JPS57179122A - Blood coagulation factor ix preparation for oral administration - Google Patents
Blood coagulation factor ix preparation for oral administrationInfo
- Publication number
- JPS57179122A JPS57179122A JP56065685A JP6568581A JPS57179122A JP S57179122 A JPS57179122 A JP S57179122A JP 56065685 A JP56065685 A JP 56065685A JP 6568581 A JP6568581 A JP 6568581A JP S57179122 A JPS57179122 A JP S57179122A
- Authority
- JP
- Japan
- Prior art keywords
- blood coagulation
- coagulation factor
- liposome
- contents
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010076282 Factor IX Proteins 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000002775 capsule Substances 0.000 abstract 4
- 239000002502 liposome Substances 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 238000000354 decomposition reaction Methods 0.000 abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 2
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 229940019700 blood coagulation factors Drugs 0.000 abstract 1
- 230000009849 deactivation Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56065685A JPS57179122A (en) | 1981-04-28 | 1981-04-28 | Blood coagulation factor ix preparation for oral administration |
| US06/309,269 US4348384A (en) | 1980-10-17 | 1981-10-07 | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56065685A JPS57179122A (en) | 1981-04-28 | 1981-04-28 | Blood coagulation factor ix preparation for oral administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57179122A true JPS57179122A (en) | 1982-11-04 |
| JPH03851B2 JPH03851B2 (https=) | 1991-01-09 |
Family
ID=13294104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56065685A Granted JPS57179122A (en) | 1980-10-17 | 1981-04-28 | Blood coagulation factor ix preparation for oral administration |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57179122A (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60188328A (ja) * | 1984-02-07 | 1985-09-25 | インターフエロン・サイエンシズ・インコーポレーテツド | インターフエロン投与用ビヒクル |
| WO1995022981A1 (en) * | 1994-02-24 | 1995-08-31 | Nippon Chemiphar Co., Ltd. | Oral synthetic peptide preparation |
| JP2001514209A (ja) * | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ，インコーポレイテッド | 経口リポソーム送達系 |
-
1981
- 1981-04-28 JP JP56065685A patent/JPS57179122A/ja active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60188328A (ja) * | 1984-02-07 | 1985-09-25 | インターフエロン・サイエンシズ・インコーポレーテツド | インターフエロン投与用ビヒクル |
| WO1995022981A1 (en) * | 1994-02-24 | 1995-08-31 | Nippon Chemiphar Co., Ltd. | Oral synthetic peptide preparation |
| JP2001514209A (ja) * | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ，インコーポレイテッド | 経口リポソーム送達系 |
| JP2010001317A (ja) * | 1997-09-04 | 2010-01-07 | Biozone Lab Inc | 経口リポソーム送達系 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03851B2 (https=) | 1991-01-09 |
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