ES8205757A1 - Procedimiento para la preparacion de bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas)de acidos dicarboxilicos,hidroxialcohi-ladas en n - Google Patents

Procedimiento para la preparacion de bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas)de acidos dicarboxilicos,hidroxialcohi-ladas en n

Info

Publication number
ES8205757A1
ES8205757A1 ES504701A ES504701A ES8205757A1 ES 8205757 A1 ES8205757 A1 ES 8205757A1 ES 504701 A ES504701 A ES 504701A ES 504701 A ES504701 A ES 504701A ES 8205757 A1 ES8205757 A1 ES 8205757A1
Authority
ES
Spain
Prior art keywords
dicarbamoyl
hydroxyalkylated
ray contrast
triiodo
anilides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504701A
Other languages
English (en)
Other versions
ES504701A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8205757A1 publication Critical patent/ES8205757A1/es
Publication of ES504701A0 publication Critical patent/ES504701A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BIS(3,5-DICARBAMOIL-2,4,6-TRIYODOANILIDAS) DE ACIDOS DICARBOXILICOS HIDROXIALCOHILADAS EN N, DE FORMULA (I), EN LA QUE R1, R2Y R3 PUEDEN SER VARIOS RADICALES Y X ES UN ENLACE DIRECTO O UN ALCOHILENO. CONSISTE EN LA REACCION DE HIDROXIALCOHILACION EN N DE UNA BIS (3,5-DICARBAMOIL-2,4,6-TRIYODO-ANILIDA) DE ACIDO DICARBOXILICO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LA QUE A ES HIDROGENO O CH2OH, B ES HIDROXI Y D ES CLORO, BROMO, SULFATO O ALCOHILSULFATO, O B Y D SON CONJUNTAMENTE EL ATOMO DE OXIGENO DE UN ANILLO OXIDO Y R1 R2 Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ALCOHOLATO O HIDRURO DE METAL ALCALINO A UNA TEMPERATURA ENTRE LA AMBIENTE Y 80C.
ES504701A 1980-10-10 1981-08-12 Procedimiento para la preparacion de bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas)de acidos dicarboxilicos,hidroxialcohi-ladas en n Granted ES504701A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803038853 DE3038853A1 (de) 1980-10-10 1980-10-10 Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)

Publications (2)

Publication Number Publication Date
ES8205757A1 true ES8205757A1 (es) 1982-08-16
ES504701A0 ES504701A0 (es) 1982-08-16

Family

ID=6114382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504701A Granted ES504701A0 (es) 1980-10-10 1981-08-12 Procedimiento para la preparacion de bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas)de acidos dicarboxilicos,hidroxialcohi-ladas en n

Country Status (14)

Country Link
US (1) US4426371A (es)
EP (1) EP0049745B1 (es)
JP (1) JPS57145849A (es)
AT (1) ATE10488T1 (es)
AU (1) AU545934B2 (es)
CA (1) CA1186333A (es)
DE (2) DE3038853A1 (es)
DK (1) DK158468C (es)
ES (1) ES504701A0 (es)
GR (1) GR75308B (es)
IE (1) IE51495B1 (es)
IL (1) IL63480A (es)
NO (1) NO154550C (es)
PH (1) PH18855A (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108638B1 (en) * 1982-11-08 1986-07-16 NYEGAARD & CO. A/S X-ray contrast agents
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
WO1993010078A1 (es) * 1991-11-18 1993-05-27 Centro Investigacion Justesa Imagen S.A. Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
JPH07501809A (ja) * 1991-12-03 1995-02-23 マリンクロッド・メディカル・インコーポレイテッド 非イオン性ｘ線造影剤組成物およびその製造方法
FR2687669B1 (fr) * 1992-02-24 1997-12-19 Guerbet Sa Composes utilisables dans des produits de contraste pour la radiographie.
WO1994005337A1 (en) * 1992-09-02 1994-03-17 Mallinckrodt Medical, Inc. Nonionic x-ray contrast agents, compositions and methods
WO1995026331A1 (es) * 1994-03-25 1995-10-05 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones farmaceuticas que los contienen
AU2002245169A1 (en) 2000-11-10 2002-07-08 Wm. Marsh Rice University Fullerene (c60)-based x-ray contrast agent for diagnostic imaging
EA011516B1 (ru) 2005-01-13 2009-04-28 Синвеншен Аг Композиционный материал и способ его изготовления
ES2486296T3 (es) 2007-07-12 2014-08-18 Ge Healthcare As Agentes de contraste
EP2200656B1 (en) 2007-10-12 2012-12-05 GE Healthcare AS Contrast agents
EP2200655B1 (en) 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
CN101821231A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
US20100221191A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
US8445725B2 (en) * 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN115501172A (zh) 2014-11-21 2022-12-23 丹麦技术大学 用于局部药物释放的凝胶制剂
MX2018014087A (es) 2016-05-20 2019-06-10 Univ Denmark Tech Dtu Composicion de marcaje palpable.
CA3143104A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL34803A (en) 1969-06-27 1975-03-13 Nyegaard & Co As N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them
US4021481A (en) 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
DD104193A5 (es) * 1972-12-22 1974-03-05
CH608189A5 (es) * 1974-12-13 1978-12-29 Savac Ag
GB1491129A (en) 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
GB1548594A (en) 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
CH626873A5 (es) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
US4230845A (en) 1978-08-31 1980-10-28 Mallinckrodt, Inc. Polyhydroxy-alkyl-3,5-disubstituted-2,4,6-triiodocarbanilates
DE2852094A1 (de) * 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
DE2928417A1 (de) 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono

Also Published As

Publication number Publication date
IL63480A0 (en) 1981-10-30
AU545934B2 (en) 1985-08-08
ATE10488T1 (de) 1984-12-15
AU7397881A (en) 1982-04-22
IE51495B1 (en) 1987-01-07
IL63480A (en) 1984-03-30
JPH0222066B2 (es) 1990-05-17
GR75308B (es) 1984-07-13
NO154550C (no) 1986-10-15
DE3038853A1 (de) 1982-05-27
DE3167463D1 (en) 1985-01-10
JPS57145849A (en) 1982-09-09
DK158468C (da) 1990-10-08
EP0049745B1 (de) 1984-11-28
EP0049745A1 (de) 1982-04-21
US4426371A (en) 1984-01-17
DK158468B (da) 1990-05-21
ES504701A0 (es) 1982-08-16
DK300281A (da) 1982-04-11
CA1186333A (en) 1985-04-30
NO812753L (no) 1982-04-13
IE811841L (en) 1982-05-10
PH18855A (en) 1985-10-21
NO154550B (no) 1986-07-07

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