JPS5726700A - Purification of chenodeoxycholic acid - Google Patents

Purification of chenodeoxycholic acid

Info

Publication number
JPS5726700A
JPS5726700A JP10224180A JP10224180A JPS5726700A JP S5726700 A JPS5726700 A JP S5726700A JP 10224180 A JP10224180 A JP 10224180A JP 10224180 A JP10224180 A JP 10224180A JP S5726700 A JPS5726700 A JP S5726700A
Authority
JP
Japan
Prior art keywords
liquid chromatography
filler
mixture
organic solvent
fixed phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10224180A
Other languages
Japanese (ja)
Other versions
JPS6123800B2 (en
Inventor
Minoru Obara
Fumio Kamiyama
Mitsuo Nagata
Takashi Kamata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sekisui Chemical Co Ltd
Original Assignee
Sekisui Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Chemical Co Ltd filed Critical Sekisui Chemical Co Ltd
Priority to JP10224180A priority Critical patent/JPS5726700A/en
Publication of JPS5726700A publication Critical patent/JPS5726700A/en
Publication of JPS6123800B2 publication Critical patent/JPS6123800B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as a dissolving agent for gallstone simply and in high purity, by purifying crude chenodoxycholic acid by liquid chromatography using a filler having specific properties as a fixed phase.
CONSTITUTION: Crude chenodeoxycholic acid is purified by liquid chromatography using a filler for liquid chromatography consisting of a porous polymer as a fixed phase obtained by subjecting a mixture comprising 100pts.wt. compound (e.g., triethylene glycol diacrylate, etc.) shown by the formula (R1 and R2 are H or methyl; n is 3W18) and 5W60pts.wt. x methylolalkyl y(meth)acrylate (x and y are integer, x≥y≥3) (tetramethylolmethane tetraacrylate, etc.) to aqueous suspension polymerization in the presence of an organic solvent and using water with pH≥6.5 as an eluent. The organic solvent dissolves the mixture but not its polymer and toluene, xylene, etc. may be cited as the solvent.
COPYRIGHT: (C)1982,JPO&Japio
JP10224180A 1980-07-24 1980-07-24 Purification of chenodeoxycholic acid Granted JPS5726700A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10224180A JPS5726700A (en) 1980-07-24 1980-07-24 Purification of chenodeoxycholic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10224180A JPS5726700A (en) 1980-07-24 1980-07-24 Purification of chenodeoxycholic acid

Publications (2)

Publication Number Publication Date
JPS5726700A true JPS5726700A (en) 1982-02-12
JPS6123800B2 JPS6123800B2 (en) 1986-06-07

Family

ID=14322124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10224180A Granted JPS5726700A (en) 1980-07-24 1980-07-24 Purification of chenodeoxycholic acid

Country Status (1)

Country Link
JP (1) JPS5726700A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5987150A (en) * 1982-11-11 1984-05-19 三菱瓦斯化学株式会社 Manufacture of copper lined laminated board
JPS60139755A (en) * 1983-12-27 1985-07-24 Ube Ind Ltd Electrical insulating composition
JPS62106960A (en) * 1985-11-01 1987-05-18 Nippon Koudoshi Kogyo Kk Heat-resistant resin composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5987150A (en) * 1982-11-11 1984-05-19 三菱瓦斯化学株式会社 Manufacture of copper lined laminated board
JPS60139755A (en) * 1983-12-27 1985-07-24 Ube Ind Ltd Electrical insulating composition
JPS62106960A (en) * 1985-11-01 1987-05-18 Nippon Koudoshi Kogyo Kk Heat-resistant resin composition

Also Published As

Publication number Publication date
JPS6123800B2 (en) 1986-06-07

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