JPS568378A - Dibenzo b,f thiepin derivative and its preparation - Google Patents

Dibenzo b,f thiepin derivative and its preparation

Info

Publication number
JPS568378A
JPS568378A JP8519279A JP8519279A JPS568378A JP S568378 A JPS568378 A JP S568378A JP 8519279 A JP8519279 A JP 8519279A JP 8519279 A JP8519279 A JP 8519279A JP S568378 A JPS568378 A JP S568378A
Authority
JP
Japan
Prior art keywords
dibenzo
formula
compound
thiepin
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8519279A
Other languages
Japanese (ja)
Inventor
Michio Tsutsui
Takao Watanabe
Yoshio Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP8519279A priority Critical patent/JPS568378A/en
Publication of JPS568378A publication Critical patent/JPS568378A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A dibenzo[b,f]thiepin derivative of formula I (R1 is lower alkylene group; R2 and R3 are lower alkyl groups; R4 is H etc.; X is halogen).
EXAMPLE: 2-Hydroxy-8-chloro-10-( 2-dimethylaminoethoxy )-dibenzo[b,f]-thiepin and 2-hydroxy-8-chloro-dibenzo[b,f]thiepin-10(11H)-one.
USE: A medicine having a central nervous system suppressant action.
PROCESS: A compound of formula II (Z is hydroxy-protecting group) is reacted with a reactive derivative of a compound of formula III, e.g. an ester or salt with hydrochloric, sulfuric or methanesulfonic acid, in the presence of a basic condensing agent, e.g. an alkali metal such as Li or Na, to give a compound of formula IV, which is then subjected to elimination of the hydroxyprotecting group if necessary, to form the compound of formula I wherein R4 is H.
COPYRIGHT: (C)1981,JPO&Japio
JP8519279A 1979-07-04 1979-07-04 Dibenzo b,f thiepin derivative and its preparation Pending JPS568378A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8519279A JPS568378A (en) 1979-07-04 1979-07-04 Dibenzo b,f thiepin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8519279A JPS568378A (en) 1979-07-04 1979-07-04 Dibenzo b,f thiepin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS568378A true JPS568378A (en) 1981-01-28

Family

ID=13851781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8519279A Pending JPS568378A (en) 1979-07-04 1979-07-04 Dibenzo b,f thiepin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS568378A (en)

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