JPS5663960A - Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituent - Google Patents
Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituentInfo
- Publication number
- JPS5663960A JPS5663960A JP13864479A JP13864479A JPS5663960A JP S5663960 A JPS5663960 A JP S5663960A JP 13864479 A JP13864479 A JP 13864479A JP 13864479 A JP13864479 A JP 13864479A JP S5663960 A JPS5663960 A JP S5663960A
- Authority
- JP
- Japan
- Prior art keywords
- groups
- formula
- prevention
- group
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 239000003130 blood coagulation factor inhibitor Substances 0.000 title 1
- 239000000470 constituent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 206010061216 Infarction Diseases 0.000 abstract 2
- 230000007574 infarction Effects 0.000 abstract 2
- 206010050902 Postoperative thrombosis Diseases 0.000 abstract 1
- RNOIDXRVDBHIGA-UHFFFAOYSA-N [1-(1-hydroxypropan-2-yl)indol-3-yl]-phenylmethanone Chemical compound C12=CC=CC=C2N(C(CO)C)C=C1C(=O)C1=CC=CC=C1 RNOIDXRVDBHIGA-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13864479A JPS5663960A (en) | 1979-10-29 | 1979-10-29 | Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituent |
| EP19800302180 EP0022634B1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
| DE8080302180T DE3062613D1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13864479A JPS5663960A (en) | 1979-10-29 | 1979-10-29 | Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5663960A true JPS5663960A (en) | 1981-05-30 |
| JPS6241500B2 JPS6241500B2 (enrdf_load_stackoverflow) | 1987-09-03 |
Family
ID=15226817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13864479A Granted JPS5663960A (en) | 1979-06-28 | 1979-10-29 | Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5663960A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS579761A (en) * | 1980-06-20 | 1982-01-19 | Teijin Ltd | Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component |
| JPS6072861A (ja) * | 1983-09-28 | 1985-04-24 | Nippon Zoki Pharmaceut Co Ltd | 新規アシルインド−ル誘導体及び該化合物を含有する医薬組成物 |
| JPS6147462A (ja) * | 1984-08-11 | 1986-03-07 | Nippon Zoki Pharmaceut Co Ltd | 新規アシルインド−ル誘導体及び該化合物を有効成分として含有する血小板凝集抑制剤 |
-
1979
- 1979-10-29 JP JP13864479A patent/JPS5663960A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS579761A (en) * | 1980-06-20 | 1982-01-19 | Teijin Ltd | Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component |
| JPS6072861A (ja) * | 1983-09-28 | 1985-04-24 | Nippon Zoki Pharmaceut Co Ltd | 新規アシルインド−ル誘導体及び該化合物を含有する医薬組成物 |
| JPS6147462A (ja) * | 1984-08-11 | 1986-03-07 | Nippon Zoki Pharmaceut Co Ltd | 新規アシルインド−ル誘導体及び該化合物を有効成分として含有する血小板凝集抑制剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6241500B2 (enrdf_load_stackoverflow) | 1987-09-03 |
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