JPS5639068A - Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component - Google Patents
Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective componentInfo
- Publication number
- JPS5639068A JPS5639068A JP11275579A JP11275579A JPS5639068A JP S5639068 A JPS5639068 A JP S5639068A JP 11275579 A JP11275579 A JP 11275579A JP 11275579 A JP11275579 A JP 11275579A JP S5639068 A JPS5639068 A JP S5639068A
- Authority
- JP
- Japan
- Prior art keywords
- prophylaxis
- formula
- coagulation inhibitor
- blood platelet
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:Compounds of formula I (R1 is H, lower alkyl; R2, R3 are H, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, trifluoromethyl, hydroxyl or R2 and R3 incorporate to form methylenedioxy-, ethylenedioxy; ϕ is aryl alicyclic group).
EXAMPLE: 3-Benzoyl-1-(1-ethoxy-2-propyl)-2-methylindole.
USE: Blood platelet coagulation inhibitor, prophylaxis of infraction in cardiac blood vessels, prophylaxis and remedy for thrombosis after operation, prophylaxis and remedy for blood vessel thrombosis after surgical operation and atherosclerosis. The dose is 0.01W100mg/kg/day.
PREPARATION: For example, the dehydrogenation of a tetrahydroacylindole deviative of formula II is conducted in the presence of a dehydrogenation catalyst and a dehydrogenation agent, preferably in an inert solvent at 50W300°C for 30minW72hr to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11275579A JPS5639068A (en) | 1979-09-05 | 1979-09-05 | Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component |
EP19800302180 EP0022634B1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
DE8080302180T DE3062613D1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11275579A JPS5639068A (en) | 1979-09-05 | 1979-09-05 | Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5639068A true JPS5639068A (en) | 1981-04-14 |
Family
ID=14594728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11275579A Pending JPS5639068A (en) | 1979-06-28 | 1979-09-05 | Acylated indole derivative and blood platelet coagulation inhibitor containing the same as effective component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5639068A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS579761A (en) * | 1980-06-20 | 1982-01-19 | Teijin Ltd | Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567762A (en) * | 1979-06-28 | 1981-01-27 | Teijin Ltd | Acylated indole derivative, its preparation, and platelet coagulation inhibiting agent containing the same |
-
1979
- 1979-09-05 JP JP11275579A patent/JPS5639068A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567762A (en) * | 1979-06-28 | 1981-01-27 | Teijin Ltd | Acylated indole derivative, its preparation, and platelet coagulation inhibiting agent containing the same |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS579761A (en) * | 1980-06-20 | 1982-01-19 | Teijin Ltd | Acylated indole derivative, its preparation, and pharmaceutical composition containing said compound as active component |
JPS6228132B2 (en) * | 1980-06-20 | 1987-06-18 | Teijin Ltd |
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