JPS5711917A - Suppository containing sephalosporin - Google Patents

Suppository containing sephalosporin

Info

Publication number
JPS5711917A
JPS5711917A JP8547380A JP8547380A JPS5711917A JP S5711917 A JPS5711917 A JP S5711917A JP 8547380 A JP8547380 A JP 8547380A JP 8547380 A JP8547380 A JP 8547380A JP S5711917 A JPS5711917 A JP S5711917A
Authority
JP
Japan
Prior art keywords
water
organic acid
soluble organic
soluble salt
sephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8547380A
Other languages
Japanese (ja)
Other versions
JPH0118882B2 (en
Inventor
Sadao Hirota
Masami Morita
Yasuaki Osada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP8547380A priority Critical patent/JPS5711917A/en
Publication of JPS5711917A publication Critical patent/JPS5711917A/en
Publication of JPH0118882B2 publication Critical patent/JPH0118882B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: A suppository that is made by adding a water-soluble organic acid and its water-soluble salt to a sephalosporin antibiotic and its water-soluble salt, thus reducing the damage in the mucous tissues of the rectum and improving the absorption of the active principle in the rectal administration.
CONSTITUTION: The objective suppository includes a compound of the formula [R1 is 2-(2-thienyl)acethyl; R2 is H, methoxy; R3 is lower alkyl] such as cefoxitin or cephamethazol and their water-soluble salt as the major ingredients and a water- soluble organic acid such as succinic or citric acid and their salts, further preferably a nonionic surfactant such as polyoxyethylene higher alcohol ether. The water-soluble organic acid keeps the pH in the rectum to 3.5W5.5 and permits the absorption of the active ingredient equalt to or more than in the intravenous injection. The amount of the active principle is preferably 50W1,000, preferably 100W500mg every one supporsitory.
COPYRIGHT: (C)1982,JPO&Japio
JP8547380A 1980-06-24 1980-06-24 Suppository containing sephalosporin Granted JPS5711917A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8547380A JPS5711917A (en) 1980-06-24 1980-06-24 Suppository containing sephalosporin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8547380A JPS5711917A (en) 1980-06-24 1980-06-24 Suppository containing sephalosporin

Publications (2)

Publication Number Publication Date
JPS5711917A true JPS5711917A (en) 1982-01-21
JPH0118882B2 JPH0118882B2 (en) 1989-04-07

Family

ID=13859868

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8547380A Granted JPS5711917A (en) 1980-06-24 1980-06-24 Suppository containing sephalosporin

Country Status (1)

Country Link
JP (1) JPS5711917A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082221A (en) * 1973-11-08 1975-07-03
JPS5191290A (en) * 1975-01-02 1976-08-10

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082221A (en) * 1973-11-08 1975-07-03
JPS5191290A (en) * 1975-01-02 1976-08-10

Also Published As

Publication number Publication date
JPH0118882B2 (en) 1989-04-07

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