JPS5711917A - Suppository containing sephalosporin - Google Patents
Suppository containing sephalosporinInfo
- Publication number
- JPS5711917A JPS5711917A JP8547380A JP8547380A JPS5711917A JP S5711917 A JPS5711917 A JP S5711917A JP 8547380 A JP8547380 A JP 8547380A JP 8547380 A JP8547380 A JP 8547380A JP S5711917 A JPS5711917 A JP S5711917A
- Authority
- JP
- Japan
- Prior art keywords
- water
- organic acid
- soluble organic
- soluble salt
- sephalosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: A suppository that is made by adding a water-soluble organic acid and its water-soluble salt to a sephalosporin antibiotic and its water-soluble salt, thus reducing the damage in the mucous tissues of the rectum and improving the absorption of the active principle in the rectal administration.
CONSTITUTION: The objective suppository includes a compound of the formula [R1 is 2-(2-thienyl)acethyl; R2 is H, methoxy; R3 is lower alkyl] such as cefoxitin or cephamethazol and their water-soluble salt as the major ingredients and a water- soluble organic acid such as succinic or citric acid and their salts, further preferably a nonionic surfactant such as polyoxyethylene higher alcohol ether. The water-soluble organic acid keeps the pH in the rectum to 3.5W5.5 and permits the absorption of the active ingredient equalt to or more than in the intravenous injection. The amount of the active principle is preferably 50W1,000, preferably 100W500mg every one supporsitory.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8547380A JPS5711917A (en) | 1980-06-24 | 1980-06-24 | Suppository containing sephalosporin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8547380A JPS5711917A (en) | 1980-06-24 | 1980-06-24 | Suppository containing sephalosporin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5711917A true JPS5711917A (en) | 1982-01-21 |
JPH0118882B2 JPH0118882B2 (en) | 1989-04-07 |
Family
ID=13859868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8547380A Granted JPS5711917A (en) | 1980-06-24 | 1980-06-24 | Suppository containing sephalosporin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5711917A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5082221A (en) * | 1973-11-08 | 1975-07-03 | ||
JPS5191290A (en) * | 1975-01-02 | 1976-08-10 |
-
1980
- 1980-06-24 JP JP8547380A patent/JPS5711917A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5082221A (en) * | 1973-11-08 | 1975-07-03 | ||
JPS5191290A (en) * | 1975-01-02 | 1976-08-10 |
Also Published As
Publication number | Publication date |
---|---|
JPH0118882B2 (en) | 1989-04-07 |
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