JPS5651477A - Polycyclic compound containing nitrogen and its preparation - Google Patents
Polycyclic compound containing nitrogen and its preparationInfo
- Publication number
- JPS5651477A JPS5651477A JP12849879A JP12849879A JPS5651477A JP S5651477 A JPS5651477 A JP S5651477A JP 12849879 A JP12849879 A JP 12849879A JP 12849879 A JP12849879 A JP 12849879A JP S5651477 A JPS5651477 A JP S5651477A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- cerebral
- containing nitrogen
- compound containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A polycyclic compound containing nitrogen of formula I (R1 is lower alkyl), and a salt thereof.
EXAMPLE: 17-Oxoeburnan.
USE: An arteriosclerotic agent and a remedy for cerebral and coronary blood vessel disorder and a synthetic intermediate for cerebral vasodilator, having a vasodilator and an antispasmodic actions and an activating action on cerebral metabolism.
PROCESS: An ester derivative of formula II(R2 is lower alkyl; W is O or NH) is hydrolyzed in the presence of an acid catalyst, decarboxylated or dealkoxycarbonylated with a metal halide in a solvent to give the compound of formula I. The compound of formula II is obtained by reacting a compound of formula III with a compound of formula IV (X is halogen) in the presence of a base, and if necessary hydrolyzing the reaction product in the presence of an acid catalyst.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12849879A JPS5651477A (en) | 1979-10-04 | 1979-10-04 | Polycyclic compound containing nitrogen and its preparation |
AU52864/79A AU532001B2 (en) | 1978-11-20 | 1979-11-15 | Polycyclic indole derivatives |
DE7979104535T DE2966204D1 (en) | 1978-11-20 | 1979-11-16 | Eburnane derivatives, their synthesis and pharmaceutical compositions containing them |
EP79104535A EP0013315B1 (en) | 1978-11-20 | 1979-11-16 | Eburnane derivatives, their synthesis and pharmaceutical compositions containing them |
AT79104535T ATE4666T1 (en) | 1978-11-20 | 1979-11-16 | EBURNAN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
EP81104366A EP0042526B1 (en) | 1978-11-20 | 1979-11-16 | Process for producing apovincaminic acid esters and their salts |
HUSU001041 HU185370B (en) | 1979-01-24 | 1979-11-19 | Process for the production of new 17-substituted-eburnane-derivatives |
CA000340171A CA1136139A (en) | 1978-11-20 | 1979-11-20 | Polycyclic indole derivatives |
ES489140A ES8103085A1 (en) | 1979-10-04 | 1980-03-03 | Polycyclic compound containing nitrogen and its preparation |
US06/259,179 US4382936A (en) | 1978-11-20 | 1981-04-30 | Cerebral vasodilator eburnane derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12849879A JPS5651477A (en) | 1979-10-04 | 1979-10-04 | Polycyclic compound containing nitrogen and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5651477A true JPS5651477A (en) | 1981-05-09 |
JPH0122275B2 JPH0122275B2 (en) | 1989-04-25 |
Family
ID=14986221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12849879A Granted JPS5651477A (en) | 1978-11-20 | 1979-10-04 | Polycyclic compound containing nitrogen and its preparation |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS5651477A (en) |
ES (1) | ES8103085A1 (en) |
-
1979
- 1979-10-04 JP JP12849879A patent/JPS5651477A/en active Granted
-
1980
- 1980-03-03 ES ES489140A patent/ES8103085A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPH0122275B2 (en) | 1989-04-25 |
ES489140A0 (en) | 1981-02-16 |
ES8103085A1 (en) | 1981-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5353642A (en) | Preparation of alpha,alpha-dimethylbenzyl-isocyanate or its nuclear-substituted derivatives | |
JPS54130560A (en) | Sipro compound and its preparation | |
HUT49866A (en) | Composition suitable for hindering deposits developing during polymerization and process for producing the phenothiazine derivative active component | |
JPS5651477A (en) | Polycyclic compound containing nitrogen and its preparation | |
JPS5251331A (en) | Process for preparation of unsaturated compounds | |
JPS5673064A (en) | Isoquinoline derivative | |
JPS5543027A (en) | 2-pyridyl-1-phthalazone derivative | |
JPS55100383A (en) | Preparation of novel nitrogen-containing polycyclic compound | |
JPS5531027A (en) | N-phenetyl acetamide derivative | |
ES421284A1 (en) | Procedure for the preparation of derivatives of pirrocolinacetic acids. (Machine-translation by Google Translate, not legally binding) | |
JPS56164144A (en) | Preparation of novel aryloxyacid derivative | |
JPS54109943A (en) | Preparation of phenylglycine derivative | |
DE3271250D1 (en) | Process for preparing 2,4,6-triisocyanatotoluene | |
JPS5646889A (en) | Gold compound and its preparation | |
JPS56161388A (en) | Novel vincamine derivative | |
JPS56167635A (en) | Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative | |
JPS57181032A (en) | Novel cyclohexene derivative | |
JPS5592363A (en) | New 2-azetidinone derivative | |
JPS5555168A (en) | Novel 4-carboxy-2-phenyl-1-phthalazone derivative | |
JPS5547682A (en) | 7-dithienylmethylene-indolizidine derivative | |
JPS5257127A (en) | Process for hexyne-3-ol-1 | |
JPS57131792A (en) | Novel 2-oxabicyclo(2.2.2)octan-3-one derivative | |
JPS56147757A (en) | Amino acid derivative | |
JPS55100382A (en) | Novel nitrogen-containing polycyclic compound and its preparation | |
JPS5772963A (en) | Alpha-(2-pyridyl)arylacetaldehyde |