JPS5665877A - Preparation of 4-quinazolone derivative - Google Patents
Preparation of 4-quinazolone derivativeInfo
- Publication number
- JPS5665877A JPS5665877A JP14198779A JP14198779A JPS5665877A JP S5665877 A JPS5665877 A JP S5665877A JP 14198779 A JP14198779 A JP 14198779A JP 14198779 A JP14198779 A JP 14198779A JP S5665877 A JPS5665877 A JP S5665877A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- ring closure
- amine
- amino group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain advantageously the titled compound being partly a novel compound useful as a vasodilator, etc., by formylating an amino group of a 2-carboxyaniline derivative, followed by ring closure in the presence of an amine or after converting a carboxyl group to carbodiimide group.
CONSTITUTION: An amino group of a compound shown by the formula I (R1 and R3 are lower alkyl; R2 is alkoxycarbonyl and R1WR3 are linked at 3W5 positions or 4W6 positions based on NH2) is formylated, and subjected to ring closure in the presence of an amine shown by the formula II [R4 is a group shown by the formula III or IV (R5WR7 are H or halogen; R6 is CF3, etc.; R7 is CN, etc.; R8 is H or lower alkyl], or subjected to ring closure after a carboxyl group shown by the formula I is converted to carbodiimide by the amine shown by the formula II and the amino group is formylated. The reaction product is optionally hydrolyzed to give advantageously a compound shown by the formula I being partly a novel compound useful as a vasodilator, improver for blood stream, antihypertensive agent or agent for arterioschlerosis.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14198779A JPS5665877A (en) | 1979-11-05 | 1979-11-05 | Preparation of 4-quinazolone derivative |
NZ192392A NZ192392A (en) | 1978-12-19 | 1979-12-13 | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
US06/103,841 US4276295A (en) | 1978-12-19 | 1979-12-14 | 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof |
YU03063/79A YU306379A (en) | 1978-12-19 | 1979-12-14 | Process for producing 3-aromatically substituted 4(3h)-quinazolines |
DE19792950376 DE2950376A1 (en) | 1978-12-19 | 1979-12-14 | 4 (3H) -QUINAZOLINONES SUBSTITUTED IN A 3-POSITION WITH AROMATIC GROUP AND METHOD FOR THE PRODUCTION AND USE THEREOF |
AR279316A AR225028A1 (en) | 1978-12-19 | 1979-12-17 | A PROCEDURE FOR PRODUCING A 4 (3H) -QUINAZOLINONE 3-PHENYL OR PIRIDIL-SUBSTITUTED |
SE7910376A SE7910376L (en) | 1978-12-19 | 1979-12-17 | quinazolinone derivatives |
AU53932/79A AU526309B2 (en) | 1978-12-19 | 1979-12-17 | Substituted quinazolinones |
IT28062/79A IT1126577B (en) | 1978-12-19 | 1979-12-17 | 4 (3H) -CHINAZOLINONES REPLACED IN THE 3-AROMATIC HALF, PROCEDURE FOR THEIR PRODUCTION AND USE |
NL7909118A NL7909118A (en) | 1978-12-19 | 1979-12-18 | SUBSTITUTED CHINAZOLIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE COMPONENT. |
DK539979A DK539979A (en) | 1978-12-19 | 1979-12-18 | QUINAZOLINO DERIVATIVES AND THEIR PREPARATION AND USE |
NO794135A NO794135L (en) | 1978-12-19 | 1979-12-18 | SUBSTITUTED 4 (3H) CHINAZOLINONES, PROCEDURE FOR THE PREPARATION AND USE OF THESE |
GB7943565A GB2040927B (en) | 1978-12-19 | 1979-12-18 | Pharmaceutically active 3 - aromatic moiety substituted - 4 (3h) - quinazolinone derivatives |
ES487014A ES8102102A1 (en) | 1978-12-19 | 1979-12-18 | A procedure to obtain 4 (3h) -quinazolinones replaced with an aromatic rest in position 3. (Machine-translation by Google Translate, not legally binding) |
CH1125779A CH644112A5 (en) | 1978-12-19 | 1979-12-19 | 3-AROMATIC-SUBSTITUTED-4 (3H) CHINAZOLINONES AND METHOD FOR THE PRODUCTION THEREOF. |
DD79217854A DD150462A5 (en) | 1978-12-19 | 1979-12-19 | PROCESS FOR PREPARING 4 (3H) -CHINAZOLINONES SUBSTITUTED IN 3-POSITION WITH AROMATIC GROUP |
FR7931059A FR2444671A1 (en) | 1978-12-19 | 1979-12-19 | NEW QUINAZOLINONES, THEIR PREPARATION AND THE MEDICINE CONTAINING THESE SUBSTANCES |
HU79II311A HU182733B (en) | 1978-12-19 | 1979-12-19 | Process for producing substituted quinazoline-derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14198779A JPS5665877A (en) | 1979-11-05 | 1979-11-05 | Preparation of 4-quinazolone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5665877A true JPS5665877A (en) | 1981-06-03 |
Family
ID=15304752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14198779A Pending JPS5665877A (en) | 1978-12-19 | 1979-11-05 | Preparation of 4-quinazolone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5665877A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008156358A (en) * | 2004-02-13 | 2008-07-10 | Banyu Pharmaceut Co Ltd | Fused ring 4-oxopyrimidine derivative |
-
1979
- 1979-11-05 JP JP14198779A patent/JPS5665877A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008156358A (en) * | 2004-02-13 | 2008-07-10 | Banyu Pharmaceut Co Ltd | Fused ring 4-oxopyrimidine derivative |
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