JPS5639068A - Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component - Google Patents

Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component

Info

Publication number
JPS5639068A
JPS5639068A JP11275579A JP11275579A JPS5639068A JP S5639068 A JPS5639068 A JP S5639068A JP 11275579 A JP11275579 A JP 11275579A JP 11275579 A JP11275579 A JP 11275579A JP S5639068 A JPS5639068 A JP S5639068A
Authority
JP
Japan
Prior art keywords
prophylaxis
formula
coagulation inhibitor
blood platelet
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11275579A
Other languages
Japanese (ja)
Inventor
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Takeshi Yu
Seiji Kurozumi
Akira Otsu
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP11275579A priority Critical patent/JPS5639068A/en
Priority to EP19800302180 priority patent/EP0022634B1/en
Priority to DE8080302180T priority patent/DE3062613D1/en
Publication of JPS5639068A publication Critical patent/JPS5639068A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (R1 is H, lower alkyl; R2, R3 are H, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, trifluoromethyl, hydroxyl or R2 and R3 incorporate to form methylenedioxy-, ethylenedioxy; ϕ is aryl alicyclic group).
EXAMPLE: 3-Benzoyl-1-(1-ethoxy-2-propyl)-2-methylindole.
USE: Blood platelet coagulation inhibitor, prophylaxis of infraction in cardiac blood vessels, prophylaxis and remedy for thrombosis after operation, prophylaxis and remedy for blood vessel thrombosis after surgical operation and atherosclerosis. The dose is 0.01W100mg/kg/day.
PREPARATION: For example, the dehydrogenation of a tetrahydroacylindole deviative of formula II is conducted in the presence of a dehydrogenation catalyst and a dehydrogenation agent, preferably in an inert solvent at 50W300°C for 30minW72hr to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP11275579A 1979-06-28 1979-09-05 Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component Pending JPS5639068A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP11275579A JPS5639068A (en) 1979-09-05 1979-09-05 Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component
EP19800302180 EP0022634B1 (en) 1979-06-28 1980-06-27 Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them
DE8080302180T DE3062613D1 (en) 1979-06-28 1980-06-27 Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11275579A JPS5639068A (en) 1979-09-05 1979-09-05 Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component

Publications (1)

Publication Number Publication Date
JPS5639068A true JPS5639068A (en) 1981-04-14

Family

ID=14594728

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11275579A Pending JPS5639068A (en) 1979-06-28 1979-09-05 Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component

Country Status (1)

Country Link
JP (1) JPS5639068A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579761A (en) * 1980-06-20 1982-01-19 Teijin Ltd Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS567762A (en) * 1979-06-28 1981-01-27 Teijin Ltd Acylated indole derivative, its preparation, and platelet coagulation inhibiting agent containing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS567762A (en) * 1979-06-28 1981-01-27 Teijin Ltd Acylated indole derivative, its preparation, and platelet coagulation inhibiting agent containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579761A (en) * 1980-06-20 1982-01-19 Teijin Ltd Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component
JPS6228132B2 (en) * 1980-06-20 1987-06-18 Teijin Ltd

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