JPS5673085A - Preparation of mitomycin - Google Patents
Preparation of mitomycinInfo
- Publication number
- JPS5673085A JPS5673085A JP14956479A JP14956479A JPS5673085A JP S5673085 A JPS5673085 A JP S5673085A JP 14956479 A JP14956479 A JP 14956479A JP 14956479 A JP14956479 A JP 14956479A JP S5673085 A JPS5673085 A JP S5673085A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- ammonia
- amine
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound useful as an antimicrobial agent per se or a synthetic intermediate for the well-known antitumor mitomycin derivatives readily, by reacting a specific compound with ammonia or an amine.
CONSTITUTION: A compound of formula I (R1 is alkyl or substituted or unsubstituted aryl; Z is alkyl or acyl) is reacted with ammonia or an amine of formula II (R2 and R3 are H, alkyl or substituted or unsubstituted aryl) in a solvent, e.g. methanol, at 0W80°C for several minutes to one week. After the reaction, the titled compound of formula III is obtained from the reaction solution by the conventional method, e.g. column chromatography. The molar amount of the ammonia or amine is 1W100 times that of the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14956479A JPS5673085A (en) | 1979-11-20 | 1979-11-20 | Preparation of mitomycin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14956479A JPS5673085A (en) | 1979-11-20 | 1979-11-20 | Preparation of mitomycin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5673085A true JPS5673085A (en) | 1981-06-17 |
Family
ID=15477926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14956479A Pending JPS5673085A (en) | 1979-11-20 | 1979-11-20 | Preparation of mitomycin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5673085A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4771068A (en) * | 1985-04-10 | 1988-09-13 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives having anti-tumor and antibacterial utility |
-
1979
- 1979-11-20 JP JP14956479A patent/JPS5673085A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4771068A (en) * | 1985-04-10 | 1988-09-13 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives having anti-tumor and antibacterial utility |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS56131565A (en) | 4-substituted-2-oxoazetidine compound and its preparation | |
JPS56125347A (en) | Preparation of dipeptide | |
JPS5673085A (en) | Preparation of mitomycin | |
EP0080570A3 (en) | Ailanthone derivatives | |
JPS57120600A (en) | Nitrosourea derivative and its preparation | |
MY110725A (en) | Process for preparing crystalline b-lactam monohydrate | |
JPS579754A (en) | Preparation of methylene dicarbanilate | |
JPS57139065A (en) | Preparation of omega-indole-3-ylalkanole compound | |
JPS5770847A (en) | Preparation of 3-aminoglutaric acid dialkyl ester | |
JPS5551079A (en) | Preparation of benzoxazole derivative | |
JPS51113882A (en) | Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives | |
JPS54109943A (en) | Preparation of phenylglycine derivative | |
JPS5555160A (en) | Preparation of substituted benzamide | |
JPS55124760A (en) | Preparation of 1,4-dihydropyridine derivative or its salt | |
JPS55153790A (en) | Preparation of 7-amino-3-heterocyclic thiomethyl-delta3- cephem-4-carboxylic acid | |
JPS5753486A (en) | Preparation of 3-formyl-pyrazolo 1,5-a pyridine derivative | |
JPS55133384A (en) | Preparation of rifamycin derivative | |
JPS5271478A (en) | Synthesis of novel derivatives of kanamycin b | |
JPS5718667A (en) | Preparation of aporphine compound | |
JPS5545608A (en) | Preparation of organosilver compound | |
JPS5668668A (en) | Preparation of 2-indolinones | |
JPS5788154A (en) | Preparation of beta-aminoacrolein | |
JPS5589286A (en) | Novel preparation of 3-hydrazonomethylrifamycins | |
JPS5278886A (en) | Synthesis of 5-fluorouracil derivatives | |
JPS5616487A (en) | Preparation of rifamycin derivative |