JPS57143326A - Polymer linked to cellular toxic substance and its preparation - Google Patents

Polymer linked to cellular toxic substance and its preparation

Info

Publication number
JPS57143326A
JPS57143326A JP2934281A JP2934281A JPS57143326A JP S57143326 A JPS57143326 A JP S57143326A JP 2934281 A JP2934281 A JP 2934281A JP 2934281 A JP2934281 A JP 2934281A JP S57143326 A JPS57143326 A JP S57143326A
Authority
JP
Japan
Prior art keywords
polymer
toxic substance
units
cellular toxic
constituent units
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2934281A
Other languages
Japanese (ja)
Inventor
Yoshinori Kato
Hisashi Fukushima
Masahiko Saito
Naoji Umemoto
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP2934281A priority Critical patent/JPS57143326A/en
Publication of JPS57143326A publication Critical patent/JPS57143326A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

PURPOSE: To obtain the titled polymer, having improved absorption in the body and transfer to the target organs with reduced side effects, and usable as an antitumor agent, by reacting a polymer having specific constituent units with a cellular toxic substance containing amino and imino group.
CONSTITUTION: A polymer consisting of 60mol% or more constituent units of formulaI(Z is H or monovalent cation; m is an integer 1W4), e.g. p-[N,N-bis(2- chloroethyl)]phenylenediamine, in a solvent, e.g. dimethylformamide, while activating the carboxyl group of the polymer with 1-ethyl-3-(3-dimethylaminopropane)carbodiimide hydrochloride, to give the aimed polymer having 60mol% or more total constituent units of formulasIand II (Y is a reaction residue of amino and imino groups in the cellular toxic substance) and the ratio between the number of the units of formula II and the total number of units of formulasIand II of 0.05W0.95.
COPYRIGHT: (C)1982,JPO&Japio
JP2934281A 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation Pending JPS57143326A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2934281A JPS57143326A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2934281A JPS57143326A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Publications (1)

Publication Number Publication Date
JPS57143326A true JPS57143326A (en) 1982-09-04

Family

ID=12273552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2934281A Pending JPS57143326A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Country Status (1)

Country Link
JP (1) JPS57143326A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51126281A (en) * 1975-02-04 1976-11-04 Searle & Co Cytootoxic substance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51126281A (en) * 1975-02-04 1976-11-04 Searle & Co Cytootoxic substance

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