JPS5673085A - Preparation of mitomycin - Google Patents

Preparation of mitomycin

Info

Publication number
JPS5673085A
JPS5673085A JP14956479A JP14956479A JPS5673085A JP S5673085 A JPS5673085 A JP S5673085A JP 14956479 A JP14956479 A JP 14956479A JP 14956479 A JP14956479 A JP 14956479A JP S5673085 A JPS5673085 A JP S5673085A
Authority
JP
Japan
Prior art keywords
formula
compound
ammonia
amine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14956479A
Other languages
Japanese (ja)
Inventor
Yutaka Saito
Kimikatsu Shirahata
Masaji Kasai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP14956479A priority Critical patent/JPS5673085A/en
Publication of JPS5673085A publication Critical patent/JPS5673085A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an antimicrobial agent per se or a synthetic intermediate for the well-known antitumor mitomycin derivatives readily, by reacting a specific compound with ammonia or an amine.
CONSTITUTION: A compound of formula I (R1 is alkyl or substituted or unsubstituted aryl; Z is alkyl or acyl) is reacted with ammonia or an amine of formula II (R2 and R3 are H, alkyl or substituted or unsubstituted aryl) in a solvent, e.g. methanol, at 0W80°C for several minutes to one week. After the reaction, the titled compound of formula III is obtained from the reaction solution by the conventional method, e.g. column chromatography. The molar amount of the ammonia or amine is 1W100 times that of the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP14956479A 1979-11-20 1979-11-20 Preparation of mitomycin Pending JPS5673085A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14956479A JPS5673085A (en) 1979-11-20 1979-11-20 Preparation of mitomycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14956479A JPS5673085A (en) 1979-11-20 1979-11-20 Preparation of mitomycin

Publications (1)

Publication Number Publication Date
JPS5673085A true JPS5673085A (en) 1981-06-17

Family

ID=15477926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14956479A Pending JPS5673085A (en) 1979-11-20 1979-11-20 Preparation of mitomycin

Country Status (1)

Country Link
JP (1) JPS5673085A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility

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