JPS5671095A - Preparation of cephalosphorin compound - Google Patents

Preparation of cephalosphorin compound

Info

Publication number
JPS5671095A
JPS5671095A JP14848679A JP14848679A JPS5671095A JP S5671095 A JPS5671095 A JP S5671095A JP 14848679 A JP14848679 A JP 14848679A JP 14848679 A JP14848679 A JP 14848679A JP S5671095 A JPS5671095 A JP S5671095A
Authority
JP
Japan
Prior art keywords
formula
compound shown
compound
reacting
cephalosphorin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14848679A
Other languages
Japanese (ja)
Other versions
JPS6210514B2 (en
Inventor
Masahiro Murakami
Masateru Kobayashi
Kimiyo Yamamoto
Kazuyuki Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP14848679A priority Critical patent/JPS5671095A/en
Priority to DE8080106952T priority patent/DE3062779D1/en
Priority to AT80106952T priority patent/ATE3044T1/en
Priority to EP19800106952 priority patent/EP0029202B1/en
Publication of JPS5671095A publication Critical patent/JPS5671095A/en
Publication of JPS6210514B2 publication Critical patent/JPS6210514B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound extremely safely, efficiently in high yield, useful as a wide range antibiotic, by reacting a 7-aminocephalospholanic acid derivative with a novel compound having high reactivity in mild conditions as an acylating agent.
CONSTITUTION: A compound shown by the formula I (R1 is halogen, azide, acetoxy, or benzimidazolethio) or its salt is reacted with a novel compound shown by the formula II (R2 is H, methyl carboxymethyl, or methyl sulfonate), to give a cephalosphorin compound shown by the formula III or its pharmaceutically accetable salt. The compound shown by the formula II is obtained in high yield by reacting a compound shown by the formula IV with mandelic acid. The reaction is carried out without severe temperature control and side reactions by the use of the compound shown by the formula II. Both reaction of acylation and substitution are carried out simultaneously under the same conditions to shorten the process extremely. It has improved workability and maintenance free from irritant action and hygroscopicity.
COPYRIGHT: (C)1981,JPO&Japio
JP14848679A 1979-11-16 1979-11-16 Preparation of cephalosphorin compound Granted JPS5671095A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP14848679A JPS5671095A (en) 1979-11-16 1979-11-16 Preparation of cephalosphorin compound
DE8080106952T DE3062779D1 (en) 1979-11-16 1980-11-11 Novel tetrazole-5-thiol esters and process for preparing cefamandole using same
AT80106952T ATE3044T1 (en) 1979-11-16 1980-11-11 TETRAZOLE-5-THIOL ESTER AND PROCESS USING THEM TO PRODUCTION CEPHAMANDOL.
EP19800106952 EP0029202B1 (en) 1979-11-16 1980-11-11 Novel tetrazole-5-thiol esters and process for preparing cefamandole using same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14848679A JPS5671095A (en) 1979-11-16 1979-11-16 Preparation of cephalosphorin compound

Publications (2)

Publication Number Publication Date
JPS5671095A true JPS5671095A (en) 1981-06-13
JPS6210514B2 JPS6210514B2 (en) 1987-03-06

Family

ID=15453825

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14848679A Granted JPS5671095A (en) 1979-11-16 1979-11-16 Preparation of cephalosphorin compound

Country Status (1)

Country Link
JP (1) JPS5671095A (en)

Also Published As

Publication number Publication date
JPS6210514B2 (en) 1987-03-06

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