FORMCOMPOSITION AND METHOD OF TREATMENT | |
JPS5427520A (en) | Purification of crude acrylic acid | |
JPS57106638A (en) | Conjugated polyprenylcarboxylic acid and its derivative | |
JPS572256A (en) | Benzylideneaminocarboxylic acid derivative and its preparation | |
JPS5289640A (en) | Guanidinobenzoic acid derivatives, and antiplasmin agents and remedies for pancreas diseases containing the said guanidinobensolc acid deriv atives | |
JPS56154433A (en) | Quinone compound and its preparation | |
JPS56118015A (en) | Immunological activator containing organic germanium compound | |
JPS57109739A (en) | Quinone compound and its preparation | |
JPS57192340A (en) | Isoprenylamine derivative | |
JPS57116035A (en) | Novel benzylideneaminocarboxylic acid derivative and its preparation | |
JPS57192342A (en) | Isoprenylamine derivative | |
JPS56103178A (en) | Pyrimidinoaminomethylenemalonic cyclic ester and its preparation | |
JPS5285169A (en) | Novel allantoin-n-acetylglutamine-aluminum molecular complex and its p reparation | |
JPS53130623A (en) | Preparation of n-hydroxyalkyl-substituted phosphoroamidate | |
JPS5233662A (en) | Preparation of n2-naphthalenesulfonyl-alginamides and acid addition sa lts thereof | |
JPS56103197A (en) | Novel d-glucose derivative and antitumor agent containing the same as active constitutent | |
JPS53127885A (en) | Purification of urokinase | |
JPS54141764A (en) | 1-(4-tert-butyl)benzoyl derivative and fungicides comprising it | |
JPS5347439A (en) | Coloring of high molecular weight material | |
JPS5726700A (en) | Purification of chenodeoxycholic acid | |
JPS5416458A (en) | Preparation of oxime substituted phenylacetic acid derivatives | |
JPS5489040A (en) | Anti-ulcer agent | |
JPS56123980A (en) | Phloroglucin derivative | |
JPS56113731A (en) | Quinone compound and its preparation | |
JPS56129221A (en) | Oil-free alkyd resin |