JPS5671099A - 20-deoxodesmycosin - Google Patents

20-deoxodesmycosin

Info

Publication number
JPS5671099A
JPS5671099A JP14664279A JP14664279A JPS5671099A JP S5671099 A JPS5671099 A JP S5671099A JP 14664279 A JP14664279 A JP 14664279A JP 14664279 A JP14664279 A JP 14664279A JP S5671099 A JPS5671099 A JP S5671099A
Authority
JP
Japan
Prior art keywords
group
remedy
converted
reduced
deoxodesmycosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14664279A
Other languages
Japanese (ja)
Other versions
JPS6159637B2 (en
Inventor
Hideo Sakakibara
Tatsuro Fujiwara
Susumu Watanabe
Tetsuo Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP14664279A priority Critical patent/JPS5671099A/en
Priority to NL8004922A priority patent/NL8004922A/en
Priority to DE19803033032 priority patent/DE3033032A1/en
Priority to US06/184,375 priority patent/US4345069A/en
Priority to GB8029019A priority patent/GB2058765B/en
Priority to CA000360427A priority patent/CA1192542A/en
Priority to FR8019987A priority patent/FR2465747A1/en
Priority to IT24738/80A priority patent/IT1141057B/en
Priority to CH699780A priority patent/CH645650A5/en
Priority to ES495214A priority patent/ES495214A0/en
Publication of JPS5671099A publication Critical patent/JPS5671099A/en
Priority to ES503606A priority patent/ES8300117A1/en
Publication of JPS6159637B2 publication Critical patent/JPS6159637B2/ja
Granted legal-status Critical Current

Links

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  • Fodder In General (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:20-Deoxodesmycosin (20-deoxo-4'-demycarosyltylosin) or its salt.
USE: Having strong antibacterial activity against Gram-positive bacterial, a remedy for infectious diseases, a remedy for animals, and food additive.
PROCESS: A CHO group at 19 position of tylosin is reduced in such mild conditions preferably as it is not reduced a CO group at 9 position so that the CHO group is converted into CH2OH group. The OH of CH2OH group at 19 position is tosylated with p-toluenesulfonyl halide in the presence of preferably a tertiary amine. p- Toluenesulfonate is removed in reductive manners with NaI and Zn, converted into a CH3 group to give a compound shown by the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP14664279A 1979-09-19 1979-11-13 20-deoxodesmycosin Granted JPS5671099A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP14664279A JPS5671099A (en) 1979-11-13 1979-11-13 20-deoxodesmycosin
NL8004922A NL8004922A (en) 1979-09-19 1980-08-29 DEFORMYLTYLOSINE DERIVATIVES.
DE19803033032 DE3033032A1 (en) 1979-09-19 1980-09-02 DEFORMYLTYLOSIN DERIVATIVES
US06/184,375 US4345069A (en) 1979-09-19 1980-09-05 Deformyltylosin derivatives
GB8029019A GB2058765B (en) 1979-09-19 1980-09-09 Deformyltylosin derivatives
CA000360427A CA1192542A (en) 1979-09-19 1980-09-17 Deformyltylosin derivatives
FR8019987A FR2465747A1 (en) 1979-09-19 1980-09-17 DEFORMYLTYLOSINE DERIVATIVES USEFUL AS ANTIBIOTICS
IT24738/80A IT1141057B (en) 1979-09-19 1980-09-18 DEFORMYLTYLOSINE DERIVATIVES AND THEIR PREPARATION
CH699780A CH645650A5 (en) 1979-09-19 1980-09-18 DEFORMYLTYLOSIN DERIVATIVES.
ES495214A ES495214A0 (en) 1979-09-19 1980-09-19 PROCEDURE FOR OBTAINING NEW DEFOR-MILTYLOSINO DERIVATIVES
ES503606A ES8300117A1 (en) 1979-09-19 1981-07-01 Deformyltylosin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14664279A JPS5671099A (en) 1979-11-13 1979-11-13 20-deoxodesmycosin

Publications (2)

Publication Number Publication Date
JPS5671099A true JPS5671099A (en) 1981-06-13
JPS6159637B2 JPS6159637B2 (en) 1986-12-17

Family

ID=15412334

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14664279A Granted JPS5671099A (en) 1979-09-19 1979-11-13 20-deoxodesmycosin

Country Status (1)

Country Link
JP (1) JPS5671099A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973599A (en) * 1982-09-13 1984-04-25 イーライ・リリー・アンド・カンバニー C-20-modified macrolide derivative
JPS59167598A (en) * 1983-02-28 1984-09-21 イーライ・リリー・アンド・カンパニー C-20- and c-23-modified macrolide derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973599A (en) * 1982-09-13 1984-04-25 イーライ・リリー・アンド・カンバニー C-20-modified macrolide derivative
JPH0517240B2 (en) * 1982-09-13 1993-03-08 Lilly Co Eli
JPS59167598A (en) * 1983-02-28 1984-09-21 イーライ・リリー・アンド・カンパニー C-20- and c-23-modified macrolide derivatives

Also Published As

Publication number Publication date
JPS6159637B2 (en) 1986-12-17

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