JPS5673091A - Manufacture of 33aminoo11hydroxypropanee1*11 diphosphoric acid - Google Patents

Manufacture of 33aminoo11hydroxypropanee1*11 diphosphoric acid

Info

Publication number
JPS5673091A
JPS5673091A JP14948780A JP14948780A JPS5673091A JP S5673091 A JPS5673091 A JP S5673091A JP 14948780 A JP14948780 A JP 14948780A JP 14948780 A JP14948780 A JP 14948780A JP S5673091 A JPS5673091 A JP S5673091A
Authority
JP
Japan
Prior art keywords
group
beta
alanine
manufacture
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14948780A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6318951B2 (OSRAM
Inventor
Buruumu Herumuuto
Haintsu Buorumusu Kaaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6084548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5673091(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of JPS5673091A publication Critical patent/JPS5673091A/ja
Publication of JPS6318951B2 publication Critical patent/JPS6318951B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
JP14948780A 1979-10-27 1980-10-27 Manufacture of 33aminoo11hydroxypropanee1*11 diphosphoric acid Granted JPS5673091A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2943498A DE2943498C2 (de) 1979-10-27 1979-10-27 Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure

Publications (2)

Publication Number Publication Date
JPS5673091A true JPS5673091A (en) 1981-06-17
JPS6318951B2 JPS6318951B2 (OSRAM) 1988-04-20

Family

ID=6084548

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14948780A Granted JPS5673091A (en) 1979-10-27 1980-10-27 Manufacture of 33aminoo11hydroxypropanee1*11 diphosphoric acid

Country Status (5)

Country Link
US (1) US4327039A (OSRAM)
EP (1) EP0027982B2 (OSRAM)
JP (1) JPS5673091A (OSRAM)
AT (1) ATE1242T1 (OSRAM)
DE (1) DE2943498C2 (OSRAM)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure
US4446052A (en) * 1982-05-17 1984-05-01 The Procter & Gamble Company Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
DE3334211A1 (de) * 1983-09-22 1985-04-04 Henkel KGaA, 4000 Düsseldorf Dihydroxyalkandiphosphonsaeuren
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5139786A (en) * 1989-07-07 1992-08-18 Ciba-Geigy Corporation Topical formulations
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5349026A (en) * 1992-11-20 1994-09-20 Rohm And Haas Company Reactive coalescents
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
KR100192215B1 (ko) * 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
PE20011065A1 (es) 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
MXPA04006027A (es) * 2001-12-21 2004-09-27 Procter & Gamble Metodo para el tratamiento de trastornos de los huesos.
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
DE60317061T2 (de) * 2002-05-10 2008-07-24 F. Hoffmann-La Roche Ag Ibandronsäure zur behandlung und vorbeugung von osteoporose
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
EP1596870B2 (en) * 2002-12-20 2011-04-06 F. Hoffmann-La Roche AG High dose ibandronate formulation
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
EP1653913B1 (en) * 2003-08-12 2012-05-23 3M Innovative Properties Company Self-etching dental compositions and methods
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN101018534B (zh) * 2004-07-08 2012-07-04 3M创新有限公司 牙科的方法，组合物，和包括酸敏感染料的试剂盒
ATE526006T1 (de) * 2004-08-11 2011-10-15 3M Innovative Properties Co Selbstklebende zusammensetzungen mit einer vielzahl von sauren verbindungen
KR20070092972A (ko) * 2004-12-10 2007-09-14 테무릭크 가부시키가이샤 전이암 치료제 및 암 전이 억제제
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP1984430A2 (de) 2006-02-03 2008-10-29 Universität Stuttgart - Institut für Chemische Verfahrenstechnik Phosphonsäure-haltige blends und phosphonsäure-haltige polymere
WO2008076739A2 (en) * 2006-12-13 2008-06-26 3M Innovative Properties Company Methods of using a dental composition having an acidic component and a photobleachable dye
CN102670628B (zh) * 2008-01-25 2015-11-25 奇默里克斯公司 治疗病毒感染的方法
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
EP2462152A4 (en) 2009-08-03 2013-02-13 Chimerix Inc COMPOSITION AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS AND TEMPORED VIRUSES
HUE032860T2 (en) 2010-02-12 2017-11-28 Chimerix Inc A method for treating a virus infection
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361528A (en) * 1964-09-08 1968-01-02 Monsanto Co Purification of orthophosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2658961C3 (de) * 1976-12-24 1981-09-24 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Hydroxy-3-amino-propan-1,1-diphosphonsäuren
DE2702631A1 (de) 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren

Also Published As

Publication number Publication date
EP0027982A1 (de) 1981-05-06
ATE1242T1 (de) 1982-07-15
US4327039A (en) 1982-04-27
JPS6318951B2 (OSRAM) 1988-04-20
DE2943498A1 (de) 1981-05-07
DE2943498C2 (de) 1983-01-27
EP0027982B1 (de) 1982-06-23
EP0027982B2 (de) 1987-09-16

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