JPS57145849A - Novel n-hydroxy-alkylated dicarboxylic acid-bis-(3,5-dicarbamoyl-2,4,6-triiodo- anilide), manufacture and contrast agent containing same - Google Patents
Novel n-hydroxy-alkylated dicarboxylic acid-bis-(3,5-dicarbamoyl-2,4,6-triiodo- anilide), manufacture and contrast agent containing sameInfo
- Publication number
- JPS57145849A JPS57145849A JP56126061A JP12606181A JPS57145849A JP S57145849 A JPS57145849 A JP S57145849A JP 56126061 A JP56126061 A JP 56126061A JP 12606181 A JP12606181 A JP 12606181A JP S57145849 A JPS57145849 A JP S57145849A
- Authority
- JP
- Japan
- Prior art keywords
- novel
- dicarbamoyl
- hydroxy
- dicarboxylic acid
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002872 contrast media Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940039231 contrast media Drugs 0.000 abstract 1
- 150000001990 dicarboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Photoreceptors In Electrophotography (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803038853 DE3038853A1 (de) | 1980-10-10 | 1980-10-10 | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57145849A true JPS57145849A (en) | 1982-09-09 |
| JPH0222066B2 JPH0222066B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-17 |
Family
ID=6114382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56126061A Granted JPS57145849A (en) | 1980-10-10 | 1981-08-13 | Novel n-hydroxy-alkylated dicarboxylic acid-bis-(3,5-dicarbamoyl-2,4,6-triiodo- anilide), manufacture and contrast agent containing same |
Country Status (14)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011509943A (ja) * | 2008-01-14 | 2011-03-31 | マリンクロッド・インコーポレイテッド | イオシメノールを調製するためのプロセス |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU88639I2 (fr) * | 1982-11-08 | 1996-02-01 | Nycomed Imaging S A | Agents de contraste pour rayons x |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| FR2541272A1 (fr) * | 1983-02-23 | 1984-08-24 | Guerbet Sa | Composes bromes et produits opacifiants en contenant |
| DE3731542A1 (de) * | 1987-09-17 | 1989-03-30 | Schering Ag | Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
| DE3739098A1 (de) * | 1987-11-16 | 1989-05-24 | Schering Ag | Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
| GB8906130D0 (en) * | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
| GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| WO1993010078A1 (es) * | 1991-11-18 | 1993-05-27 | Centro Investigacion Justesa Imagen S.A. | Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
| JPH07501809A (ja) * | 1991-12-03 | 1995-02-23 | マリンクロッド・メディカル・インコーポレイテッド | 非イオン性ｘ線造影剤組成物およびその製造方法 |
| FR2687669B1 (fr) * | 1992-02-24 | 1997-12-19 | Guerbet Sa | Composes utilisables dans des produits de contraste pour la radiographie. |
| WO1994005337A1 (en) * | 1992-09-02 | 1994-03-17 | Mallinckrodt Medical, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| WO1995026331A1 (es) * | 1994-03-25 | 1995-10-05 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones farmaceuticas que los contienen |
| WO2002051301A2 (en) | 2000-11-10 | 2002-07-04 | Wm. Marsh Rice University | Fullerene (c60)-based x-ray contrast agent for diagnostic imaging |
| DK1836239T3 (da) | 2005-01-13 | 2009-01-19 | Cinv Ag | Kompositmaterialer, der indeholder carbonnanopartikler |
| AU2008273037B2 (en) | 2007-07-12 | 2012-11-15 | Ge Healthcare As | Contrast agents |
| WO2009047318A1 (en) | 2007-10-12 | 2009-04-16 | Ge Healthcare As | Contrast agents |
| US20100221191A1 (en) | 2007-10-12 | 2010-09-02 | Duncan George Wynn | Contrast agents |
| EP2200656B1 (en) | 2007-10-12 | 2012-12-05 | GE Healthcare AS | Contrast agents |
| ES2413160T3 (es) | 2007-10-12 | 2013-07-15 | Ge Healthcare As | Agentes de contraste |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| WO2016079330A1 (en) | 2014-11-21 | 2016-05-26 | Technical University Of Denmark | Gel formulations for local drug release |
| JP7086863B2 (ja) | 2016-05-20 | 2022-06-20 | テクニカル ユニバーシティ オブ デンマーク | 触診可能なマーカー組成物 |
| WO2020249801A1 (en) | 2019-06-12 | 2020-12-17 | Technical University Of Denmark | Dissacharide formulations for controlled drug release |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4988834A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-12-22 | 1974-08-24 | ||
| JPS537637A (en) * | 1976-06-23 | 1978-01-24 | Schering Ag | Production of novel dicarboxylic aciddbis*3*55dicarbamoyll2*4*66 triiodo anilide* and xxray contrast medium containing same * production of tetraacarboxylic acid tetrachloride |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5147702B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-06-27 | 1976-12-16 | ||
| US4021481A (en) | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
| CH608189A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1491129A (en) | 1975-06-04 | 1977-11-09 | Guerbet Sa | Iodo-benzene derivatives and an x-ray contrast medium containing them |
| GB1548594A (en) | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| CH626873A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1977-03-28 | 1981-12-15 | Bracco Ind Chimica Spa | |
| US4230845A (en) | 1978-08-31 | 1980-10-28 | Mallinckrodt, Inc. | Polyhydroxy-alkyl-3,5-disubstituted-2,4,6-triiodocarbanilates |
| DE2852094A1 (de) * | 1978-11-30 | 1980-06-12 | Schering Ag | Neue roentgenkontrastmittel |
| DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| DE2928417A1 (de) | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
-
1980
- 1980-10-10 DE DE19803038853 patent/DE3038853A1/de not_active Withdrawn
-
1981
- 1981-07-07 DK DK300281A patent/DK158468C/da not_active IP Right Cessation
- 1981-07-31 IL IL63480A patent/IL63480A/xx not_active IP Right Cessation
- 1981-08-07 AT AT81106183T patent/ATE10488T1/de not_active IP Right Cessation
- 1981-08-07 EP EP81106183A patent/EP0049745B1/de not_active Expired
- 1981-08-07 DE DE8181106183T patent/DE3167463D1/de not_active Expired
- 1981-08-11 GR GR65764A patent/GR75308B/el unknown
- 1981-08-11 AU AU73978/81A patent/AU545934B2/en not_active Ceased
- 1981-08-12 IE IE1841/81A patent/IE51495B1/en not_active IP Right Cessation
- 1981-08-12 US US06/292,115 patent/US4426371A/en not_active Expired - Lifetime
- 1981-08-12 ES ES504701A patent/ES8205757A1/es not_active Expired
- 1981-08-12 CA CA000383725A patent/CA1186333A/en not_active Expired
- 1981-08-13 NO NO812753A patent/NO154550C/no unknown
- 1981-08-13 JP JP56126061A patent/JPS57145849A/ja active Granted
- 1981-08-13 PH PH26047A patent/PH18855A/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4988834A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-12-22 | 1974-08-24 | ||
| JPS537637A (en) * | 1976-06-23 | 1978-01-24 | Schering Ag | Production of novel dicarboxylic aciddbis*3*55dicarbamoyll2*4*66 triiodo anilide* and xxray contrast medium containing same * production of tetraacarboxylic acid tetrachloride |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011509943A (ja) * | 2008-01-14 | 2011-03-31 | マリンクロッド・インコーポレイテッド | イオシメノールを調製するためのプロセス |
Also Published As
| Publication number | Publication date |
|---|---|
| IE51495B1 (en) | 1987-01-07 |
| ES504701A0 (es) | 1982-08-16 |
| GR75308B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-07-13 |
| NO154550B (no) | 1986-07-07 |
| JPH0222066B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-17 |
| US4426371A (en) | 1984-01-17 |
| DE3038853A1 (de) | 1982-05-27 |
| PH18855A (en) | 1985-10-21 |
| EP0049745A1 (de) | 1982-04-21 |
| DK158468C (da) | 1990-10-08 |
| IL63480A0 (en) | 1981-10-30 |
| IL63480A (en) | 1984-03-30 |
| DK158468B (da) | 1990-05-21 |
| CA1186333A (en) | 1985-04-30 |
| NO154550C (no) | 1986-10-15 |
| ES8205757A1 (es) | 1982-08-16 |
| DE3167463D1 (en) | 1985-01-10 |
| AU545934B2 (en) | 1985-08-08 |
| DK300281A (da) | 1982-04-11 |
| ATE10488T1 (de) | 1984-12-15 |
| AU7397881A (en) | 1982-04-22 |
| EP0049745B1 (de) | 1984-11-28 |
| IE811841L (en) | 1982-05-10 |
| NO812753L (no) | 1982-04-13 |
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