JPS5726700A - Purification of chenodeoxycholic acid - Google Patents
Purification of chenodeoxycholic acidInfo
- Publication number
- JPS5726700A JPS5726700A JP10224180A JP10224180A JPS5726700A JP S5726700 A JPS5726700 A JP S5726700A JP 10224180 A JP10224180 A JP 10224180A JP 10224180 A JP10224180 A JP 10224180A JP S5726700 A JPS5726700 A JP S5726700A
- Authority
- JP
- Japan
- Prior art keywords
- liquid chromatography
- filler
- mixture
- organic solvent
- fixed phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a dissolving agent for gallstone simply and in high purity, by purifying crude chenodoxycholic acid by liquid chromatography using a filler having specific properties as a fixed phase.
CONSTITUTION: Crude chenodeoxycholic acid is purified by liquid chromatography using a filler for liquid chromatography consisting of a porous polymer as a fixed phase obtained by subjecting a mixture comprising 100pts.wt. compound (e.g., triethylene glycol diacrylate, etc.) shown by the formula (R1 and R2 are H or methyl; n is 3W18) and 5W60pts.wt. x methylolalkyl y(meth)acrylate (x and y are integer, x≥y≥3) (tetramethylolmethane tetraacrylate, etc.) to aqueous suspension polymerization in the presence of an organic solvent and using water with pH≥6.5 as an eluent. The organic solvent dissolves the mixture but not its polymer and toluene, xylene, etc. may be cited as the solvent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10224180A JPS5726700A (en) | 1980-07-24 | 1980-07-24 | Purification of chenodeoxycholic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10224180A JPS5726700A (en) | 1980-07-24 | 1980-07-24 | Purification of chenodeoxycholic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5726700A true JPS5726700A (en) | 1982-02-12 |
JPS6123800B2 JPS6123800B2 (en) | 1986-06-07 |
Family
ID=14322124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10224180A Granted JPS5726700A (en) | 1980-07-24 | 1980-07-24 | Purification of chenodeoxycholic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726700A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5987150A (en) * | 1982-11-11 | 1984-05-19 | 三菱瓦斯化学株式会社 | Manufacture of copper lined laminated board |
JPS60139755A (en) * | 1983-12-27 | 1985-07-24 | Ube Ind Ltd | Electrical insulating composition |
JPS62106960A (en) * | 1985-11-01 | 1987-05-18 | Nippon Koudoshi Kogyo Kk | Heat-resistant resin composition |
-
1980
- 1980-07-24 JP JP10224180A patent/JPS5726700A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5987150A (en) * | 1982-11-11 | 1984-05-19 | 三菱瓦斯化学株式会社 | Manufacture of copper lined laminated board |
JPS60139755A (en) * | 1983-12-27 | 1985-07-24 | Ube Ind Ltd | Electrical insulating composition |
JPS62106960A (en) * | 1985-11-01 | 1987-05-18 | Nippon Koudoshi Kogyo Kk | Heat-resistant resin composition |
Also Published As
Publication number | Publication date |
---|---|
JPS6123800B2 (en) | 1986-06-07 |
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