JPS5665881A - Novel 1,2,4-oxadiazole derivative and its acid addition salt - Google Patents
Novel 1,2,4-oxadiazole derivative and its acid addition saltInfo
- Publication number
- JPS5665881A JPS5665881A JP14254079A JP14254079A JPS5665881A JP S5665881 A JPS5665881 A JP S5665881A JP 14254079 A JP14254079 A JP 14254079A JP 14254079 A JP14254079 A JP 14254079A JP S5665881 A JPS5665881 A JP S5665881A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- addition salt
- acid addition
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 1,2,4-oxadiazole derivative shown by the formula I [R1 is H, (halo)alkyl, alkenyl, alkoxy, cycloalkyl, pyridyl, a group shown by the formula II (R5 is H, halogen, alkyl, etc.; A1 is alkylene, carbonyl, etc.), etc.; R2 is H, halogen, nitro, amino, OH, mercapto, etc.; R3 is H, or alkyl; R4 is OH, (halo)alkoxy, amino, hydroxyamino, etc.] and its acid addition salt.
EXAMPLE: 3-[4-(α-Carboxyethyl)phenyl]-5-methyl-1,2,4-oxadiazole.
USE: A drug having anti-inglammatory action, pain killing and antypyretic action.
PROCESS: For example, a reactive derivative of a carboxylic acid shown by the formula R1COOH is reacted with a benzamidoxime derivative shown by the formula III to give o-acylamidoxime shown by the formula IV, which is condensed through dehydration, to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14254079A JPS5665881A (en) | 1979-11-01 | 1979-11-01 | Novel 1,2,4-oxadiazole derivative and its acid addition salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14254079A JPS5665881A (en) | 1979-11-01 | 1979-11-01 | Novel 1,2,4-oxadiazole derivative and its acid addition salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5665881A true JPS5665881A (en) | 1981-06-03 |
Family
ID=15317723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14254079A Pending JPS5665881A (en) | 1979-11-01 | 1979-11-01 | Novel 1,2,4-oxadiazole derivative and its acid addition salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5665881A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091726A2 (en) * | 1982-03-03 | 1983-10-19 | Sumitomo Chemical Company, Limited | 5-Substituted 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
| US9056843B2 (en) | 2011-07-08 | 2015-06-16 | Novartis Ag | Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| WO2016143654A1 (en) * | 2015-03-06 | 2016-09-15 | 旭硝子株式会社 | Production method for 1,2,4-oxadiazole derivative |
| CN109071522A (en) * | 2016-04-12 | 2018-12-21 | 先正达参股股份有限公司 | Kill the oxadiazole derivatives of microorganism |
| WO2019150219A2 (en) | 2018-01-30 | 2019-08-08 | Pi Industries Ltd. | Novel oxadiazoles |
| WO2019171234A1 (en) | 2018-03-09 | 2019-09-12 | Pi Industries Ltd. | Heterocyclic compounds as fungicides |
| WO2019219464A1 (en) | 2018-05-15 | 2019-11-21 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| WO2020070611A1 (en) | 2018-10-01 | 2020-04-09 | Pi Industries Ltd | Oxadiazoles as fungicides |
| WO2020070610A1 (en) | 2018-10-01 | 2020-04-09 | Pi Industries Ltd. | Novel oxadiazoles |
| US20200138027A1 (en) * | 2016-05-20 | 2020-05-07 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
-
1979
- 1979-11-01 JP JP14254079A patent/JPS5665881A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4618617A (en) * | 1982-03-03 | 1986-10-21 | Sumitomo Chemical Company, Limited | Novel 5-substituted 1,2,4,-oxadiazole derivatives and preparation thereof |
| EP0091726A2 (en) * | 1982-03-03 | 1983-10-19 | Sumitomo Chemical Company, Limited | 5-Substituted 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
| US9056843B2 (en) | 2011-07-08 | 2015-06-16 | Novartis Ag | Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| WO2016143654A1 (en) * | 2015-03-06 | 2016-09-15 | 旭硝子株式会社 | Production method for 1,2,4-oxadiazole derivative |
| CN109071522A (en) * | 2016-04-12 | 2018-12-21 | 先正达参股股份有限公司 | Kill the oxadiazole derivatives of microorganism |
| US20200138027A1 (en) * | 2016-05-20 | 2020-05-07 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| US11154060B2 (en) * | 2016-05-20 | 2021-10-26 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| WO2019150219A2 (en) | 2018-01-30 | 2019-08-08 | Pi Industries Ltd. | Novel oxadiazoles |
| US11286242B2 (en) | 2018-01-30 | 2022-03-29 | Pi Industries Ltd. | Oxadiazoles for use in controlling phytopathogenic fungi |
| WO2019171234A1 (en) | 2018-03-09 | 2019-09-12 | Pi Industries Ltd. | Heterocyclic compounds as fungicides |
| WO2019219464A1 (en) | 2018-05-15 | 2019-11-21 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| WO2020070610A1 (en) | 2018-10-01 | 2020-04-09 | Pi Industries Ltd. | Novel oxadiazoles |
| WO2020070611A1 (en) | 2018-10-01 | 2020-04-09 | Pi Industries Ltd | Oxadiazoles as fungicides |
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