JPS5716898A - Prostaglandin controller containing aminobenzoic derivative - Google Patents

Prostaglandin controller containing aminobenzoic derivative

Info

Publication number
JPS5716898A
JPS5716898A JP9111380A JP9111380A JPS5716898A JP S5716898 A JPS5716898 A JP S5716898A JP 9111380 A JP9111380 A JP 9111380A JP 9111380 A JP9111380 A JP 9111380A JP S5716898 A JPS5716898 A JP S5716898A
Authority
JP
Japan
Prior art keywords
formula
prostaglandin
controller
day
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9111380A
Other languages
Japanese (ja)
Other versions
JPH0222047B2 (en
Inventor
Chikao Yoshikumi
Fumio Hirose
Yoshio Omura
Takami Fujii
Masanori Ubusawa
Kenichi Matsunaga
Minoru Ohara
Takao Ando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/081,190 priority Critical patent/US4322408A/en
Priority to US06/084,467 priority patent/US4322409A/en
Priority to US06/102,224 priority patent/US4315921A/en
Priority to US06/102,535 priority patent/US4313939A/en
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP9111380A priority patent/JPS5716898A/en
Priority to AU61008/80A priority patent/AU538455B2/en
Priority to US06/174,543 priority patent/US4440757A/en
Priority to ZA00804723A priority patent/ZA804723B/en
Priority to US06/175,827 priority patent/US4380536A/en
Priority to SE8005575A priority patent/SE453637B/en
Priority to FR8017664A priority patent/FR2485926A1/en
Priority to PH24436A priority patent/PH15186A/en
Priority to CH611380A priority patent/CH644018A5/en
Priority to DE19803030892 priority patent/DE3030892A1/en
Priority to GB8026553A priority patent/GB2056856B/en
Priority to IT24185/80A priority patent/IT1132413B/en
Priority to DE3051068A priority patent/DE3051068C2/de
Priority to CA000363397A priority patent/CA1158163A/en
Priority to BE0/203619A priority patent/BE887260A/en
Priority to US06/294,502 priority patent/US4450156A/en
Publication of JPS5716898A publication Critical patent/JPS5716898A/en
Priority to US06/772,477 priority patent/US4657895A/en
Publication of JPH0222047B2 publication Critical patent/JPH0222047B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

PURPOSE: The titled controller that contains an aminobenzoic acid derivative as an active principle, thus permitting long-period administration because of its high safety.
CONSTITUTION: The prostaglandin controller is obtained by using alone an aminobenzoic acid derivative of the formula (R1 is residue of monosaccharide; R2 is H, metal, 1W4C alkyl) by an amount of 0.01W100wt% or mixing the same with a diluent and other medicines. The compound of the formula is extremely low-toxicity and inactive against microorganisms, therefore it permits the long-term administration. Further, there is no danger to healthy people such as teratologenecity or allergic action. The compound of the formula controls PGs and their metabolites and increase blood platelet coagulation inhibition and cyclic AMP in blood platelets and cultured cells. The oral dose is 0.1W500mg/kg, day and parenteral dose is 0.01W200mg/kg, day.
COPYRIGHT: (C)1982,JPO&Japio
JP9111380A 1978-04-06 1980-07-03 Prostaglandin controller containing aminobenzoic derivative Granted JPS5716898A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
US06/081,190 US4322408A (en) 1978-04-06 1979-10-02 Pharmaceutical composition containing a derivative of para-aminobenzoic acid as an active ingredient
US06/084,467 US4322409A (en) 1978-04-06 1979-10-12 Pharmaceutical composition containing a derivative of orthoaminobenzoic acid as an active ingredient
US06/102,224 US4315921A (en) 1978-04-06 1979-12-10 Pharmaceutical composition containing fara-amino-benzoic acid-N-D-xyloside as an active ingredient
US06/102,535 US4313939A (en) 1978-04-06 1979-12-11 Pharmaceutical composition containing para-aminobenzoic acid-N-L-rhamnoside as an active ingredient
JP9111380A JPS5716898A (en) 1980-07-03 1980-07-03 Prostaglandin controller containing aminobenzoic derivative
AU61008/80A AU538455B2 (en) 1980-07-03 1980-08-01 N-glycosidal aminobenzoic acids
US06/174,543 US4440757A (en) 1978-04-06 1980-08-01 Pharmaceutical composition comprising derivative of aminobenzoic acid for regulating prostaglandin
ZA00804723A ZA804723B (en) 1980-07-03 1980-08-04 Pharmaceutical composition comprising derivative of aminobenzoic acid for regulating prostaglandin
US06/175,827 US4380536A (en) 1978-04-06 1980-08-05 Pharmaceutical composition containing para-amino-benzoic acid-N-D-mannoside as an active ingredient
SE8005575A SE453637B (en) 1980-07-03 1980-08-06 APPLICATION OF DERIVATIVES OF AMINOBENOIC ACID FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION WITH PREVENTIONAL OR DETERMINING EFFECTS ON STENOCARDI, ARRYTHMIA, CEREBRAL INFARCT, MYOCARDIAL INFRASTRUCTURE, CEREBRAL APOPLEXY OR
FR8017664A FR2485926A1 (en) 1980-07-03 1980-08-11 PHARMACEUTICAL COMPOSITION COMPRISING AN AMINOBENZOIC ACID DERIVATIVE TO REGULATE PROSTAGLANDINS
PH24436A PH15186A (en) 1980-07-03 1980-08-12 Method of regulating the production and metabolism of prostaglandin in a mammal
CH611380A CH644018A5 (en) 1980-07-03 1980-08-13 PHARMACEUTICAL AGENT FOR PROSTAGLAND REGULATION.
DE19803030892 DE3030892A1 (en) 1980-07-03 1980-08-14 AGENT FOR CONTROLLING THE PRODUCTION AND METABOLISM OF PROSTAGLANDIN IN MAMMALS
GB8026553A GB2056856B (en) 1980-07-03 1980-08-14 Pharmaceutical compositions comprising aminobenzoic acid derivatives
IT24185/80A IT1132413B (en) 1980-07-03 1980-08-14 PROCEDURE FOR THE PRODUCTION OF INJECTION PRINTED ITEMS WITH IMPROVED SURFACE CHARACTERISTICS, EQUIPMENT FOR THE EXECUTION OF SUCH PROCEDURE AND ITEMS SO OBTAINED
DE3051068A DE3051068C2 (en) 1980-07-03 1980-08-14
CA000363397A CA1158163A (en) 1980-07-03 1980-10-28 Pharmaceutical composition comprising derivative of aminobenzoic acid for regulating prostaglandin
BE0/203619A BE887260A (en) 1980-07-03 1981-01-28 PHARMACEUTICAL COMPOSITION COMPRISING A DERIVATIVE OF AMINOBENZOIC ACID FOR REGULATING PROSTAGLANDINS
US06/294,502 US4450156A (en) 1978-04-06 1981-08-20 Pharmaceutical composition containing a derivative of ortho-aminobenzoic acid as an active ingredient
US06/772,477 US4657895A (en) 1978-04-06 1985-09-04 Pharmaceutical composition containing para-aminobenzoic acid-N-L-rhamnoside as an active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9111380A JPS5716898A (en) 1980-07-03 1980-07-03 Prostaglandin controller containing aminobenzoic derivative

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP15362589A Division JPH0236191A (en) 1989-06-16 1989-06-16 Anticardiopathic agent consisting of aminobenzoic acid derivative
JP1153624A Division JPH0236190A (en) 1989-06-16 1989-06-16 Anticerebropathic agent consisting of aminobenzoic acid derivative

Publications (2)

Publication Number Publication Date
JPS5716898A true JPS5716898A (en) 1982-01-28
JPH0222047B2 JPH0222047B2 (en) 1990-05-17

Family

ID=14017455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9111380A Granted JPS5716898A (en) 1978-04-06 1980-07-03 Prostaglandin controller containing aminobenzoic derivative

Country Status (12)

Country Link
JP (1) JPS5716898A (en)
AU (1) AU538455B2 (en)
BE (1) BE887260A (en)
CA (1) CA1158163A (en)
CH (1) CH644018A5 (en)
DE (2) DE3030892A1 (en)
FR (1) FR2485926A1 (en)
GB (1) GB2056856B (en)
IT (1) IT1132413B (en)
PH (1) PH15186A (en)
SE (1) SE453637B (en)
ZA (1) ZA804723B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104317A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Agent for preventing ishemic cardiopathy containing aminobenzoic acid derivative as an active ingredient
JPS59104318A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Antithrombotic agent containing aminobenzoic acid derivative as an active ingredient
JPS59104316A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Agent for preventing ishemic cerebropathy containing aminobenzoic acid derivative

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU554396B2 (en) * 1982-12-03 1986-08-21 Kureha Kagaku Kogyo K.K. Pharmaceutical compositions of amino benzoic acid derivatives
JPS62289594A (en) * 1986-06-09 1987-12-16 Kureha Chem Ind Co Ltd Sorbitol accumulation inhibitor composed of aminobenzoic acid derivative
JPH06247861A (en) * 1993-02-26 1994-09-06 Yakult Honsha Co Ltd Antiulcer agent and its production
FR2728790B1 (en) * 1994-12-29 1997-01-24 Cird Galderma COMPOSITION MODULATING APOPTOSIS COMPRISING METHONIAL OR ANY FACTOR INFLUENCING THE INTRACELLULAR METHONIAL RATE

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54132239A (en) * 1978-04-06 1979-10-15 Kureha Chem Ind Co Ltd Anti-tumor agent
JPS54135232A (en) * 1978-04-10 1979-10-20 Kureha Chem Ind Co Ltd Blood sugar depressing agent
JPS54135231A (en) * 1978-04-10 1979-10-20 Kureha Chem Ind Co Ltd Cardio-vasocular medicine
JPS54135738A (en) * 1978-04-11 1979-10-22 Kureha Chem Ind Co Ltd Novel aminobenzoic acid-n-d-mannoside and drugs comprising it
JPS54154729A (en) * 1978-05-26 1979-12-06 Kureha Chem Ind Co Ltd Aminobenzoic acid derivative and drug preparation containing the same
JPS5592320A (en) * 1978-12-29 1980-07-12 Kureha Chem Ind Co Ltd Anti-inflammatory agent comprising aminobenzoic acid as active constituent
JPS5592319A (en) * 1978-12-29 1980-07-12 Kureha Chem Ind Co Ltd Central nervous system depressant comprising aminobenzoic acid derivative as active constituent
JPS5634629A (en) * 1979-08-30 1981-04-06 Kureha Chem Ind Co Ltd Anti-arteriosclerotic agent containing aminobenzoic acid derivative as effective component

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE448602B (en) * 1978-04-06 1987-03-09 Kureha Chemical Ind Co Ltd Compsn. contg. para-amino-benzoic acid glycoside
SE446299B (en) * 1978-04-11 1986-09-01 Kureha Chemical Ind Co Ltd MEDICAL COMPOSITION CONTAINING A DERIVATIVE OF PARA-AMINOBENOIC ACID AS ACTIVE INGREDIENT
CH640411A5 (en) * 1978-05-26 1984-01-13 Kureha Chemical Ind Co Ltd MEDICINE FOR TREATING HYPERGLYKAEMIA, HYPERLIPAEMIA, HYPERTENSION, INFLAMMATION, PAIN, FEVER, OR TUMOR.
JPS6041079B2 (en) * 1979-12-14 1985-09-13 呉羽化学工業株式会社 Ortho- or meta-aminobenzoic acid derivatives

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54132239A (en) * 1978-04-06 1979-10-15 Kureha Chem Ind Co Ltd Anti-tumor agent
JPS54135232A (en) * 1978-04-10 1979-10-20 Kureha Chem Ind Co Ltd Blood sugar depressing agent
JPS54135231A (en) * 1978-04-10 1979-10-20 Kureha Chem Ind Co Ltd Cardio-vasocular medicine
JPS54135738A (en) * 1978-04-11 1979-10-22 Kureha Chem Ind Co Ltd Novel aminobenzoic acid-n-d-mannoside and drugs comprising it
JPS54154729A (en) * 1978-05-26 1979-12-06 Kureha Chem Ind Co Ltd Aminobenzoic acid derivative and drug preparation containing the same
JPS5592320A (en) * 1978-12-29 1980-07-12 Kureha Chem Ind Co Ltd Anti-inflammatory agent comprising aminobenzoic acid as active constituent
JPS5592319A (en) * 1978-12-29 1980-07-12 Kureha Chem Ind Co Ltd Central nervous system depressant comprising aminobenzoic acid derivative as active constituent
JPS5634629A (en) * 1979-08-30 1981-04-06 Kureha Chem Ind Co Ltd Anti-arteriosclerotic agent containing aminobenzoic acid derivative as effective component

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104317A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Agent for preventing ishemic cardiopathy containing aminobenzoic acid derivative as an active ingredient
JPS59104318A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Antithrombotic agent containing aminobenzoic acid derivative as an active ingredient
JPS59104316A (en) * 1982-12-03 1984-06-16 Kureha Chem Ind Co Ltd Agent for preventing ishemic cerebropathy containing aminobenzoic acid derivative

Also Published As

Publication number Publication date
FR2485926A1 (en) 1982-01-08
AU6100880A (en) 1982-01-07
GB2056856A (en) 1981-03-25
JPH0222047B2 (en) 1990-05-17
BE887260A (en) 1981-07-28
SE453637B (en) 1988-02-22
SE8005575L (en) 1982-01-04
FR2485926B1 (en) 1985-03-01
PH15186A (en) 1982-09-10
AU538455B2 (en) 1984-08-16
GB2056856B (en) 1984-05-10
ZA804723B (en) 1981-08-26
DE3030892A1 (en) 1982-01-28
IT8024185A0 (en) 1980-08-14
CH644018A5 (en) 1984-07-13
CA1158163A (en) 1983-12-06
DE3051068C2 (en) 1989-05-18
IT1132413B (en) 1986-07-02

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