JPS5513222A - Aminoalkoxybibenzyl and its acid addition salt - Google Patents

Aminoalkoxybibenzyl and its acid addition salt

Info

Publication number
JPS5513222A
JPS5513222A JP8583378A JP8583378A JPS5513222A JP S5513222 A JPS5513222 A JP S5513222A JP 8583378 A JP8583378 A JP 8583378A JP 8583378 A JP8583378 A JP 8583378A JP S5513222 A JPS5513222 A JP S5513222A
Authority
JP
Japan
Prior art keywords
formula
compound shown
addition salt
acid addition
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8583378A
Other languages
Japanese (ja)
Other versions
JPS6310683B2 (en
Inventor
Ryoji Kikumoto
Jiichi Fukami
Hiroto Hara
Kunihiro Ninomiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP8583378A priority Critical patent/JPS5513222A/en
Priority to US05/943,621 priority patent/US4220603A/en
Priority to CA311,866A priority patent/CA1105931A/en
Priority to HU78MI636A priority patent/HU178306B/en
Priority to DK441878A priority patent/DK152040C/en
Priority to DD78208291A priority patent/DD139255A5/en
Priority to EP78101092A priority patent/EP0001759B1/en
Priority to SU782668855A priority patent/SU786883A3/en
Priority to FI783049A priority patent/FI69840C/en
Priority to DE7878101092T priority patent/DE2861477D1/en
Priority to NO78783399A priority patent/NO146744C/en
Priority to ES474575A priority patent/ES474575A1/en
Priority to IT28531/78A priority patent/IT1099778B/en
Priority to CS786561A priority patent/CS209918B2/en
Priority to ES480091A priority patent/ES480091A1/en
Priority to CS794084A priority patent/CS209917B2/en
Priority to US06/100,741 priority patent/US4323568A/en
Publication of JPS5513222A publication Critical patent/JPS5513222A/en
Publication of JPS6310683B2 publication Critical patent/JPS6310683B2/ja
Granted legal-status Critical Current

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Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I [m is 2W6 integer; n is 2W7 integer; X is substituent group linked to a heterocylic ring, -COOR1(R1 is H or alkyl) or -CON(R2)(R3)(R2 and R3 are H or alkyl)] or its acid addition salt.
EXAMPLE: 2-{4-(4-carboxypiperidino)butoxy}bibenzyl.
USE: Anticoagulants. Having prevtentive action of blood platelet coagulation and effective for medical treatment and prevention of thromboisis.
PROCESS: A compound shown by the formula II (Y is halogen) is reacted with a compound shown by the formula III in the presence of a base in a lower alcohol solvent at 20W150°C to give a compound shown by the formula IV, which is esterified in the presence of an acid catalyst in R1OH to prepare a compound shown by the formula I (X is -COOR1). The compound shown by the formula IV is mode into an acid halide, which is reacted with an amine shown by the formula HN(R2)(R3) to prepare the desired compound [X is -CON(R2)(R3)].
COPYRIGHT: (C)1980,JPO&Japio
JP8583378A 1977-10-07 1978-07-14 Aminoalkoxybibenzyl and its acid addition salt Granted JPS5513222A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP8583378A JPS5513222A (en) 1978-07-14 1978-07-14 Aminoalkoxybibenzyl and its acid addition salt
US05/943,621 US4220603A (en) 1977-10-07 1978-09-19 Pharmaceutically active (omega-aminoalkoxy)bibenzyls
CA311,866A CA1105931A (en) 1977-10-07 1978-09-22 Pharmaceutically active (omega-aminoalkoxy) bibenzyls
HU78MI636A HU178306B (en) 1977-10-07 1978-10-03 Process for preparing pharmaceutically active /omega-amino-alkoxy/-dibenzyl derivatives and acid addition salts thereof
DK441878A DK152040C (en) 1977-10-07 1978-10-04 ANALOGY PROCEDURE FOR PREPARING BIBENZYL DERIVATIVES OR ACID ADDITION SALTS
DD78208291A DD139255A5 (en) 1977-10-07 1978-10-05 METHOD FOR THE PRODUCTION OF (OMEGA-AMINOALKOXY) -BIBENZYLENE AND ITS SAEUREADDITIONAL SALTS
EP78101092A EP0001759B1 (en) 1977-10-07 1978-10-06 (omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances
SU782668855A SU786883A3 (en) 1977-10-07 1978-10-06 Method of preparing (omega-aminoalkoxy)-bibenzyls or their salts
FI783049A FI69840C (en) 1977-10-07 1978-10-06 FRUIT PROCESSING OF PHARMACEUTICAL ACTIVITIES (OMEGA-AMINOALCOXY) -DIBENYL DERIVATIVES
DE7878101092T DE2861477D1 (en) 1977-10-07 1978-10-06 (omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances
NO78783399A NO146744C (en) 1977-10-07 1978-10-06 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY (OMEGA-AMINOALCOXY) -DIBENZYL DERIVATIVES
ES474575A ES474575A1 (en) 1977-10-07 1978-10-06 (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances.
IT28531/78A IT1099778B (en) 1977-10-07 1978-10-06 (OMEGA-AMMINOLACOSSI) PHARMACEUTICALLY ACTIVE BONDS
CS786561A CS209918B2 (en) 1977-10-07 1978-10-09 Method of preparation of the (omega-aminoalcoxy) bibenzyles
ES480091A ES480091A1 (en) 1977-10-07 1979-04-30 (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances.
CS794084A CS209917B2 (en) 1977-10-07 1979-06-13 Method of preparation of the /omega-aminoalkoxy/bibenzyles
US06/100,741 US4323568A (en) 1977-10-07 1979-12-06 Pharmaceutically active (omega-aminoalkoxy)bibenzyls

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8583378A JPS5513222A (en) 1978-07-14 1978-07-14 Aminoalkoxybibenzyl and its acid addition salt

Publications (2)

Publication Number Publication Date
JPS5513222A true JPS5513222A (en) 1980-01-30
JPS6310683B2 JPS6310683B2 (en) 1988-03-08

Family

ID=13869846

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8583378A Granted JPS5513222A (en) 1977-10-07 1978-07-14 Aminoalkoxybibenzyl and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5513222A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6359740A (en) * 1986-08-29 1988-03-15 株式会社　高見沢サイバネテイツクス Non-interrupted electric source for vehicle

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6359740A (en) * 1986-08-29 1988-03-15 株式会社　高見沢サイバネテイツクス Non-interrupted electric source for vehicle

Also Published As

Publication number Publication date
JPS6310683B2 (en) 1988-03-08

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