JPS57143325A - Polymer linked to cellular toxic substance and its preparation - Google Patents

Polymer linked to cellular toxic substance and its preparation

Info

Publication number
JPS57143325A
JPS57143325A JP2934181A JP2934181A JPS57143325A JP S57143325 A JPS57143325 A JP S57143325A JP 2934181 A JP2934181 A JP 2934181A JP 2934181 A JP2934181 A JP 2934181A JP S57143325 A JPS57143325 A JP S57143325A
Authority
JP
Japan
Prior art keywords
polymer
toxic substance
constituent units
formula
units
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2934181A
Other languages
Japanese (ja)
Inventor
Yoshinori Kato
Hisashi Fukushima
Masahiko Saito
Naoji Umemoto
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP2934181A priority Critical patent/JPS57143325A/en
Publication of JPS57143325A publication Critical patent/JPS57143325A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

PURPOSE: To obtain the titled polymer, having improved absorption in the body and transfer to the taret organs, with reduced side effects, and usable as an antitumor agent, by reacting a polymer consisting of specific constituent units with a cellular toxic substance having amino and imino groups.
CONSTITUTION: A polymer consisting of constituent units of formulaI(m is an integer 1W4; n is an integer 1W6) is reacted with an oxidizing agent, e.g. NaIO4, in a solbent, e.g. dimethylformamide, to give a polymer of formula II, which is then reacted with a cellular toxic substance, e.g. 1-(β-D-arabinofuranosyl)cytosine, and a reducing agent, e.g. NaCNBH3, in a solvent to afford the aimed polymer having the constituent units of formula III having 60mol, preferably 80mol% or more, total constituent units of formulaIand constituent units of formula IV (Y is a reaction residue of amino and imino groups of the cellular toxic substance) and the ratio between the number of the units of formula IV and the total number of the units of formulasIand IV is 0.05W0.95.
COPYRIGHT: (C)1982,JPO&Japio
JP2934181A 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation Pending JPS57143325A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2934181A JPS57143325A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2934181A JPS57143325A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Publications (1)

Publication Number Publication Date
JPS57143325A true JPS57143325A (en) 1982-09-04

Family

ID=12273525

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2934181A Pending JPS57143325A (en) 1981-03-03 1981-03-03 Polymer linked to cellular toxic substance and its preparation

Country Status (1)

Country Link
JP (1) JPS57143325A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62275128A (en) * 1986-02-14 1987-11-30 Nippon Mejifuijitsukusu Kk Reactive high-molecular compound having amino group and bifunctional ligand and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62275128A (en) * 1986-02-14 1987-11-30 Nippon Mejifuijitsukusu Kk Reactive high-molecular compound having amino group and bifunctional ligand and use thereof

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