JPS5798218A - Production of adjuvant-active substance - Google Patents
Production of adjuvant-active substanceInfo
- Publication number
- JPS5798218A JPS5798218A JP16954881A JP16954881A JPS5798218A JP S5798218 A JPS5798218 A JP S5798218A JP 16954881 A JP16954881 A JP 16954881A JP 16954881 A JP16954881 A JP 16954881A JP S5798218 A JPS5798218 A JP S5798218A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- cmi
- treated
- acid
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: D-CMI-A substance is treated with an acid to produce the titled D- CMI-B substance with reduced side-effects.
CONSTITUTION: The wax D substance is treated with a polar solvent such as methanol, acetone, chloroform-methanol mixed solvent at room or elevated temperature. The resultant D-CMI substance is treated with a protease such as tripsin, chymotripsin or pronase to remove substances causing allergic reactions such as tuberculin protein and give D-CMI-A substance. The D-CMI-A substance is treated with an acid such as periodic acid or periodate salt in solvent such as water or ethanol to give the D-CMI-B substance. The wax D substance contains mycolic acid, arabinogalactan and mucopeptide as the base structure and is obtained from cell bodies of a bacterium such as Mycobacterium.
EFFECT: The resultant substance causes no allergic shock, since it is free from antibiotics, and has the same level of adjuvant and anticancer activites as that of the D-CMI-A substance.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16954881A JPS58410B2 (en) | 1981-10-22 | 1981-10-22 | Method of manufacturing adjuvant active substances |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16954881A JPS58410B2 (en) | 1981-10-22 | 1981-10-22 | Method of manufacturing adjuvant active substances |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2880174A Division JPS5729449B2 (en) | 1974-03-12 | 1974-03-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5798218A true JPS5798218A (en) | 1982-06-18 |
JPS58410B2 JPS58410B2 (en) | 1983-01-06 |
Family
ID=15888510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16954881A Expired JPS58410B2 (en) | 1981-10-22 | 1981-10-22 | Method of manufacturing adjuvant active substances |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS58410B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017025758A1 (en) * | 2015-08-13 | 2017-02-16 | Diagnostig Ltd | Compositions and methods |
-
1981
- 1981-10-22 JP JP16954881A patent/JPS58410B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017025758A1 (en) * | 2015-08-13 | 2017-02-16 | Diagnostig Ltd | Compositions and methods |
US10782293B2 (en) | 2015-08-13 | 2020-09-22 | Diagnostig Ltd | Compositions and methods |
Also Published As
Publication number | Publication date |
---|---|
JPS58410B2 (en) | 1983-01-06 |
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