JPS57188547A - Preparation of 4-aminomethylcyclohexane-1-carboxylic acid - Google Patents

Preparation of 4-aminomethylcyclohexane-1-carboxylic acid

Info

Publication number
JPS57188547A
JPS57188547A JP56070777A JP7077781A JPS57188547A JP S57188547 A JPS57188547 A JP S57188547A JP 56070777 A JP56070777 A JP 56070777A JP 7077781 A JP7077781 A JP 7077781A JP S57188547 A JPS57188547 A JP S57188547A
Authority
JP
Japan
Prior art keywords
water
solvent
alkali
treating
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56070777A
Other languages
Japanese (ja)
Other versions
JPH0113461B2 (en
Inventor
Riyuuji Aoki
Jiro Hayakawa
Kenji Ooshiki
Ryugo Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DEITSUKU FINE CHEMICAL KK
Dic Fine Chemicals Inc
Original Assignee
DEITSUKU FINE CHEMICAL KK
Dic Fine Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DEITSUKU FINE CHEMICAL KK, Dic Fine Chemicals Inc filed Critical DEITSUKU FINE CHEMICAL KK
Priority to JP56070777A priority Critical patent/JPS57188547A/en
Publication of JPS57188547A publication Critical patent/JPS57188547A/en
Publication of JPH0113461B2 publication Critical patent/JPH0113461B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

PURPOSE: To prepare the titled compound useful as an antiplasminic agent, with direct single-step process, under mild conditions, in high yield, by treating terephthalo-nitrile with hydrogen in a solvent comprising water or a mixture of water and a hydrophilic organic solvent, in the presence of an alkali, etc.
CONSTITUTION: The objective compound can be prepared by treating terephthalonitrile (TPN) with hydrogen in a solvent comprising water or a mixture of water and a hydrophilic organic solvent (e.g. ethanol, propanol, etc.) in the presence of an alkali or alkaline earth metal hydroxide (e.g. caustic soda, caustic potash, etc.) and a metal catalyst for hydrogenation (pref. the combination of Pd and Ru). Since water can be singly used as the reaction solvent, and since it is effective for the smooth reaction, the process is advantageous from industrial viewpoint. The presence of the alkali increases the content of the trans-isomer which is the active component of the objective compound, and accordingly, results in various advantages such as reduction of the purification load of an ion exchange resin.
COPYRIGHT: (C)1982,JPO&Japio
JP56070777A 1981-05-13 1981-05-13 Preparation of 4-aminomethylcyclohexane-1-carboxylic acid Granted JPS57188547A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56070777A JPS57188547A (en) 1981-05-13 1981-05-13 Preparation of 4-aminomethylcyclohexane-1-carboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56070777A JPS57188547A (en) 1981-05-13 1981-05-13 Preparation of 4-aminomethylcyclohexane-1-carboxylic acid

Publications (2)

Publication Number Publication Date
JPS57188547A true JPS57188547A (en) 1982-11-19
JPH0113461B2 JPH0113461B2 (en) 1989-03-06

Family

ID=13441284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56070777A Granted JPS57188547A (en) 1981-05-13 1981-05-13 Preparation of 4-aminomethylcyclohexane-1-carboxylic acid

Country Status (1)

Country Link
JP (1) JPS57188547A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105712863A (en) * 2015-02-12 2016-06-29 江苏永达药业有限公司 Process for producing trans-acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105712863A (en) * 2015-02-12 2016-06-29 江苏永达药业有限公司 Process for producing trans-acid

Also Published As

Publication number Publication date
JPH0113461B2 (en) 1989-03-06

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