JPS5686121A - Antitumor proten complex and its preparation - Google Patents
Antitumor proten complex and its preparationInfo
- Publication number
- JPS5686121A JPS5686121A JP16160979A JP16160979A JPS5686121A JP S5686121 A JPS5686121 A JP S5686121A JP 16160979 A JP16160979 A JP 16160979A JP 16160979 A JP16160979 A JP 16160979A JP S5686121 A JPS5686121 A JP S5686121A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor
- fragment
- practically
- component consisting
- diphtheria toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 6
- 239000012634 fragment Substances 0.000 abstract 5
- 102000016607 Diphtheria Toxin Human genes 0.000 abstract 4
- 108010053187 Diphtheria Toxin Proteins 0.000 abstract 4
- 108060003951 Immunoglobulin Proteins 0.000 abstract 4
- 102000018358 immunoglobulin Human genes 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 101000972324 Cynodon dactylon Leaf protein Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16160979A JPS5686121A (en) | 1979-12-14 | 1979-12-14 | Antitumor proten complex and its preparation |
| DE8080304352T DE3067584D1 (en) | 1979-12-14 | 1980-12-03 | Antitumor protein hybrid and process for the preparation thereof |
| EP80304352A EP0031999B1 (en) | 1979-12-14 | 1980-12-03 | Antitumor protein hybrid and process for the preparation thereof |
| US06/216,709 US4379145A (en) | 1979-12-14 | 1980-12-15 | Antitumor protein hybrid and process for the preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16160979A JPS5686121A (en) | 1979-12-14 | 1979-12-14 | Antitumor proten complex and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5686121A true JPS5686121A (en) | 1981-07-13 |
| JPS6221000B2 JPS6221000B2 (enExample) | 1987-05-11 |
Family
ID=15738406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16160979A Granted JPS5686121A (en) | 1979-12-14 | 1979-12-14 | Antitumor proten complex and its preparation |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4379145A (enExample) |
| EP (1) | EP0031999B1 (enExample) |
| JP (1) | JPS5686121A (enExample) |
| DE (1) | DE3067584D1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6067434A (ja) * | 1983-09-24 | 1985-04-17 | Mitsubishi Chem Ind Ltd | 抗腫瘍剤 |
| JPS6069033A (ja) * | 1983-06-21 | 1985-04-19 | ザ・ボ−ド・オブ・リ−ジエンツ・ザ・ユニバ−シテイ・オブ・テキサス・システム | 免疫毒素複合体 |
| JPS6112630A (ja) * | 1984-06-20 | 1986-01-21 | サノフイ | 免疫毒素およびその製造法 |
| US7083957B2 (en) | 2001-02-12 | 2006-08-01 | Reasearch Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US7101977B2 (en) | 2001-07-17 | 2006-09-05 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8102194L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
| SE8102193L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och dess anvendning |
| IT1203672B (it) * | 1982-05-12 | 1989-02-15 | Harvard College | Proteina ibrida comprendente frammenti proteici collegati da legami peptidici e relativo gene di fusione composizione contenente tale proteina |
| US4487715A (en) * | 1982-07-09 | 1984-12-11 | The Regents Of The University Of California | Method of conjugating oligopeptides |
| JPS59116232A (ja) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | 細胞毒性複合体及びその製造法 |
| GB2148299B (en) * | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| US4894443A (en) * | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| EP0170697B1 (en) * | 1984-02-08 | 1991-10-23 | Cetus Oncology Corporation | Toxin conjugates |
| US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US4698420A (en) * | 1985-02-25 | 1987-10-06 | Xoma Corporation | Antibody hybrid molecules and process for their preparation |
| US4888415A (en) * | 1985-03-04 | 1989-12-19 | Dana-Farber Cancer Institute, Inc. | Gelonin immunotoxin |
| WO1986005098A1 (en) * | 1985-03-04 | 1986-09-12 | Dana-Farber Cancer Institute, Inc. | Immunotoxin and method of making |
| US5055291A (en) * | 1986-11-04 | 1991-10-08 | Baylor College Of Medicine | Compositions for preventing secondary cataracts |
| US4871350A (en) * | 1986-11-04 | 1989-10-03 | Baylor College Of Medicine | Methods and compositions for preventing secondary cataracts |
| US5827934A (en) * | 1988-03-08 | 1998-10-27 | The University Of Wyoming | Cytotoxic diphtheria toxin fragments |
| US5171563A (en) * | 1988-09-30 | 1992-12-15 | Neorx Corporation | Cleavable linkers for the reduction of non-target organ retention of immunoconjugates |
| GB9114399D0 (en) * | 1991-07-03 | 1991-08-21 | Ici Plc | Conjugates |
| US5690935A (en) * | 1995-01-13 | 1997-11-25 | Regents Of The University Of Minnesota | Biotherapy of cancer by targeting TP-3/P80 |
| US6050943A (en) | 1997-10-14 | 2000-04-18 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
| US7914453B2 (en) | 2000-12-28 | 2011-03-29 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
| KR101062525B1 (ko) * | 2002-11-12 | 2011-09-06 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 포도상구균 감염에 대한 다당류 백신 |
| US7824348B2 (en) | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
| US9011336B2 (en) * | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
| US7393325B2 (en) | 2004-09-16 | 2008-07-01 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment with a multi-directional transducer |
| US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
| US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
| US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
| US20120165848A1 (en) | 2010-08-02 | 2012-06-28 | Guided Therapy Systems, Llc | System and method for treating cartilage |
| US7530958B2 (en) * | 2004-09-24 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for combined ultrasound treatment |
| US7530356B2 (en) * | 2004-10-06 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for noninvasive mastopexy |
| US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
| US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
| US7758524B2 (en) | 2004-10-06 | 2010-07-20 | Guided Therapy Systems, L.L.C. | Method and system for ultra-high frequency ultrasound treatment |
| JP5094402B2 (ja) | 2004-10-06 | 2012-12-12 | ガイデッド セラピー システムズ， エル．エル．シー． | 超音波組織処理ための方法およびシステム |
| US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
| EP1879502A2 (en) | 2004-10-06 | 2008-01-23 | Guided Therapy Systems, L.L.C. | Method and system for cosmetic enhancement |
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| EP2533130A1 (en) | 2005-04-25 | 2012-12-12 | Ardent Sound, Inc. | Method and system for enhancing computer peripheral saftey |
| US9566454B2 (en) * | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
| EP2152351B1 (en) * | 2007-05-07 | 2016-09-21 | Guided Therapy Systems, L.L.C. | Methods and systems for modulating medicants using acoustic energy |
| US20150174388A1 (en) | 2007-05-07 | 2015-06-25 | Guided Therapy Systems, Llc | Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| KR102087909B1 (ko) | 2008-06-06 | 2020-03-12 | 얼테라, 인크 | 코스메틱 치료 시스템 |
| US12102473B2 (en) | 2008-06-06 | 2024-10-01 | Ulthera, Inc. | Systems for ultrasound treatment |
| JP5555230B2 (ja) | 2008-07-21 | 2014-07-23 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | β−１，６−グルコサミンオリゴ糖を合成するための方法および組成物 |
| CA2748362A1 (en) | 2008-12-24 | 2010-07-01 | Michael H. Slayton | Methods and systems for fat reduction and/or cellulite treatment |
| JP5851842B2 (ja) | 2009-01-12 | 2016-02-03 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | 改変した抗体組成物、それを作製および使用する方法 |
| WO2010096838A2 (en) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Llc | Proproteins and methods of use thereof |
| US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
| US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
| US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
| KR102068728B1 (ko) | 2011-07-10 | 2020-01-21 | 가이디드 테라피 시스템스, 엘.엘.씨. | 초음파 치료를 위한 방법 및 시스템 |
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| US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
| US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
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| US20170028227A1 (en) | 2014-04-18 | 2017-02-02 | Ulthera, Inc. | Band transducer ultrasound therapy |
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| TWI883390B (zh) | 2018-01-26 | 2025-05-11 | 美商奧賽拉公司 | 用於多個維度中的同時多聚焦超音治療的系統和方法 |
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| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2862449D1 (en) * | 1977-08-22 | 1984-11-22 | Nat Res Dev | Macromolecular covalent conjugates, methods for preparing and pharmaceutical compositions containing them |
| JPS55136235A (en) * | 1979-04-09 | 1980-10-23 | Teijin Ltd | Antitumor protein complex and its preparation |
| JPS5616417A (en) * | 1979-07-19 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
| JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
-
1979
- 1979-12-14 JP JP16160979A patent/JPS5686121A/ja active Granted
-
1980
- 1980-12-03 EP EP80304352A patent/EP0031999B1/en not_active Expired
- 1980-12-03 DE DE8080304352T patent/DE3067584D1/de not_active Expired
- 1980-12-15 US US06/216,709 patent/US4379145A/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6069033A (ja) * | 1983-06-21 | 1985-04-19 | ザ・ボ−ド・オブ・リ−ジエンツ・ザ・ユニバ−シテイ・オブ・テキサス・システム | 免疫毒素複合体 |
| JPS6067434A (ja) * | 1983-09-24 | 1985-04-17 | Mitsubishi Chem Ind Ltd | 抗腫瘍剤 |
| JPS6112630A (ja) * | 1984-06-20 | 1986-01-21 | サノフイ | 免疫毒素およびその製造法 |
| US7083957B2 (en) | 2001-02-12 | 2006-08-01 | Reasearch Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US7285635B2 (en) | 2001-02-12 | 2007-10-23 | Research Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US7741278B2 (en) | 2001-02-12 | 2010-06-22 | Research Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US7943571B2 (en) | 2001-02-12 | 2011-05-17 | Research Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US8138311B2 (en) | 2001-02-12 | 2012-03-20 | Research Development Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US7101977B2 (en) | 2001-07-17 | 2006-09-05 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
| US7371723B2 (en) | 2001-07-17 | 2008-05-13 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
| US7759091B2 (en) | 2001-07-17 | 2010-07-20 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
| US8043831B2 (en) | 2001-07-17 | 2011-10-25 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0031999A3 (en) | 1981-07-29 |
| DE3067584D1 (en) | 1984-05-24 |
| US4379145A (en) | 1983-04-05 |
| EP0031999B1 (en) | 1984-04-18 |
| JPS6221000B2 (enExample) | 1987-05-11 |
| EP0031999A2 (en) | 1981-07-15 |
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