JPS5665877A - Preparation of 4-quinazolone derivative - Google Patents

Preparation of 4-quinazolone derivative

Info

Publication number
JPS5665877A
JPS5665877A JP14198779A JP14198779A JPS5665877A JP S5665877 A JPS5665877 A JP S5665877A JP 14198779 A JP14198779 A JP 14198779A JP 14198779 A JP14198779 A JP 14198779A JP S5665877 A JPS5665877 A JP S5665877A
Authority
JP
Japan
Prior art keywords
formula
group
ring closure
amine
amino group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14198779A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP14198779A priority Critical patent/JPS5665877A/en
Priority to NZ192392A priority patent/NZ192392A/en
Priority to US06/103,841 priority patent/US4276295A/en
Priority to YU03063/79A priority patent/YU306379A/en
Priority to DE19792950376 priority patent/DE2950376A1/en
Priority to AR279316A priority patent/AR225028A1/en
Priority to SE7910376A priority patent/SE7910376L/en
Priority to AU53932/79A priority patent/AU526309B2/en
Priority to IT28062/79A priority patent/IT1126577B/en
Priority to NL7909118A priority patent/NL7909118A/en
Priority to DK539979A priority patent/DK539979A/en
Priority to NO794135A priority patent/NO794135L/en
Priority to GB7943565A priority patent/GB2040927B/en
Priority to ES487014A priority patent/ES8102102A1/en
Priority to CH1125779A priority patent/CH644112A5/en
Priority to DD79217854A priority patent/DD150462A5/en
Priority to FR7931059A priority patent/FR2444671A1/en
Priority to HU79II311A priority patent/HU182733B/en
Publication of JPS5665877A publication Critical patent/JPS5665877A/en
Pending legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain advantageously the titled compound being partly a novel compound useful as a vasodilator, etc., by formylating an amino group of a 2-carboxyaniline derivative, followed by ring closure in the presence of an amine or after converting a carboxyl group to carbodiimide group.
CONSTITUTION: An amino group of a compound shown by the formula I (R1 and R3 are lower alkyl; R2 is alkoxycarbonyl and R1WR3 are linked at 3W5 positions or 4W6 positions based on NH2) is formylated, and subjected to ring closure in the presence of an amine shown by the formula II [R4 is a group shown by the formula III or IV (R5WR7 are H or halogen; R6 is CF3, etc.; R7 is CN, etc.; R8 is H or lower alkyl], or subjected to ring closure after a carboxyl group shown by the formula I is converted to carbodiimide by the amine shown by the formula II and the amino group is formylated. The reaction product is optionally hydrolyzed to give advantageously a compound shown by the formula I being partly a novel compound useful as a vasodilator, improver for blood stream, antihypertensive agent or agent for arterioschlerosis.
COPYRIGHT: (C)1981,JPO&Japio
JP14198779A 1978-12-19 1979-11-05 Preparation of 4-quinazolone derivative Pending JPS5665877A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP14198779A JPS5665877A (en) 1979-11-05 1979-11-05 Preparation of 4-quinazolone derivative
NZ192392A NZ192392A (en) 1978-12-19 1979-12-13 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
US06/103,841 US4276295A (en) 1978-12-19 1979-12-14 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof
YU03063/79A YU306379A (en) 1978-12-19 1979-12-14 Process for producing 3-aromatically substituted 4(3h)-quinazolines
DE19792950376 DE2950376A1 (en) 1978-12-19 1979-12-14 4 (3H) -QUINAZOLINONES SUBSTITUTED IN A 3-POSITION WITH AROMATIC GROUP AND METHOD FOR THE PRODUCTION AND USE THEREOF
AR279316A AR225028A1 (en) 1978-12-19 1979-12-17 A PROCEDURE FOR PRODUCING A 4 (3H) -QUINAZOLINONE 3-PHENYL OR PIRIDIL-SUBSTITUTED
SE7910376A SE7910376L (en) 1978-12-19 1979-12-17 quinazolinone derivatives
AU53932/79A AU526309B2 (en) 1978-12-19 1979-12-17 Substituted quinazolinones
IT28062/79A IT1126577B (en) 1978-12-19 1979-12-17 4 (3H) -CHINAZOLINONES REPLACED IN THE 3-AROMATIC HALF, PROCEDURE FOR THEIR PRODUCTION AND USE
NL7909118A NL7909118A (en) 1978-12-19 1979-12-18 SUBSTITUTED CHINAZOLIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE COMPONENT.
DK539979A DK539979A (en) 1978-12-19 1979-12-18 QUINAZOLINO DERIVATIVES AND THEIR PREPARATION AND USE
NO794135A NO794135L (en) 1978-12-19 1979-12-18 SUBSTITUTED 4 (3H) CHINAZOLINONES, PROCEDURE FOR THE PREPARATION AND USE OF THESE
GB7943565A GB2040927B (en) 1978-12-19 1979-12-18 Pharmaceutically active 3 - aromatic moiety substituted - 4 (3h) - quinazolinone derivatives
ES487014A ES8102102A1 (en) 1978-12-19 1979-12-18 A procedure to obtain 4 (3h) -quinazolinones replaced with an aromatic rest in position 3. (Machine-translation by Google Translate, not legally binding)
CH1125779A CH644112A5 (en) 1978-12-19 1979-12-19 3-AROMATIC-SUBSTITUTED-4 (3H) CHINAZOLINONES AND METHOD FOR THE PRODUCTION THEREOF.
DD79217854A DD150462A5 (en) 1978-12-19 1979-12-19 PROCESS FOR PREPARING 4 (3H) -CHINAZOLINONES SUBSTITUTED IN 3-POSITION WITH AROMATIC GROUP
FR7931059A FR2444671A1 (en) 1978-12-19 1979-12-19 NEW QUINAZOLINONES, THEIR PREPARATION AND THE MEDICINE CONTAINING THESE SUBSTANCES
HU79II311A HU182733B (en) 1978-12-19 1979-12-19 Process for producing substituted quinazoline-derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14198779A JPS5665877A (en) 1979-11-05 1979-11-05 Preparation of 4-quinazolone derivative

Publications (1)

Publication Number Publication Date
JPS5665877A true JPS5665877A (en) 1981-06-03

Family

ID=15304752

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14198779A Pending JPS5665877A (en) 1978-12-19 1979-11-05 Preparation of 4-quinazolone derivative

Country Status (1)

Country Link
JP (1) JPS5665877A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative

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