JPS5651477A - Polycyclic compound containing nitrogen and its preparation - Google Patents

Polycyclic compound containing nitrogen and its preparation

Info

Publication number
JPS5651477A
JPS5651477A JP12849879A JP12849879A JPS5651477A JP S5651477 A JPS5651477 A JP S5651477A JP 12849879 A JP12849879 A JP 12849879A JP 12849879 A JP12849879 A JP 12849879A JP S5651477 A JPS5651477 A JP S5651477A
Authority
JP
Japan
Prior art keywords
formula
compound
cerebral
containing nitrogen
compound containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12849879A
Other languages
Japanese (ja)
Other versions
JPH0122275B2 (en
Inventor
Keiichi Ono
Hajime Kawakami
Sumimoto Katsube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP12849879A priority Critical patent/JPS5651477A/en
Priority to AU52864/79A priority patent/AU532001B2/en
Priority to DE7979104535T priority patent/DE2966204D1/en
Priority to EP79104535A priority patent/EP0013315B1/en
Priority to AT79104535T priority patent/ATE4666T1/en
Priority to EP81104366A priority patent/EP0042526B1/en
Priority to HUSU001041 priority patent/HU185370B/en
Priority to CA000340171A priority patent/CA1136139A/en
Priority to ES489140A priority patent/ES8103085A1/en
Priority to US06/259,179 priority patent/US4382936A/en
Publication of JPS5651477A publication Critical patent/JPS5651477A/en
Publication of JPH0122275B2 publication Critical patent/JPH0122275B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A polycyclic compound containing nitrogen of formula I (R1 is lower alkyl), and a salt thereof.
EXAMPLE: 17-Oxoeburnan.
USE: An arteriosclerotic agent and a remedy for cerebral and coronary blood vessel disorder and a synthetic intermediate for cerebral vasodilator, having a vasodilator and an antispasmodic actions and an activating action on cerebral metabolism.
PROCESS: An ester derivative of formula II(R2 is lower alkyl; W is O or NH) is hydrolyzed in the presence of an acid catalyst, decarboxylated or dealkoxycarbonylated with a metal halide in a solvent to give the compound of formula I. The compound of formula II is obtained by reacting a compound of formula III with a compound of formula IV (X is halogen) in the presence of a base, and if necessary hydrolyzing the reaction product in the presence of an acid catalyst.
COPYRIGHT: (C)1981,JPO&Japio
JP12849879A 1978-11-20 1979-10-04 Polycyclic compound containing nitrogen and its preparation Granted JPS5651477A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP12849879A JPS5651477A (en) 1979-10-04 1979-10-04 Polycyclic compound containing nitrogen and its preparation
AU52864/79A AU532001B2 (en) 1978-11-20 1979-11-15 Polycyclic indole derivatives
DE7979104535T DE2966204D1 (en) 1978-11-20 1979-11-16 Eburnane derivatives, their synthesis and pharmaceutical compositions containing them
EP79104535A EP0013315B1 (en) 1978-11-20 1979-11-16 Eburnane derivatives, their synthesis and pharmaceutical compositions containing them
AT79104535T ATE4666T1 (en) 1978-11-20 1979-11-16 EBURNAN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP81104366A EP0042526B1 (en) 1978-11-20 1979-11-16 Process for producing apovincaminic acid esters and their salts
HUSU001041 HU185370B (en) 1979-01-24 1979-11-19 Process for the production of new 17-substituted-eburnane-derivatives
CA000340171A CA1136139A (en) 1978-11-20 1979-11-20 Polycyclic indole derivatives
ES489140A ES8103085A1 (en) 1979-10-04 1980-03-03 Polycyclic compound containing nitrogen and its preparation
US06/259,179 US4382936A (en) 1978-11-20 1981-04-30 Cerebral vasodilator eburnane derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12849879A JPS5651477A (en) 1979-10-04 1979-10-04 Polycyclic compound containing nitrogen and its preparation

Publications (2)

Publication Number Publication Date
JPS5651477A true JPS5651477A (en) 1981-05-09
JPH0122275B2 JPH0122275B2 (en) 1989-04-25

Family

ID=14986221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12849879A Granted JPS5651477A (en) 1978-11-20 1979-10-04 Polycyclic compound containing nitrogen and its preparation

Country Status (2)

Country Link
JP (1) JPS5651477A (en)
ES (1) ES8103085A1 (en)

Also Published As

Publication number Publication date
JPH0122275B2 (en) 1989-04-25
ES489140A0 (en) 1981-02-16
ES8103085A1 (en) 1981-02-16

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