JPS57165352A - Manufacture of l-carnitine - Google Patents

Manufacture of l-carnitine

Info

Publication number
JPS57165352A
JPS57165352A JP57041794A JP4179482A JPS57165352A JP S57165352 A JPS57165352 A JP S57165352A JP 57041794 A JP57041794 A JP 57041794A JP 4179482 A JP4179482 A JP 4179482A JP S57165352 A JPS57165352 A JP S57165352A
Authority
JP
Japan
Prior art keywords
carnitine
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP57041794A
Other languages
English (en)
Inventor
Fuioriini Mario
Barenchiini Kuraujio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anic SpA
Original Assignee
Anic SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic SpA filed Critical Anic SpA
Publication of JPS57165352A publication Critical patent/JPS57165352A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C07C29/103—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57041794A 1981-03-18 1982-03-18 Manufacture of l-carnitine Pending JPS57165352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20396/81A IT1136945B (it) 1981-03-18 1981-03-18 Processo per la preparazione di l-carnitina

Publications (1)

Publication Number Publication Date
JPS57165352A true JPS57165352A (en) 1982-10-12

Family

ID=11166332

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57041794A Pending JPS57165352A (en) 1981-03-18 1982-03-18 Manufacture of l-carnitine

Country Status (4)

Country Link
US (1) US4413142A (ja)
EP (1) EP0060595A3 (ja)
JP (1) JPS57165352A (ja)
IT (1) IT1136945B (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008056827A1 (en) 2006-11-09 2008-05-15 Mitsubishi Rayon Co., Ltd. Process for production of betaine
JP2008133198A (ja) * 2006-11-27 2008-06-12 Mitsubishi Rayon Co Ltd Ｌ−カルニチンの製造方法
WO2008108466A1 (ja) 2007-03-07 2008-09-12 Mitsubishi Rayon Co., Ltd. 改良型ハロヒドリンエポキシダーゼ

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
US4575558A (en) * 1984-02-15 1986-03-11 American Hospital Supply Corporation Preparation of optically active 1,3-dioxolane-4-methanol compounds
DE3419723A1 (de) * 1984-05-26 1985-11-28 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von carnitinnitrilchlorid
CA1338723C (en) * 1985-11-25 1996-11-19 Hideyuki Takahashi Process for preparing 3-chloro-1,2-propanediol
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
JPS63251098A (ja) * 1987-04-07 1988-10-18 Kanegafuchi Chem Ind Co Ltd （ｒ）−３−ハロゲノ−１，２−プロパンジオ−ルの製造法
JPH0678277B2 (ja) * 1988-02-19 1994-10-05 高砂香料工業株式会社 光学活性アルコールおよびその誘導体の製造方法
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
IT1306162B1 (it) * 1999-06-30 2001-05-30 Sigma Tau Ind Farmaceuti Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
CN101823974A (zh) * 2010-05-20 2010-09-08 北京科技大学 一种以(r)-(-)-氯代甘油为手性起始原料合成l-肉碱的制备方法
CN113698320A (zh) * 2021-09-23 2021-11-26 抚顺顺能化工有限公司 一种l-卡内腈的制备方法
US20240228429A1 (en) * 2023-01-04 2024-07-11 Hubei Xujie Pharmaceutical Co., Ltd Process for producing l-carnitine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS3621718B1 (ja) * 1957-12-14 1961-11-11
US3151149A (en) * 1959-01-31 1964-09-29 Berlin Chemie Veb Production of pure d-and l-carnitinenitrile-chloride
JPS375171B1 (ja) * 1959-09-28 1962-06-19
FR1281230A (fr) * 1959-11-21 1962-01-12 Belge Produits Chimiques Sa Procédé de préparation de la carnitine
US3468937A (en) * 1965-07-13 1969-09-23 Berlin Chemie Veb Process for the preparation of pure carnitine in betaine form
US4296242A (en) * 1979-06-06 1981-10-20 Schering Corporation Process for the preparation of chiral 3-amino-2-hydroxypropionic acid and N-blocked derivatives thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008056827A1 (en) 2006-11-09 2008-05-15 Mitsubishi Rayon Co., Ltd. Process for production of betaine
US8334132B2 (en) 2006-11-09 2012-12-18 Mitsubishi Rayon Co., Ltd. Process for production of a betaine such as carnitine
JP2008133198A (ja) * 2006-11-27 2008-06-12 Mitsubishi Rayon Co Ltd Ｌ−カルニチンの製造方法
WO2008108466A1 (ja) 2007-03-07 2008-09-12 Mitsubishi Rayon Co., Ltd. 改良型ハロヒドリンエポキシダーゼ
EP2518152A2 (en) 2007-03-07 2012-10-31 Mitsubishi Rayon Co., Ltd. Improved halohydrin epoxidase
US8637272B2 (en) 2007-03-07 2014-01-28 Mitsubishi Rayon Co., Ltd. Halohydrin epoxidase

Also Published As

Publication number Publication date
IT8120396A0 (it) 1981-03-18
IT1136945B (it) 1986-09-03
US4413142A (en) 1983-11-01
EP0060595A3 (en) 1982-12-08
EP0060595A2 (en) 1982-09-22

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