JPS5718619A - Tumor immunotherapy agent containing lipopolysaccharide as active principle - Google Patents
Tumor immunotherapy agent containing lipopolysaccharide as active principleInfo
- Publication number
- JPS5718619A JPS5718619A JP9424780A JP9424780A JPS5718619A JP S5718619 A JPS5718619 A JP S5718619A JP 9424780 A JP9424780 A JP 9424780A JP 9424780 A JP9424780 A JP 9424780A JP S5718619 A JPS5718619 A JP S5718619A
- Authority
- JP
- Japan
- Prior art keywords
- lipopolysaccharide
- active principle
- immunotherapy agent
- arabinomannan
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: The titled immunotherapy agent that contains lipopolysaccharide obtained from arabinomannan in Mycobacterium tuberculosis and a fatty acid as an active principle, thus showing higher activity and lower side-effects than naturally occurring lipoarabinomannan.
CONSTITUTION: The cell bodies of Mycobacterium tuberculosis H37Rv strain are extracted with hot water or an alkali and the extract is purified to give arabinomannan. The resultant arabinomannan is used as a polysaccharide and a fatty acid is employed to give a lipopolysaccharide of 1W28% fatty acid content and the lipopolysaccharide is used as an active principle to give the objective tumor immunotherapy agent. Further, the lipopolysaccharide may be modified with fatty acids. The fatty acids used are palmitic, myristic and oleic acids and the polysaccharide is composed of 30W74% arabinose, 20W50% mannose, 0W10% glucose and 0W 13% galactose. The lipopolysaccharide is simple in chemical composition and removes side-effects caused by cell bodies.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9424780A JPS5718619A (en) | 1980-07-10 | 1980-07-10 | Tumor immunotherapy agent containing lipopolysaccharide as active principle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9424780A JPS5718619A (en) | 1980-07-10 | 1980-07-10 | Tumor immunotherapy agent containing lipopolysaccharide as active principle |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5718619A true JPS5718619A (en) | 1982-01-30 |
Family
ID=14104968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9424780A Pending JPS5718619A (en) | 1980-07-10 | 1980-07-10 | Tumor immunotherapy agent containing lipopolysaccharide as active principle |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5718619A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998056941A1 (en) * | 1995-12-12 | 1998-12-17 | Tai Ho Chung | Carbohydrate complex extracted from mycobacterium tuberculosis and process for the preparation thereof |
US6282729B1 (en) | 1996-12-20 | 2001-09-04 | Gunze Limited | Waist protection member |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS568320A (en) * | 1979-07-04 | 1981-01-28 | Chisato Maruyama | Drug for tumor immunotherapy comprising lipopolysaccharide as active constituent |
-
1980
- 1980-07-10 JP JP9424780A patent/JPS5718619A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS568320A (en) * | 1979-07-04 | 1981-01-28 | Chisato Maruyama | Drug for tumor immunotherapy comprising lipopolysaccharide as active constituent |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998056941A1 (en) * | 1995-12-12 | 1998-12-17 | Tai Ho Chung | Carbohydrate complex extracted from mycobacterium tuberculosis and process for the preparation thereof |
US6282729B1 (en) | 1996-12-20 | 2001-09-04 | Gunze Limited | Waist protection member |
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