JPS57123152A - Novel aminobenzoic acid derivative and drug composition - Google Patents
Novel aminobenzoic acid derivative and drug compositionInfo
- Publication number
- JPS57123152A JPS57123152A JP898681A JP898681A JPS57123152A JP S57123152 A JPS57123152 A JP S57123152A JP 898681 A JP898681 A JP 898681A JP 898681 A JP898681 A JP 898681A JP S57123152 A JPS57123152 A JP S57123152A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- compound
- drug composition
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A compound shown by the formula I(R1 is H, halogen; R2 and R3 are H, or lower alkoxy; with the proviso that both R2 and R3 are not H simultaneously) and its salt.
EXAMPLE: N-(2-Carboxy-4,5-dimethoxyphenyl)-4-chloroanthranilic acid.
USE: A remedy for peptic ulcer, an improver for liver function, an improver for kidney function, and remedy for diseases resulting from immune function incompetence. Useful for remedying rhemumathritis, autoimmune disease, cancer, microbism, asthma, etc.
PROCESS: A compound shown by the formula II (X is halogen) is reacted with a compound shown by the formula III, to give a compound shown by the formula I. The reaction is carried out in a solvent such as DMSO, DMA, etc., the addition of a catalytic amount of an alakali metal such as K2CO3, NaCO3, etc. and a metal compound such as metal copper powder, etc. and a catalytic amount of an iodine compound improve the yield extremely. The amount of the compound shown by the formula Iin the drug composition is about 0.5W3,000mg (oral medication type)/day.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP898681A JPS57123152A (en) | 1981-01-26 | 1981-01-26 | Novel aminobenzoic acid derivative and drug composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP898681A JPS57123152A (en) | 1981-01-26 | 1981-01-26 | Novel aminobenzoic acid derivative and drug composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57123152A true JPS57123152A (en) | 1982-07-31 |
Family
ID=11708005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP898681A Pending JPS57123152A (en) | 1981-01-26 | 1981-01-26 | Novel aminobenzoic acid derivative and drug composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57123152A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172530A (en) * | 2013-04-12 | 2013-06-26 | 沈阳三九药业有限公司 | Preparation method of tolfenamic acid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212141A (en) * | 1975-06-11 | 1977-01-29 | Chugai Pharmaceut Co Ltd | Novel amino benzoic acid derivatives, their preparation, and pharmaceu tical compositions therefrom |
| JPS5337857A (en) * | 1976-09-20 | 1978-04-07 | Matsushita Electric Ind Co Ltd | Composite hybrid integrated circuit |
-
1981
- 1981-01-26 JP JP898681A patent/JPS57123152A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212141A (en) * | 1975-06-11 | 1977-01-29 | Chugai Pharmaceut Co Ltd | Novel amino benzoic acid derivatives, their preparation, and pharmaceu tical compositions therefrom |
| JPS5337857A (en) * | 1976-09-20 | 1978-04-07 | Matsushita Electric Ind Co Ltd | Composite hybrid integrated circuit |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172530A (en) * | 2013-04-12 | 2013-06-26 | 沈阳三九药业有限公司 | Preparation method of tolfenamic acid |
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