JPS5522606A - Preparation of 3-amino-2-hydroxy-4-p-hydroxyphenyl- butanoylleucine and its derivative - Google Patents

Preparation of 3-amino-2-hydroxy-4-p-hydroxyphenyl- butanoylleucine and its derivative

Info

Publication number
JPS5522606A
JPS5522606A JP8518578A JP8518578A JPS5522606A JP S5522606 A JPS5522606 A JP S5522606A JP 8518578 A JP8518578 A JP 8518578A JP 8518578 A JP8518578 A JP 8518578A JP S5522606 A JPS5522606 A JP S5522606A
Authority
JP
Japan
Prior art keywords
amino
hydroxy
derivative
protecting group
butanoylleucine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8518578A
Other languages
Japanese (ja)
Other versions
JPS6039264B2 (en
Inventor
Rinzo Nishizawa
Tetsuyuki Saino
Kenji Seya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP53085185A priority Critical patent/JPS6039264B2/en
Publication of JPS5522606A publication Critical patent/JPS5522606A/en
Publication of JPS6039264B2 publication Critical patent/JPS6039264B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To obtain the title compound which is an anticarcinogenic immunizing agent, etc., in high yield, by the diazotization of 3-amino-2-hydroxy-4-p- aminophenylbutanoylleucine derivative obtained from easily available bestatin, followed by the decomposition.
CONSTITUTION: 3-Amino-2-hydroxy-4-p-aminophenylbutanoylleucine derivative of formula I(R1 is H; R2 is amino-protecting group; R1 and R2 may form a phthalyl group; R3 is H or protecting group of COOH) is converted into diazonium salt by acting diazotizing agent on it. The title compound of formula II(R4 is H or amino- protecting group; R1 and R4 may form a phthalyl group; R5 is H or protecting group of COOH) is obtained by the decomposition of the diazonium salt. The compound I is produced from bestatin obtained by synthesis or fermentation.
COPYRIGHT: (C)1980,JPO&Japio
JP53085185A 1978-07-14 1978-07-14 Method for producing 3-amino-2-hydroxy-4-p-hydroxyphenylbutanoylleucine and its derivatives Expired JPS6039264B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53085185A JPS6039264B2 (en) 1978-07-14 1978-07-14 Method for producing 3-amino-2-hydroxy-4-p-hydroxyphenylbutanoylleucine and its derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53085185A JPS6039264B2 (en) 1978-07-14 1978-07-14 Method for producing 3-amino-2-hydroxy-4-p-hydroxyphenylbutanoylleucine and its derivatives

Publications (2)

Publication Number Publication Date
JPS5522606A true JPS5522606A (en) 1980-02-18
JPS6039264B2 JPS6039264B2 (en) 1985-09-05

Family

ID=13851594

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53085185A Expired JPS6039264B2 (en) 1978-07-14 1978-07-14 Method for producing 3-amino-2-hydroxy-4-p-hydroxyphenylbutanoylleucine and its derivatives

Country Status (1)

Country Link
JP (1) JPS6039264B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793253U (en) * 1980-11-29 1982-06-08
JPS63268910A (en) * 1987-04-24 1988-11-07 Mazda Motor Corp Exhaust purifier for engine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0216779A (en) * 1988-07-04 1990-01-19 Matsushita Electric Ind Co Ltd Light emitting diode type indicator

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793253U (en) * 1980-11-29 1982-06-08
JPS5938933Y2 (en) * 1980-11-29 1984-10-30 フランスベッド株式会社 spring structure
JPS63268910A (en) * 1987-04-24 1988-11-07 Mazda Motor Corp Exhaust purifier for engine

Also Published As

Publication number Publication date
JPS6039264B2 (en) 1985-09-05

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