JPS57140796A - 2'-deoxy-5-fluorouridine derivative and its preparation - Google Patents
2'-deoxy-5-fluorouridine derivative and its preparationInfo
- Publication number
- JPS57140796A JPS57140796A JP20993981A JP20993981A JPS57140796A JP S57140796 A JPS57140796 A JP S57140796A JP 20993981 A JP20993981 A JP 20993981A JP 20993981 A JP20993981 A JP 20993981A JP S57140796 A JPS57140796 A JP S57140796A
- Authority
- JP
- Japan
- Prior art keywords
- deoxy
- preparation
- acetyl
- halogen
- fluorouridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The compound of formulaI(R is H, 1W5C alkyl, 1W4C alkoxy, acetyloxy, or halogen; n is 1W3).
EXAMPLE: 2'-Deoxy-3',5'-di-0-acetyl-5-fluoro-3-(2-methylbenzoyl)uridine.
USE: Antitumor agent administrable parenterally or crally.
PROCESS: The objective compound is prepared by reacting (A) 1mol of 2'-deoxy- 3',5'-di-0-acetyl-5-fluorouridine with (B) 1W3mol of a benzoyl halide of formula II (Hal is halogen), e.g. 2-methylbenzoyl chloride, preferably in the presence of an aromatic amine such as triethylamine, in an aprotic solvent such as dioxane.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20993981A JPS57140796A (en) | 1981-12-28 | 1981-12-28 | 2'-deoxy-5-fluorouridine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20993981A JPS57140796A (en) | 1981-12-28 | 1981-12-28 | 2'-deoxy-5-fluorouridine derivative and its preparation |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10895578A Division JPS5535057A (en) | 1978-09-05 | 1978-09-05 | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57140796A true JPS57140796A (en) | 1982-08-31 |
Family
ID=16581160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20993981A Pending JPS57140796A (en) | 1981-12-28 | 1981-12-28 | 2'-deoxy-5-fluorouridine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57140796A (en) |
-
1981
- 1981-12-28 JP JP20993981A patent/JPS57140796A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES527954A1 (en) | Isoxazoles, useful as antiviral agents, and preparation thereof. | |
JPS5368752A (en) | 4-n-acyl fortimicin b derivatives and their preparation | |
CA2012686A1 (en) | Treatment and compounds | |
KR860009023A (en) | Process for preparing a novel ether compound having a substituted silyl group | |
JPS5535057A (en) | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it | |
JPS5791997A (en) | 5'-o-acylnucleoside and its preparation | |
CA2073567A1 (en) | Spicamycin derivatives and the use thereof | |
JPS56115799A (en) | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same | |
KR830007512A (en) | Method for producing short acting β-blocker | |
JPS57165387A (en) | Prparation of fluoran derivative | |
JPS57140796A (en) | 2'-deoxy-5-fluorouridine derivative and its preparation | |
JPS5724399A (en) | Novel nucleoside derivative | |
JPS5636645A (en) | Gelatin hardening method | |
ES2092962A1 (en) | Nitric esters of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid derivatives and their preparation process | |
EP0083204A3 (en) | 2-aminophenol derivatives and process for their preparation | |
JPS5419919A (en) | Novel phosphoric acid amide, its preparation, and flame-retardants consisting of the compound | |
IE821315L (en) | PREPARATION OF 5,6,7,7a-TETRAHYDRO-4H-THIENO-£3,2-c|¹PYRIDIN-2-ONES | |
FI913722A0 (en) | FREQUENCY REQUIREMENT FOR DEOXYNUCLEOSIDER. | |
JPS57126481A (en) | Aminopyrimidine derivative, fungicide, insecticide, and acaricide | |
JPS5716852A (en) | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same | |
JPS55118494A (en) | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it | |
JPS55130949A (en) | Novel phenylacetamide derivative | |
JPS57197256A (en) | Novel cyclohexanecarboxamide derivative and its preparation | |
JPS5735596A (en) | Ester derivative of deoxyfluorouridine | |
JPS57108075A (en) | Hydrazinopyridazine compound |