GB1522717A - Derivatives of substituted n-alkyl imidazoles having pharmaceutical activity - Google Patents

Derivatives of substituted n-alkyl imidazoles having pharmaceutical activity

Info

Publication number
GB1522717A
GB1522717A GB30685/76A GB3068576A GB1522717A GB 1522717 A GB1522717 A GB 1522717A GB 30685/76 A GB30685/76 A GB 30685/76A GB 3068576 A GB3068576 A GB 3068576A GB 1522717 A GB1522717 A GB 1522717A
Authority
GB
United Kingdom
Prior art keywords
substituted
phenyl
derivatives
pharmaceutical activity
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30685/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of GB1522717A publication Critical patent/GB1522717A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Abstract

The compounds correspond to the formula: <IMAGE> in which R<1> and R<2> denote phenyl, phenyl-lower alkyl or phenyl-lower alkenyl and the phenyl rings can be alkyl-, halogen- or trifluoromethyl-substituted, X represents oxygen or sulphur and n = 1 to 8. They are prepared by etherification of corresponding compounds of the formula: <IMAGE> in which A represents hydroxyl or a leaving group (Y), with a compound R<2>Y or R<2>OH or R<2>SH. The compounds and their salts are distinguished by fungicidal, antibacterial and antiprotozoal action; they can be used in the corresponding therapeutic indications.
GB30685/76A 1975-07-28 1976-07-22 Derivatives of substituted n-alkyl imidazoles having pharmaceutical activity Expired GB1522717A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59961875A 1975-07-28 1975-07-28
US66502376A 1976-03-08 1976-03-08

Publications (1)

Publication Number Publication Date
GB1522717A true GB1522717A (en) 1978-08-23

Family

ID=27083399

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30685/76A Expired GB1522717A (en) 1975-07-28 1976-07-22 Derivatives of substituted n-alkyl imidazoles having pharmaceutical activity

Country Status (14)

Country Link
JP (1) JPS6028820B2 (en)
AU (1) AU505298B2 (en)
CH (2) CH621117A5 (en)
DE (1) DE2633492A1 (en)
ES (2) ES461979A1 (en)
FR (1) FR2319348A1 (en)
GB (1) GB1522717A (en)
HK (1) HK8480A (en)
IE (1) IE43409B1 (en)
MX (1) MX3866E (en)
MY (1) MY8000271A (en)
NL (1) NL183760C (en)
NZ (1) NZ181567A (en)
PH (1) PH14563A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005980A2 (en) * 1978-05-30 1979-12-12 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles, their preparation and these compounds for pharmaceutical use
EP0013786A1 (en) * 1979-01-22 1980-08-06 Syntex (U.S.A.) Inc. Imidazole derivatives, pharmaceutical compositions containing them and their preparation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL184160C (en) * 1977-01-10 1989-05-01 Syntex Inc IMIDAZOLE DERIVATIVES, PREPARATIONS CONTAINING THEM, AND METHOD FOR THE PREPARATION THEREOF
DE2845254A1 (en) * 1978-10-18 1980-05-08 Basf Ag GAMMA AZOLYL COMPOUNDS
DE2912288A1 (en) * 1979-03-28 1980-10-09 Bayer Ag METHOD FOR PRODUCING HYDROXYETHYL AZOLES
JPS55160767A (en) * 1979-05-31 1980-12-13 Idota Yutaka Imidazole derivative
CA1155853A (en) * 1980-06-06 1983-10-25 Joseph A. Martin Imidazole derivatives and preparation thereof
DE3369984D1 (en) * 1982-07-12 1987-04-09 Searle & Co 1-(1h-imidazolyl), 1-n-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them
JPS6068220A (en) * 1983-09-24 1985-04-18 株式会社マキ製作所 Automatic mounting method and device for fruit cap
JPH0829011B2 (en) * 1987-11-16 1996-03-27 井関農機株式会社 Seedling transplanter
JPH03115267A (en) * 1989-09-28 1991-05-16 Maruho Kk Propiophenone derivative, its production and central muscle relaxant and antispasmodic agent containing the same
JP6229896B2 (en) * 2013-01-21 2017-11-15 国立大学法人大阪大学 Phenoxyalkylamine compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (en) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Method for preparing imidazole derivatives
US3658813A (en) * 1970-01-13 1972-04-25 Janssen Pharmaceutica Nv 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles
DE2041771C3 (en) * 1970-08-22 1979-07-26 Bayer Ag, 5090 Leverkusen derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005980A2 (en) * 1978-05-30 1979-12-12 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles, their preparation and these compounds for pharmaceutical use
EP0005980A3 (en) * 1978-05-30 1980-01-09 Syntex (U.S.A.) Inc. Derivatives of substituted n-alkyl imidazoles, their preparation and pharmaceutical use
EP0013786A1 (en) * 1979-01-22 1980-08-06 Syntex (U.S.A.) Inc. Imidazole derivatives, pharmaceutical compositions containing them and their preparation

Also Published As

Publication number Publication date
AU1622276A (en) 1978-02-02
HK8480A (en) 1980-03-14
CH623040A5 (en) 1981-05-15
DE2633492A1 (en) 1977-02-24
IE43409L (en) 1977-01-28
FR2319348B1 (en) 1979-07-13
JPS6028820B2 (en) 1985-07-06
FR2319348A1 (en) 1977-02-25
IE43409B1 (en) 1981-02-25
CH621117A5 (en) 1981-01-15
NZ181567A (en) 1978-04-28
DE2633492C2 (en) 1990-10-25
MX3866E (en) 1981-08-26
NL7608297A (en) 1977-02-01
MY8000271A (en) 1980-12-31
JPS5217472A (en) 1977-02-09
NL183760B (en) 1988-08-16
PH14563A (en) 1981-09-24
AU505298B2 (en) 1979-11-15
NL183760C (en) 1989-01-16
ES461980A1 (en) 1978-06-01
ES461979A1 (en) 1978-12-01

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960721